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FrankeLab

@frankelab.bsky.social

Plant Natural Products Group at Leibniz University Hannover. We study the biosynthetic pathways of complex specialised metabolites from plants. https://www.botanik.uni-hannover.de/en/research/research-groups/biochemistry-of-plant-specialised-metabolites

13 Posts236 Follower131 Folgt
Kai Blin@kblin.bsky.social · 2mo ago

HMMER is an integral part of the software my whole career is built on. Software that researchers at the DOE have run millions of times. Complete, utter bollocks.

Zamin Iqbal@zaminiqbal.bsky.social · 2mo ago

This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work "had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated," www.npr.org/2026/05/21/n...

Jens Boch@mikrobenjaeger.bsky.social · 4mo ago

The Leibniz University Hannover/Germany has an open position for a Professor for Molecular Phytopathology (W2TTW3)! Apply before April 27. Please forward this! Contact me for questions. See you in Hannover! 😃🎓🪴🌾🌱🌽🥬🦠🧪🧫🧬🔬🧑‍🔬👩‍🔬👍 www.uni-hannover.de/en/jobs/8410/ (EN) www.uni-hannover.de/de/jobs/8410/ (DE)

University Professorship in Molecular Phytopathology – Leibniz University Hannover

uni-hannover.de

Lichman Lab@lichmanlab.bsky.social · 11mo ago

Hello! We are currently hiring for two post-doc positions on projects related to plant natural products, enzymes, and developing new systems to make useful small molecules. More details on our website: lichmanlab.weebly.com/post-docs.html

Post-Docs

We are currently recruiting for two post-doc positions in the Lichman lab that require similar skills and experience. We aim to do a joint recruitment process with a single interview. If you apply...

lichmanlab.weebly.com

Nadine Ziemert@nadineziemert.bsky.social · 11mo ago

⏰ Just 7 days left for our Glycopeptide Renaming Challenge! 💡 Share your best name idea and win 500€ 👉 More info and submission here: docs.google.com/forms/d/1ym9... #secmet #NaturalProducts #Antibiotics #NamingChallenge #Glycopeptides @gdwantibiotics.bsky.social @marghesosio.bsky.social

Naming Challenge: Help Redefine the Glycopeptide Family!

We are excited to launch a naming competition inspired by the recent preprint "Phylogenetic distance and structural diversity directing a reclassification of glycopeptide antibiotics" (https://www.bio...

docs.google.com

FrankeLab@frankelab.bsky.social · last yr.

Extremely happy to see our withanolide biosynthesis paper out in @natcomms.nature.com‬ rdcu.be/evHOF Fantastic team effort with the Pucker group @bpucker.bsky.social‬ @puckerlab.bsky.social‬ at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de

Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis

Nature Communications - Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown....

rdcu.be

Plantae.org@plantaeofficial.bsky.social · last yr.

Plant Science Research Weekly -- Elucidation and recreation of the biosynthetic pathway for taxol (Nature) @cmcclune.bsky.social‬ (Summary by Mary Williams @PlantTeaching.bsky.social) buff.ly/miccEK3 #PlantaePSRW

Elucidation and recreation of the biosynthetic pathway for taxol | Plantae

Paclitaxel (sold as Taxol) is taxane diterpene natural product of yew trees (Taxus spp.) and a potent stabilizer of microtubules that is effective in treatment of cancers. However…

buff.ly

FrankeLab@frankelab.bsky.social · last yr.

Fantastic work by the Sattely group on taxol biosynthesis, featuring a highly innovative application of single nuclei sequencing to find elusive biosynthetic genes 👏 www.nature.com/articles/s41...

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature

An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

nature.com

FrankeLab@frankelab.bsky.social · last yr.

Started as a very successful master thesis, now published in JACS. Screening sequence similarity networks turned out to be a great way to discover oxidosqualene cyclases with unusual activity from more than thousand plant transcriptome sequence datasets. pubs.acs.org/doi/10.1021/...

Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants

Triterpenoids and steroids are structurally complex polycyclic natural products with potent biological functions, for example, as hormones. In all eukaryotes, the carbon skeletons of these compounds a...

pubs.acs.org

Andy Truman@andytruman4.bsky.social · 2y ago

We have a fully funded 4-year PhD studenship available that builds on parts of this pre-print: biodtp.norwichresearchpark.ac.uk/projects/dis... 🗓️ Deadline 25 Nov 2024 Please do get in touch if you're interested!

Discovery and Function of Natural Metalloprotease Inhibitors | Doctoral Training Partnership

TRUMAN_J25DTP2

biodtp.norwichresearchpark.ac.uk

Andy Truman@andytruman4.bsky.social · 2y ago

New pre-print from the group 🥳 We use targeted genome mining to show that the plant pathogen Rhodococcus fascians makes the antibiotic lydiamycin. The BGC information then informed the discovery of multiple key features relating to the molecule 1/4 #biosynthesis www.biorxiv.org/cgi/content/...