Happy to share our recent preprint on experimental evolution for bleomycin resistance in yeast, in which we highlight both background-dependent mutational footprints and a shared molecular mechanism underlying their adaptation. www.biorxiv.org/content/10.6... #yeast #LTEE

Genetic background diversifies mutational paths but converges on membrane depolarization for bleomycin resistance in yeast

Drug resistance evolution is shaped by both selective agent and genetic background in which resistant mutations arise, but most experimental evolution studies rely on a single genetic background. Here...

biorxiv.org

Glad to see this joint work on nasopharyngeal microbiota culturomics published in #ScienceTranslationalMedicine, featured as a cover story! By building this local bacterial catalog, we characterized a Fusobacterium-Prevotella mutualism in nasopharyngeal tumors. www.science.org/doi/10.1126/...

Culturomics reveals Fusobacterium-Prevotella mutualism as a hallmark of nasopharyngeal tumor microbiota

A culturable nasopharyngeal bacterial catalog was built, which reveals mutualism between Fusobacterium and Prevotella that affects tumor therapy response.

science.org

Glad to see this joint work finally out in Nature Cancer @natureportfolio.nature.com ! A truly tour-de-force multiomics quest into nasopharyngeal carcinoma subtyping and its clinical implications! www.nature.com/articles/s43...

Multi-omic characterization of nasopharyngeal carcinoma delineates the subtype-specific landscape of response to induction chemotherapy - Nature Cancer

Li et al. conduct a multi-omics analysis of nasopharyngeal carcinoma and identify three molecular subtypes with distinct immune profiles and responses to induction chemotherapy.

nature.com

Excited to share our PNAS paper on the genome evolution of an early-diverging #amphioxus, Asymmetron lucayanum! There is a long and twisty story behind this work, which also explains the username choice of the lab PI @iamphioxus.bsky.social . 😀 @pnas.org www.pnas.org/doi/10.1073/...

Insights into cephalochordate genome and gene evolution from the early-diverging amphioxus Asymmetron lucayanum | PNAS

Cephalochordates (amphioxus or lancelet) are considered as living proxies for ancestral chordates due to their key phylogenetic position and slow e...

pnas.org

Honored to serve @genomebiolevol.bsky.social and the greater @official-smbe.bsky.social community! 🫡

Genome Biology and Evolution@genomebiolevol.bsky.social · 6mo ago

GBE proudly welcomes seven new Associate Editors to its Editorial Board! These researchers bring vast experience in genomic sciences and evolutionary biology, and will provide a great service to the SMBE community. We will be presenting these colleagues throughout the coming days. #societyjournal

Honored to serve on the Yeast Genetics Meeting Program Committee of Evolution & Population Genetics. Welcome for meeting registration and abstract submission, especially on our Evolution & Population Genetics program! genetics-gsa.org/yeast-2026/ @genetics-gsa.bsky.social #Yeast26

Homepage - Yeast Genetics Meeting 2026

Visit our website to learn more.

genetics-gsa.org

First #SMBE meeting for our lab！Definitely a memorable experience. Already looking forward to the next one! @official-smbe.bsky.social #SMBE2025

📣 Glad to share our genome paper on an early-diverged cephalochordate (amphioxus) species, Asymmetron lucayanum! By decoding & analyzing this genome in a comparative genomics framework, we know better now regarding the genome and gene evolution in cephalochordates. www.biorxiv.org/content/10.1...

The genome of the early diverged amphioxus, Asymmetron lucayanum, illuminates the evolution of genome architecture and gene repertoires in cephalochordates

Cephalochordates (amphioxus or lancelet) are considered as living proxies for ancestral chordates due to their key phylogenetic position and slow evolutionary rate. The genomes of living amphioxus thu...

biorxiv.org

📣Our #SMBE 2025 Symposium (No. 3) on Experimental Evolution will be held today (7.22, Tuesday) at 10:30 in Room 4, Building No. 8. An associated poster session will be held at 14:00 (poster number: S3-P01~P16). Welcome to join! let's study evolution in action! 🥳 🎉 @official-smbe.bsky.social

Welcome to attend our SMBE2025 Symposium on Experimental Evolution. Co-organized by Dao-Qiong Zheng, @‪jingli-0512.bsky.social‬ and myself.

