Aaron Vogan

@fungage-lab.bsky.social

Researches fungal evolution/genetics/genomics. Associate professor at the University of Uppsala, investigating accessory genomes and giant TEs in Fungi.

Come join the Horianopoulos Lab! I am recruiting a graduate student to join my research group focused on the genetic determinants of yeast stress responses. How to apply: Email lhoriano@uoguelph.ca by July 15, 2026 with a CV and cover letter. Subject line: “Horianopoulos lab graduate position”

This project builds on our recent observations that pathogenic yeasts vary substantially in their in vitro susceptibility to external stress and aims to:
Characterize why this variation exists using comparative genomics and transcriptomics.
Identify strategies to sensitize pathogenic yeasts to host-like stress for antifungal therapy development.
Validate targets using genetic knockout or overexpression strategies.

What we’re looking for:
Curious and motivated student with a willingness to learn new things.
Experience in microbiology, molecular biology, genetics, and/or genomics is an asset.
Strong research ethics and the ability to work respectfully as part of a diverse team.

A bit about the Horianopoulos lab - see lab website (QR code) for more:
Interested in what makes yeast vary (macroevolution of yeasts).
Focused on identifying and manipulating the genetic determinants of yeast stress responses.
Located in the Food Science Department at the University of Guelph.
Has a network of local and global collaborators.
How to apply:
Interested applicants should contact Dr. Horianopoulos (lhoriano@uoguelph.ca) by July 15, 2026 with a CV and cover letter. Please put “Horianopoulos lab graduate position” as the subject line. A Fall 2026 or Winter 2027 start is preferred.

4/8 And lurking in those plastic, repeat-rich regions: Starship-like elements - sometimes close to virulence-associated orthologs. Big mobile elements doing their big mobile-element things.

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As promised: We have an open 2-year postdoc position in my lab at HHU Düsseldorf, starting September 2026. Come join us and help pioneering structural biology of fungal GPCRs! More about the lab: altegoerlab.de Apply here: karriere.hhu.de/index.php?ac... Please share with interested candidates!

Postdoc (m/f/d) structural biology of fungal G-Protein coupled receptors

karriere.hhu.de

Altegoerlab@faltegoer.bsky.social · 4mo ago

We just received funding for a 2yr postdoc position on cryoEM of fungal gpcrs. Official call will open soon. Contact me if you‘re interested!

#TEsky Glomhopper-a subfamily of DUF3504-encoding CryptonA elements in Glomeromycota doi.org/10.1186/s131...

Glomhopper—a subfamily of DUF3504-encoding CryptonA elements in Glomeromycota - Mobile DNA

Background Transposable elements drive genomic changes and are mobilized by specific nucleases. Among them are tyrosine recombinases (YRs), which mediate DNA cleavage and rejoining. YR-encoding elements, such as DIRS, Ngaro, Crypton, and Starships, occur in diverse eukaryotes and display characteristic terminal repeat structures that enable their mobility. Their activity in fungi results in large-scale chromosomal rearrangements, horizontal gene transfer, and the movement of genes for pathogenicity, symbiosis, and secondary metabolism. Other YR-elements underwent domestication giving rise to ZMYM transcriptional regulators in animals. Results We identify and characterize the fungal members of the CryptonA lineage of tyrosine recombinase-encoding transposons, which we name Glomhoppers. These elements encode a DUF3504 domain that retains the conserved catalytic residues characteristic of active YRs. In contrast, many domesticated animal DUF3504 homologs lack key catalytic residues, whereas active CryptonA transposon-derived DUF3504 elements have also been reported in animals. Structural modeling suggested the presence of a putative DNA-binding groove, and phylogenetic analyses placed Glomhoppers as a well-supported subclade within the CryptonA lineage, together with domesticated ZMYM-like derivatives. Across 72 Glomeromycota genomes, ~ 1,800 Glomhopper copies were identified, representing a subset of DUF3504-containing loci, mostly truncated or intronized, but ~ 25% lacked introns and maintained intact catalytic motifs, consistent with potential mobility. Genomic context analysis revealed their frequent localization within highly repetitive compartments, often alongside other transposon families. Expression data indicated that intronless variants respond to stress, reaching several-fold higher expression levels than intron-containing forms, especially in Gigaspora species. This is consistent with the possibility that a subset of Glomhoppers remains transcriptionally active and potentially mobilizable, although direct evidence of transposition is lacking. Conclusion Our findings establish Glomhoppers as a novel subfamily of DUF3504-encoding CryptonAs. The lineage-specific distribution, intron variation, and stress-responsive expression of Glomhoppers suggest divergent evolutionary trajectories, potentially including both mobility and domestication. These elements expand the known diversity of YR transposons and highlight DUF3504 as a candidate domain for further functional and evolutionary studies.

doi.org

Happy to share our work! 🍄🍇 Botrytis cinerea grapevine-specialized strains harbor a specific repertoire of transposons. While retrotransposon-derived small RNAs do not appear to play a significant role in virulence on grapevine, a new giant transposon—a #Starship— confers arsenic resistance.

bioRxiv Genomics@biorxiv-genomic.bsky.social · 2mo ago

Role of transposons in the specialization of Botrytis cinerea to grapevine: Insights into small RNAs and a new Starship https://www.biorxiv.org/content/10.64898/2026.05.30.728154v1

We’re hiring! 🇸🇪🔬
 Tenure-track Assistant Professor in Prokaryotic Microbiology (molecular focus) at Stockholm University. Supportive environment + strong molecular research 👉https://su.varbi.com/en/what:job/jobID:921526/type:job/where:125/apply:1 Please share!!

Biträdande lektor i prokaryot mikrobiologi med inriktning mot molekylära processer

Institutionen för molekylär biovetenskap, Wenner-Grens institut (MBW) bedriver experimentell grundforskning inom molekylär cellbiologi, integrativ biologi och infektions- och immunbiologi. Forsknin

su.varbi.com

Some reflections on #Fungal26 This was a great meeting as always but set against some turbulent times of course, which meant many regular attendees were not present. This thread is mainly for them. However, the proportion of first-time attendees was very high and very international. #Fungal26 1/15

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A permanent position as a research scientist is opened in our team! We look for a plant physiologist with expertise in plant / microorganism interactions to identify plant susceptibility factors to fungal disease. Please forward!

@inrae-bioger.bsky.social · 6mo ago

It’s now official! INRAE is recruiting: @inrae-bioger.bsky.social is offering a permanent position as a research scientist to identify #plant #susceptibility factors to #fungal diseases. Visit jobs.inrae.fr/en/open-comp... before March 5, 2026 to apply!