Humans live many more years than mice, but our brain networks are aging much faster. Brain network decline follows a common trajectory across mouse and human adulthood, with features of network organization linked to more rapid decline. www.pnas.org/doi/10.1073/...

🎉Huge congratulations to McEwen fellow @ewinternelson.bsky.social and Dr. Gagan Wig of UT Dallas on their recent publication in PNAS on large-scale brain network decline across aging mice and humans and its translational relevance. Read the paper here: shorturl.at/gjau5

Correspondence of large-scale functional brain network decline across aging mice and humans | PNAS

Human aging is marked by progressive reorganization of large-scale functional brain networks; these brain network changes have been linked to cogni...

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The first part of my PhD research is out now in PNAS! See the thread below and stay tuned for my dissertation work, which builds on this cross-species model of brain network aging

Gagan Wig@gaganwig.bsky.social · 4mo ago

Aging reorganizes human large-scale brain networks, with consequences for cognition & dementia risk. We’ve now mapped brain network changes over a wide range of the mouse lifespan. The changes mirror key features of human aging, but not entirely New @pnas.org paper🧵 www.pnas.org/doi/10.1073/...