Society for Molecular Biology and Evolution@official-smbe.bsky.social · last yr.

#SMBE2025 Symposium 3: Experimental evolution: studying evolution in action 🔗 smbe2025.scimeeting.cn/en/web/program/25070

📢 3 Postdoc positions available in @evomicslab.bsky.social targeting on genome instability evolution of both yeast and human genomes. Both computational genomics and experimental genomics backgrounds are welcome! 🧬🧑‍💻🧪 For more information, see evomicslab.org or send me a message!

Glad to see the copy-edited version of our VRPG paper formally published in the latest issue of @genomeresearch.bsky.social ! We developed VRPG as a novel visualization framework for intuitively exploring pangenome graphs in a linear-reference-projected context. genome.cshlp.org/content/35/2...

Interactive visualization and interpretation of pangenome graphs by linear reference–based coordinate projection and annotation integration

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

genome.cshlp.org

📢📢📢 The FINAL COUNT DOWN for the extended abstract submission deadline of #SMBE2025! Please submit your abstract by 23:59 (GMT +8) of February 15, 2025 [Saturday]! And shout out again for our symposium on Experimental Evolution ! 🎉🎉🎉 @OfficialSMBE #LTEE #ExperimentalEvolution

Society for Molecular Biology and Evolution@official-smbe.bsky.social · 2y ago

📢📢📢 #SMBE2025 Abstract Submission EXTENDED to Saturday, February 15, 2025 We also invite you to register at www.smbe2025.org @SMBEmeetings

📢🧬Proud to announce our 1st work on pangenome graphs is early online @genomeresearch.bsky.social ! Here we developed an interpretative visualization framework for pangenome graphs named VRPG, which seamlessly bridges the graph and linear genomics world. genome.cshlp.org/content/earl...

📢 2nd-round abstract submission call for the 2025 @OfficialSMBE annual meeting in #Beijing . Where: smbe2025.scimeeting.cn/en/web/index... When: now - 2025/01/30. Welcome for all abstract submissions, especially for our Experimental Evolution Symposium !!!

📣 ⚠️👀Attn: The abstract submission for the #SMBE2025 meeting in Beijing @official-smbe.bsky.social is open now! Submission site: smbe2025.scimeeting.cn/en/web/index... Submission Deadline: 2025.01.30 Welcome for all abstract submissions, especially for our Experimental Evolution Symposium !!!

Welcome to join our dedicated symposium on Experimental Evolution for the @MolBioEvol 2025 Beijing Meeting! See you in Beijing!

Jia-Xing Yue (岳家兴)@iamphioxus.bsky.social · 2y ago

Glad to announce that our (with Dao-Qiong Zheng & Jing Li) proposed symposium on #ExperimentalEvolution has been selected for the @official-smbe.bsky.social 2025 conference in #Beijing! @petrovadmitri.bsky.social will be our invited speaker! Please save the date and consider joining our symposium!

The copy-edited version of our NanoTrans paper has been recently published @JGenetGenomics ! Here we developed an all-in-one pipeline for comprehensive data analysis for @nanoporetech.com direct-RNA sequencing (#DRS). www.sciencedirect.com/science/arti...

NanoTrans: an integrated computational framework for comprehensive transcriptome analysis with nanopore direct RNA sequencing

Nanopore direct RNA sequencing (DRS) provides the direct access to native RNA strands with full-length information, shedding light on rich qualitative…

sciencedirect.com

Excited to introduce the ScRAPdb work that we recently published at Nucleic Acids Research, in which we assembled a #pangenome x #multi-omics database for #yeast. This is one step forward for a pan-multi-omics understanding of genome & trait evolution. Read more > academic.oup.com/nar/advance-...

ScRAPdb: an integrated pan-omics database for the Saccharomyces cerevisiae reference assembly panel

Abstract. As a unicellular eukaryote, the budding yeast Saccharomyces cerevisiae strikes a unique balance between biological complexity and experimental tr

academic.oup.com