Had a great time at the Microbiology Society Conference in Belfast! Really enjoyed the talks, posters, and discussions — and Belfast was amazing too (and sunny!) 😊 Happy to have given a talk on astrovirus RNA structures! @microbiologysociety.org #Microbio26
@foxenia.bsky.social
So incredibly proud of David! Seeing all the hard work pay off is the best. Huge congrats on a brilliant viva!
Congratulations to David Noyvert on acing his PhD viva! Many thanks to the excellent examiners @markohyvonen.bsky.social and Lidia Vasilieva!
Our delicious uuORF cake baked by @valerialulla.bsky.social 🎂
And a cake to celebrate!
New lab paper in PLOS Pathogens! We show how enteroviruses use upstream AUGs to modulate protein expression. I was glad to join the project in its final stages and contribute to the concluding efforts of this great collaboration. #Enterovirus #RNA #Cambridge
🚨 New paper from the lab! 🚀 We explore flexibility and modulation of IRES-dependent translation in enterovirus genomes through upstream ORFs. Many thanks to all co-authors from the @campathology.bsky.social, CIMR and Cambridge Stem Cell Institute! dx.plos.org/10.1371/jour...
Favorite volunteering gig: Big Biology Day in October! 💚 Huge thanks to our next-generation assistants — the teens who made it all run so smoothly! And to @valerialulla.bsky.social, who inspires (and leads!) our station every year 🙌
Our lab is recruiting a PhD student to explore how RNA viruses hijack ribosomes and reprogram host translation. A great opportunity for anyone passionate about RNA biology and virology!
📢 We are hiring! We have a fully funded 4-year PhD studentship to study how RNA viruses steal ribosomes and reprogram host translation, thanks to funding from @campathology.bsky.social and @wellcometrust.bsky.social! Come join us! Full details: www.path.cam.ac.uk/graduate/ful...
These findings are similar to recent work on the EMCV Type 2 IRES — see e.g. www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1... — and suggest that common structural motifs and mechanisms may exist within highly divergent picornavirus IRES sequences
The mechanism of ribosomal recruitment during translation initiation on Type 2 IRESs
The encephalomyocarditis virus (EMCV) IRES and other Type 2 IRESs comprise domains H-L and specifically interact with eIF4G/eIF4A through their essential JK domain. However, the JK domain is not suffi...
biorxiv.org
The preprint from this great collaboration just went live!
Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem: www.biorxiv.org/content/10.1...
Wonderful to be part of this collaboration — great teams and great science!
This was a fantastic collaboration with the groups of @valerialulla.bsky.social @campathology.bsky.social and Trevor Sweeney @pirbrightinst.bsky.social. Thanks also to superb colleagues and facilities @biologyatyork.bsky.social, YSBL, @ybri-uoy.bsky.social and @diamondlightsource.bsky.social
Celebrating with the amazing @campathology.bsky.social team at #Microbio25! Fantastic talks, posters, and great company! 👏 @microbiologysociety.org
Celebratory dinner for the @campathology.bsky.social crew at #microbio25 to celebrate fabulous talks and poster presentations!
A nighttime shot of a grand hall filled with posters at #Microbio25. Thanks to everyone who came to the discussion about functional RNA elements in viral genomes after finding my poster among this abundance. @microbiologysociety.org
Excited to attend the annual conference in Liverpool! Great talks, many old and new faces, lovely city! #Microbio25 @microbiologysociety.org
#Microbio25 has officially begun! We look forward to welcoming you all to our four-day conference, packed with the latest microbiology research, professional development sessions and so much more. View the full programme: