Kurianlab
@kurianlab.bsky.social
RNA biology lab studying cell fate and cell identity in the context of embryonic development and disease @Goethe University #ribosome #translational_control #RBP #splicing #RNA_localizatilzon https://kurianlab.com/ Alum:@salkinstitute @yeo lab, UCSD
Congrats Danny!
Danny IncaRNAto@incarnatolab.bsky.social · 3d agoThrilled to share the latest review I had the incredible pleasure to write together with @amustoe.bsky.social, out today in #COSB, about probing #RNA structural ensembles, non-equilibrium intermediates and isoforms. Check it out: www.sciencedirect.com/science/arti...
New preprint alert!!! Super proud to finally share an authentic 'tour-de-force' from the amazing PhD students Shivani Gunnan @shivanigunnan.bsky.social, Max Kotz and Lucas Ribas, in collaboration with @friedrich-group.bsky.social 👇a small thread www.biorxiv.org/content/10.6...
Developmental growth rates adapt to enable self-correction of organ morphology after injury.
Proportional organ growth requires tissue-level control of cell behavior. Yet the cues that adapt growth rates, especially after organ injury, remain unclear. Here, we uncover that developing organs a...
biorxiv.org
Our new study shows a CHD-family remodeler can nucleate and spread H3K9 methylation de novo, inverting the canonical hierarchy between writers and remodelers. www.biorxiv.org/content/10.6...
Nucleosome remodeling by a CHD enzyme promotes H3K9 methylation establishment and spreading via remodeler-writer feedback
In Schizosaccharomyces pombe , the conserved CHD remodeler Mit1 function within the SHREC remodeler-deacetylase complex (a homolog of the metazoan Mi-2/NuRD complex), which is essential for H3K9 methy...
biorxiv.org
Please share! What companies have folks successfully worked with to generate custom antibodies? Rough cost? We've been burned once before and want to try a different company this time around.
“AlphaFold 3's representational coherence is deeply tied to evolutionary scaffolding, suggesting it functions similarly to an advanced fold-recognition system and highlighting that protein structure prediction from sequence alone is not yet fully solved.”
biorxiv.org
arXiv has spun out as an independent non-profit like openRxiv. Today they announce their new CEO and founding Board blog.arxiv.org/2026/07/30/a...
arXiv welcomes inaugural CEO and founding Board of Directors
arXiv welcomes inaugural CEO and founding Board of Directors
blog.arxiv.org
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
cell.com
www.nature.com/articles/s41... how cool!
Intestinal stem cells count self-renewal divisions to switch multipotency - Nature
In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...
nature.com
Next summer's Epigenetics GRC (I'm co-chairing with Deborah Bouch'is) is shaping up nicely with an all-star lineup of speakers working on a broad range of organisms and systems and everything from molecular mechanisms to new phenomena. Apply and put it on your calendar! www.grc.org/epigenetics-...
2027 Epigenetics Conference GRC
The 2027 Gordon Research Conference on Epigenetics will be held in Holderness, New Hampshire. Apply today to reserve your spot.
grc.org
A new article from Jeff Coller's lab. www.cell.com/molecular-ce...
Nascent chain folding status modulates ribosome dynamics and mRNA stability through the ribosome-associated chaperone Zuo1
Chang et al. show that co-translational protein misfolding feeds back to ribosomes, slowing translation elongation and triggering mRNA decay. The ribosome-associated chaperone Zuo1 mediates this respo...
cell.com
www.science.org/doi/10.1126/... Check this beauty from @benoitbruneau.bsky.social and colleagues
Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor
Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...
science.org
Beautiful work at the intersection of 3d genome biology, splicing and senescence from @akispapantonis.bsky.social Congrats buddy.
Akis (Argyris) Papantonis @akispapantonis.bsky.social · 2w agoOur latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells. www.nature.com/articles/s43...
Sometimes the dark alleys are in fact dark alleys that we shouldn't have gone down. But sometimes the dark alleys are really the path to enlightenment. And we don't really know, ahead of time, which one is going to go, unfortunately. –@harmitmalik.bsky.social on the Night Science Podcast, episode 6
In their Review, Alexandra Edwards and Elizabeth Finn discuss how genome organisation underlies evolution and development. journals.biologists.com/jcs/article/...
Wrote a short piece on Transposable Elements as catalysts of evolutionary innovation for a forthcoming special issue of @naturerevgenet.bsky.social on, duh, Evolutionary Innovation! www.nature.com/articles/s41...
