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Fanny Wegner

@fwegner.bsky.social

Viruses, bacteria, fungi, infectious diseases, and evolution. Based in Zürich, Switzerland.

5 Posts258 Follower238 Folgt
Helena Seth-Smith @thebelsian.bsky.social · last yr.

Using a target enrichment approach across a panel of bacterial STIs doi.org/10.1099/mgen... , we have identified a new lineage of LGV Chlamydia trachomatis doi.org/10.1099/mgen... .

Evaluating methods for genome sequencing of Chlamydia trachomatis and other sexually transmitted bacteria directly from clinical swabs

Rates of bacterial sexually transmitted infections (STIs) are rising, and accessing their genomes provides information on strain evolution, circulating strains and encoded antimicrobial resistance (AM...

doi.org

Helena Seth-Smith @thebelsian.bsky.social · last yr.

With love in the air, there is no better time to talk about STIs ;-). I am incredibly proud to present back-to-back papers from my lab, published today in Microbial Genomics.

Evaluating methods for genome sequencing of Chlamydia trachomatis and other sexually transmitted bacteria directly from clinical swabs

Rates of bacterial sexually transmitted infections (STIs) are rising, and accessing their genomes provides information on strain evolution, circulating strains and encoded antimicrobial resistance (AM...

doi.org

Jesse Shapiro@bjesseshapiro.bsky.social · 2y ago

Now published: "Phage predation, disease severity, and pathogen genetic diversity in cholera patients" www.science.org/doi/10.1126/... Check out the podcast to hear co-senior author Eric Nelson talk about the twists and turns of our study (around 18:25): www.science.org/content/podc...

Phage predation, disease severity, and pathogen genetic diversity in cholera patients

Despite an increasingly detailed picture of the molecular mechanisms of bacteriophage (phage)–bacterial interactions, we lack an understanding of how these interactions evolve and impact disease withi...

science.org

Jesse Shapiro@bjesseshapiro.bsky.social · 3y ago

Revised preprint: Phage predation is a biomarker for disease severity and shapes pathogen genetic diversity in cholera patients. To support major conclusions, we repeated key analyses using qPCR instead of metagenomics to quantify phage ICP1 and V. cholerae www.biorxiv.org/content/10.1...

Mild dehydration in cholera patients is associated with a higher ratio of phage ICP1 to V. cholerae. In the absence of ICE-encoded resistance, phage select for nonsynonymous point mutations in the Vc genome. In contrast, severe dehydration is associated with a lower ICP:Vc ratio. Vc encoding ICE-based phage defences select for nonsynonymous points mutations in ICP1.