Fernando Rossine
@fernpizza.bsky.social
Professionally playing with plasmids! Postdoc-ing until someone here scouts me for a PI position ;) Princeton EEB -> Harvard Medical School -> Soon ETH Zürich!
1/9 New preprint from the Sternberg Lab in collaboration with the Nishimasu Lab! We uncover how the DRT3 antiphage immune system pairs two reverse transcriptases, one RNA-templated and one protein-templated, to build a double-stranded DNA effector. doi.org/10.64898/202...
Dr. Indra Gonzalez Ojeda gave a great thesis defense this morning, including some wisdom for starting PhD students, or frankly, anyone.
This Plasmid Project was directly inspired by the results on multilevel selection that Dan introduced me to! In this thread he explains some fundamental theoretical results that were so influential to me as a Scientist. Looking forward to more Math-driven experiments!!! Thanks Dan!
Daniel Cooney@danielcooney1.bsky.social · 10mo agoI'm really excited to see this paper by @fernpizza.bsky.social, @baym.lol, et al. This is a great model system for studying multilevel selection, and the experimental work builds nicely on cross-scale theoretical modeling approaches that I've enjoyed learning about over the past few years. 🧵
This is it!!! This is the work I never want to stop hearing about. Kepler’s creativity and curiosity really shine through in this paper. Give it a read and enjoy 😎
Everyone's least favorite lab mate@kepatitis-c.bsky.social · 10mo agoWhat is the best strategy to win any contest? Eliminate your opponents of course. Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight. www.biorxiv.org/content/10.1...
This has been an intense, crazy week. My plasmid competition paper is finally out and we have a new preprint on Bioarxiv! Plus I'm leaving the US after 10 years here. See you soon America! Hello Zurich!!!
Michael Baym@baym.lol · 10mo agoHot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...
When different kinds of mobile genetic elements get together, they become even more powerful catalysts for microbial evolution! In this work we discovered a mechanism by which Insertion Sequences drive their spread across Plasmids, which helps explain this evolutionary potential!
Everyone's least favorite lab mate@kepatitis-c.bsky.social · 10mo agoWhat is the best strategy to win any contest? Eliminate your opponents of course. Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight. www.biorxiv.org/content/10.1...
I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! (1/n) www.biorxiv.org/content/earl...
Intracellular competition shapes plasmid population dynamics
Conflicts between levels of biological organization are central to evolution, from populations of multicellular organisms to selfish genetic elements in microbes. Plasmids are extrachromosomal, self-r...
biorxiv.org