Transposable elements as catalysts of evolutionary innovation - Nature Reviews Genetics
In this Comment, Cedric Feschotte highlights evidence from diverse lineages showing that transposable elements are key drivers of evolutionary innovation, repeatedly introducing regulatory and coding ...
nature.com
🚨 Want to start your lab in Marseille on a broad neuronal/brain development theme? There's an exciting tenure track opportunity at @inp-marseille.bsky.social and others Marseille institutes! Check more details here: neuro-marseille.org/en/blog/juni... or contact me if you have any question
2 super cool papers on pre-mRNA splicing: www.cell.com/cell/abstrac... www.biorxiv.org/content/10.6...
Spliceosome loss in the red tide ciliate Mesodinium rubrum presents a symbiotic cul-de-sac
Mesodinium rubrum , a marine microbial eukaryote associated with some of the largest red tides on Earth, has the remarkable ability to commandeer the plastids, mitochondria and nuclei from the alga Te...
biorxiv.org
Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/
An encyclopedia of human enhancer–gene regulatory interactions - Nature
An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...
nature.com
A DNA break-5mC cycle activates transposable elements in Arabidopsis | PNAS www.pnas.org/doi/abs/10.1...
A DNA break-5mC cycle activates transposable elements in Arabidopsis | PNAS
Plant genomic and epigenomic integrity are perpetually threatened by exogenous and endogenous DNA damage. However, the interplay between DNA damage...
pnas.org
Manuscripts with women as corresponding authors are less frequently sent out for review at Science. The ones reviewed receive less favorable reviews by both male and female reviewers.
Javi Ibarrondo@jibarrondo.bsky.social · 3w agoEditorial and peer review dynamics at elite general science journals | Science Advances www.science.org/doi/10.1126/... 🧪
Nature News covered our preprint on LLM analysis of Preprint-to-Publication transition 😆👇 Think preprints are unreliable? Analysis of 70,000 studies might change your mind www.nature.com/articles/d41... Kudos to @rrust.bsky.social for leading this project👍 www.biorxiv.org/content/10.6...
How cool!!
Nicholas Bellono@nbellono.bsky.social · 4w agoHow did octopuses evolve novel traits? Rishav Mitra, Richard Han, Trey Scott, et al serendipitously discover a unique ribosome adaptation that increases the accuracy of protein synthesis and evolved alongside their elaborate nervous systems vs deep sea relatives. www.biorxiv.org/content/10.6...
In print today @science.org Laser phase plate improves structure determination of small proteins by cryo-EM | Science www.science.org/doi/10.1126/...
Laser phase plate improves structure determination of small proteins by cryo-EM
Phase plates can, in principle, overcome the poor image contrast in cryo–electron microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. However, previous de...
science.org
📣 Applications are open for the next NAR Early Career Investigator (ECI) Advisory Board cohort! Work with Executive Editors, help shape journal strategy, and gain insight into peer review during a 2-year term. Apply by 1 Nov 2026: lnkd.in/g233ZCAf #ECR #NAR #AcademicPublishing #MolecularBiology
A bacterial reverse transcriptase: Protein-templated DNA synthesis fuels antiviral immunity
A bacterial reverse transcriptase: Protein-templated DNA synthesis fuels antiviral immunity
In a recent issue of Science, Deng et al. report a bacterial defense-associated reverse transcriptase, DRT3, that synthesizes poly(GT/AC) repeat double-stranded DNA by coupling RNA-templated and protein-templated mechanisms, expanding the functional repertoire of reverse transcriptases in antiviral immunity.
dlvr.it
www.tsinghua.edu.cn/en/info/1244... 2025 Nobel laureate in Chemistry Omar M. Yaghi officially vacated his position at UC Berkeley to join Tsinghua University on a full-time basis in Beijing. He is establishing and leading a new university-level AI Chemistry and Materials Research Institute.
Nobel Laureate in Chemistry Omar M. Yaghi joins Tsinghua University full-time-Tsinghua University
On the morning of July 3, Tsinghua University held the Appointment Ceremony for Professor Omar M. Yaghi as Chair Professor of Tsinghua University at the Main Building.
tsinghua.edu.cn
The #EZM2026 (European Zebrafish Society @ezsociety.bsky.social meeting) is in full swing! More than 500 (not only zebra-)fish researchers from all over the world gather here in Vienna for the next 5 days to discuss science, exchange ideas and make new connections. #Fish #Zebrafish #Friends
Discoveries can hide in plain sight. #HHMIInvestigator Steven Henikoff's lab found a surprise when revisiting their old data: a region of ribosomal DNA producing microRNAs that can be associated with cancer, revealing a new role for part of the genome overlooked for decades: bit.ly/3RQwTmy.
