📢 New publication alert 📢 🧪Studying enzyme conformational dynamics always hides new surprises, especially when you discover that beneficial mutations destabilize the enzyme! Read more here ---> doi.org/10.1002/cbic... Thread 🧵 1/5

I am more than excited and grateful for such an opportunity at #Biotrans2025! The session was out of this world. Big thanks to the organizing committee. The Q&A and after session was fantastic. Keep tuned for upcoming news! #MSCA

Roelfes Group@roelfesgroup.bsky.social · last yr.

Our postdoc @francdefel.bsky.social just gave a fantastic talk on gold-based artificial metalloenzymes for asymmetric catalysis. #Biotrans2025 @stratinghinst.bsky.social @rug.nl

Great experience at the Green Chemistry & Engineering Conference! Amazing time around a neat program. Extremely grateful for giving me the chance to share my work in an environment that pushes towards sustainable research #GreenChemistry #MSCA @acsgci.bsky.social @roelfesgroup.bsky.social

📢📢📢 PhD Opportunity! Join our research group at RUG! We're seeking a motivated PhD student for a project on biocatalytic cascade processes combining natural and designer enzymes, supported by machine learning. Click below to learn more — and feel free to share! sites.google.com/rug.nl/roelf...

Roelfes group - Open Positions

PhD position on Hybrid biocatalytic cascades aided by Machine learning (1.0 FTE)

sites.google.com

Check out this week’s #ChemSciPicks from Gerard Roelfes (@roelfesgroup.bsky.social, @stratinghinst.bsky.social) et al.! ‘Genetically Encoded 3-Aminotyrosine as Catalytic Residue in a Designer Friedel-Crafts Alkylase’ Read it here for free: doi.org/10.1039/D5SC... #ChemSky 🧪

Very happy to share our latest work on artificial enzyme catalysis in @chemicalscience.rsc.org! Very grateful for being a #ChemSciPicks. 📃 doi.org/10.1039/D5SC... All my thanks to @brouwerb.bsky.social and @roelfesgroup.bsky.social #OpenScience #MSCA

Bart Brouwer@brouwerb.bsky.social · last yr.

Very proud to share that one of my main PhD projects has been published in @chemicalscience.rsc.org, and that it has been selected as a #ChemSciPicks of the week paper! Keep reading below for more details, or check out the full paper for free online: doi.org/10.1039/D5SC... Thread ⬇️

Had an amazing week at #ACSSpring2025! It was an intense but incredibly rewarding experience with top speakers and insightful discussions. I'm grateful for the opportunity to present my research in the biocatalysis session - awesome interaction! #MSCA @roelfesgroup.bsky.social

Happy to present my current work at N3C! Amazing conference with an excellent program💯💯

Roelfes Group@roelfesgroup.bsky.social · last yr.

Our group members Tanja and Franco @francdefel.bsky.social presented their exciting research at NCCC this week. Franco talked about his work on asymmetric catalysis in gold-based artificial metalloenzymes.

Grateful to be part of this awesome project lead by @brouwerb.bsky.social. Take a look to our preprint about unlocking iminium ion catalysis when using amino-tyrosine as a genetically encoded amino acid! 🤓 #MSCA @roelfesgroup.bsky.social

Bart Brouwer@brouwerb.bsky.social · last yr.

Check out our latest preprint, in which we demonstrate the first example of using noncanonical 3-aminotyrosine (aY) as a catalytic residue for iminium activation in a designer enzyme! Thread ⬇️

Excellent piece of work. Congrats to the whole team!

Roelfes Group@roelfesgroup.bsky.social · 2y ago

We are thrilled to share our new noble-metal enzyme design approach. We used the in-vivo incorporation of a noble-metal-binding ligand for ArM design to bridge the versatility of noble metals with the catalytic power of enzymes. Thread ⬇️