Esben Svenningsen
@esbensv.bsky.social
Senior Scientist with Novo Nordisk | Process Optimization and Automation PhD in Chemical Biology from TBP lab @ Aarhus University, Denmark. Covalent modifiers, chemoproteomics, morphological profiling / cell painting ORCID: 0000-0001-5118-6499
I am excited to share that the latest project from the @tbpoulsen.bsky.social group, detailing the syntheses and biological evaluation of the four natural products cyclohelminthol I-IV is now available in Chemical Science! doi.org/10.1039/D4SC... A short "Bluetorial" below #ChemSky #ChemBio 1/7
Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
nature.com
A Christmas present to all of the lasso peptide connoisseurs out there. The next chapter in our work is on triculamin is ready on bioRxiv. Great work by two incredibly talented graduate students @amerrild.bsky.social and @tizianasvenningsen.bsky.social. www.biorxiv.org/content/10.1...
Convergent Evolution of the Antimycobacterial Lasso Peptide Triculamin
Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene c...
biorxiv.org
MiBIG 4.0 is online! #secmet #BGC #mibig #microsky academic.oup.com/nar/advance-...
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Abstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag
academic.oup.com
In a new preprint @chemrxiv.bsky.social, work from @bgless.bsky.social and Sabrina Schmied investigate the mechanism of a rearrangement that can lead to peptide/protein backbone cleavage. Thanks to #LEOFondet for funding the project that led to this discovery. chemrxiv.org/engage/chemr...
Peptide Backbone Cleavage and trans-Amidation via Thioester-to-Imide Acyl Transfer
Cysteine thioesters are involved in a myriad of cen-tral biological transformations because of their unique reactivity. Despite their well-studied proper-ties, we discovered an unexpected trans-amidat...
chemrxiv.org
Job alert: fully funded postdoc position in chemical biology in beautiful Geneva! Do you have a PhD in Chemical Biology or related field with organic synthetic experience? Apply now! Details on how to apply can be found here: www.hoogendoornlab.org/joinus #chemsky #ChemBio
Join us! | Hoogendoorn Lab
Openings for PhD students and postdocs will be advertized here
hoogendoornlab.org
Little Reminder: tomorrow 2pm. We are excited 😉
NFDI4Chem@nfdi4chem.de · 2y agoNext STAMMTISCH will be very exciting. Our 3 guests give an "Introduction to the #open #laboratory #communication standard #SiLA and the scientific data standard #AnIML - with a practical demonstration of its #FAIR #data capabilities" 29.11.2024, 14 - 15 CET bit.ly/486Rgzt #chemsky #chemistry
Opportunity in chemical biology & #proteomics at Pfizer (Groton CT USA) ref: 4924293 | closing: 06-Dec-2024 #ChemBiol #biochem #chemsky 🧪 pfizer.wd1.myworkdayjobs.com/PfizerCareer...
Senior Scientist, Chemical Biology and Proteomics
Would you like to discover the medicines of the future? At Pfizer we deliver Breakthroughs That Change Patients Lives. In the Chemical Biology and Proteomics group, we play a vital role in this missio...
pfizer.wd1.myworkdayjobs.com
I want to write a paper titled “the sky is blue, the ocean is deep and trees are green”
Madhu Pai, MD, PhD@madhupai.bsky.social · 2y ago"Non-White scientists appear on fewer editorial boards, spend more time under review, and receive fewer citations" www.pnas.org/doi/abs/10.1...
Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab.bsky.social in Fragpipe in this exciting system. chemrxiv.org/engage/chemr...
Profiling the proteome-wide selectivity of diverse electrophiles
Targeted covalent inhibitors are powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine residues. The development of cysteine-directed covalen...
chemrxiv.org
In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes! Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549 Skeeturial (??) below ⬇️ #ChemSky #ChemBio
