Eric Van Nostrand Lab @ BCM
@evannostrandlab.bsky.social
Eric Van Nostrand Lab Therapeutic Innovation Center & the BMP Department, Baylor College of Medicine Uncovering how RNA binding proteins control RNA processing
Happy to have helped with this cool work from the Ogilvie lab exploring the role of RBFOX2 in driving altered splicing networks in medulloblastoma! www.biorxiv.org/content/10.6...
RBFOX2 restrains oncogenic cell plasticity in Group 3 medulloblastoma
Cancer cell plasticity underlies tumor progression, metastasis and therapeutic resistance, yet how RNA-binding proteins regulate malignant state transitions remains poorly defined. Here, we identify t...
biorxiv.org
Happy to see Tiantai's cool work on variant U1s & snRNA quality control published in Genes & Development - glad we could help out! pubmed.ncbi.nlm.nih.gov/42562572/
Multiple quality control checkpoints safeguard small nuclear RNA biogenesis and prevent assembly of aberrant spliceosomes - PubMed
Defective small nuclear (sn)RNAs are produced from hundreds of human snRNA pseudogenes and mutant snRNA genes associated with human developmental disorders. Machineries that prevent defective snRNAs f...
pubmed.ncbi.nlm.nih.gov
Advances in CLIP-derived methods have enabled high-resolution mapping of individual RNA binding protein-RNA interactions as well as RNA binding protein-associated RNA–RNA interactions #RNA #CLIP @evannostrandlab.bsky.social bit.ly/4bYjAsg
Happy to share Joey (Zhuoyi)'s review on technologies to map RBP:RNA and (especially) RBP-associated RNA:RNA interactions is now up at RNA! pubmed.ncbi.nlm.nih.gov/41535089
Progress and challenges in profiling protein-RNA and protein-associated RNA-RNA interactions - PubMed
RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-R …
pubmed.ncbi.nlm.nih.gov
Some cool work with the www.daughertylab.org at UCSD is up! Started by looking at how IFIT2/3 inhibit VSV infection, wound up uncovering a new mechanism for translation inhibition of mRNAs with short 5'UTRs pubmed.ncbi.nlm.nih.gov/41093992
Daugherty Lab @ UCSD
daughertylab.org
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
biorxiv.org
Excited to share some new work from our group - www.biorxiv.org/content/10.1... A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
biorxiv.org
If you’re interested in the interplay between regulation (or mis-regulation) of RNA processing and cancer, please check out the 2025 FASEB RNA Processing in Cancer meeting Oct 5-9 2025 in Sacramento CA! events.faseb.org/event/RNA-Pr...
RNA Processing in Cancer: From Bench to Bedside
events.faseb.org
From our lab, Joey will be presenting her snoRNA work in Concurrent session 5 (5/28 afternoon), and Maureen & Jen-Yun have posters on Wed evening Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!
Looking forward to seeing everyone at the @rnasociety.bsky.social meeting!
Happy to say our paper with the Whipple lab on snoRNA target profiling with chimeric eCLIP is now out! Great work by co-first authors Joey & Min with the help of a bunch of other folks! genomebiology.biomedcentral.com/articles/10....
Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP - Genome Biology
Background Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and...
genomebiology.biomedcentral.com
(re-post) Happy to share that our preprint on using chimeric eCLIP to map snoRNA interactions (and find new non-canonical snoRNA:RBP subnetworks) is now up! A fun co-collaboration with the great @LabWhipple lab, and great work by Joey, Min, and others! www.biorxiv.org/content/10.1...
Mapping snoRNA-target RNA interactions in an RNA binding protein-dependent manner with chimeric eCLIP
Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and spliceosom...
biorxiv.org