Andy Truman

@andytruman4.bsky.social

Group Leader at the John Innes Centre. Biosynthesis and discovery of specialised metabolites. Norwich. He/Him. https://www.jic.ac.uk/people/andrew-truman/

People are starving to death, or being gunned down while desperately trying to access food at aid sites — even journalists are in grave danger. This abhorrent situation cannot be allowed to continue www.bbc.co.uk/news/live/cv...

Gaza health ministry says 33 people dead from malnutrition in last 48 hours

New figures from the Hamas-run ministry include 12 children who have died, as the UN says Israel must allow aid into Gaza.

bbc.co.uk

It always pleases me to see how little we know. I can pick a random ~700 AA protein from a bacterial genome and it has no conserved domains and no characterised structural homologues, yet there are >1000 homologues across diverse Gram+ and Gram- bacteria.

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Harmless Scientific Experiments for Boys (the introduction does at least acknowledge that girls can also use the book) including such “harmless” experiments as making gas from coal, and a DIY thermometer involving your own glass blowing and “a very small quantity of mercury” 🤔

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Well the award for most cowardly, boot-lickingest academic society has squarely gone to the American Society of Microbiology, who has taken down features of various non-white scientists. Absolutely pathetic behavior. Those articles are now coming up as “under review”. Truly sickening cowardice here.

Is anyone having issues with NCBI at the moment? Really difficult to reliably retrieve sequence data using Entrez. Unsure if this is an impact of the absurd presidential decisions about the NIH, or just routine maintenance?

Returning to the UK after a great trip to beautiful Gent. Alway a pleasure to hear about the natural products research happening there 😊 Also got to dress up in a gown for the first time in years! Now to the JIC Mol Micro Xmas lunch to “recover” after last night’s Belgian beers 😂

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Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Abstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag

academic.oup.com

We find a lot of proteins - particularly antibiotic biosynthetic enzymes - are produced in soluble form in Streptomyces lividans but not E.coli. It’s a useful platform for the production of otherwise intractable proteins.

ActinoBase@actinobase.bsky.social · 2y ago

pIJ86 sequence and map just added to actinobase.org. Useful for anyone wanting to over produce proteins in Streptomyces species. Plasmid available free from JIC (streptomyces.org.uk)