estella newcombe

@estellaan.bsky.social

existing somewhere between neuroscience and biochemistry australian in copenhagen

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered??? www.nature.com/articles/s41...

Stereochemistry in the disorder–order continuum of protein interactions - Nature

Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.

nature.com

i research neurodegenerative proteins (& other idps!) & how their interactions lead to pathology. have bounced between huntington's, alzheimer's & parkinson's, & from structural biology to mouse models & human tissues, so v much a jack-of-all-trades when it comes to neurodegenerative diseases