We are hiring post-docs ! If you are interested in projects at the interface between physics, biology and machine learning (AI ?) please contact me ! More details here www.francoisresearch.org/positions

Happy to share our latest review article, “Learning the Principles of T Cell Antigen Discernment.” www.annualreviews.org/content/jour... with @fxpbourassa.bsky.social , Sooraj Achar and Grégoire Altan-Bonnet ! 1/4

Learning the Principles of T Cell Antigen Discernment

T cells are central to the adaptive immune response, capable of detecting pathogenic antigens while ignoring healthy tissues with remarkable specificity and sensitivity. Quantitatively understanding h...

annualreviews.org

Why do we stop smelling odors that linger? In our new @prxlife.bsky.social paper with @pfrancois.bsky.social, @gautamreddy.bsky.social, and Massimo Vergassola, we develop a manifold learning theory of this olfactory habituation process in fluctuating environments. 🔗 doi.org/10.1103/q62z... 🧵🔽

Last call for postdoctoral applications to join my group at University of Toronto. Feel free to reach out if you want to learn more about the position.

David Hathcock@davidhathcock.bsky.social · 8mo ago

Postdoctoral Job Opportunity! I am hiring a postdoc to join my group next fall. Many possible research directions in theoretical biophysics and nonequilibrium statistical mechanics. See the posting linked below for details — apply by Jan 15th for full consideration.

Very happy to share our 'Evoscape' paper, now published in PNAS ! www.pnas.org/doi/10.1073/...

Generative epigenetic landscapes map the topology and topography of cell fates | PNAS

Epigenetic landscapes were proposed by Waddington as the central concept to describe cell fate dynamics in a locally low-dimensional space. In mode...

pnas.org

"Learning the principles of T cell antigen discernment" a review focused on the theoretical and experimental principles of Adaptive Kinetic Proofreading, with recent application to cancer immunotherapy ! With @fxpbourassa.bsky.social , Sooraj Achar and Grégoire Altan-Bonnet. arxiv.org/abs/2511.18626

Learning the principles of T cell antigen discernment

T cells are central to the adaptive immune response, capable of detecting pathogenic antigens while ignoring healthy tissues with remarkable specificity and sensitivity. Quantitatively understanding h...

arxiv.org

As the march meeting abstract deadline approaches, please check out our session! Please RT/forward

Qiwei Yu@qiweiyu.bsky.social · 11mo ago

For the 2026 APS March Meeting, please consider submitting your abstract to our new focus session on Cellular Sensing and Signaling (04.01.29), which aims to bridge theory and experiments to understand how cells sense and respond to environmental signals.

We are hiring ! If you want to become professor of Bioinformatics in the best city of North America, check the announcement below ! Also you do need to speak French (as long as you commit to learning it :) ) www.umontreal.ca/public/www/d...

Apply now to be a CPBF Fellow in 2026! puwebp.princeton.edu/AcadHire/app...

National Cancer Institute on our venture in Cancer Immunotherapy :) ccr.cancer.gov/news/article...

T-cell receptors can help CAR T cells steer clear of healthy tissue while they attack tumors | Center for Cancer Research

Adding a specific T-cell receptor to CAR T cells may reduce side effects of immunotherapies designed to target solid tumors.

ccr.cancer.gov

"Pour une immunothérapie encore plus précise" : merci à Catherine Couturier et à UdeM Nouvelles pour la couverture de notre récent article, en collaboration avec les groupes Taylor et Altan-Bonnet au NCI ! nouvelles.umontreal.ca/article/2025...

Pour une immunothérapie encore plus précise

Une équipe de recherche réussit à créer une cellule immunitaire plus efficace qui combat les cancers sans toucher aux tissus sains.

nouvelles.umontreal.ca

As promised, a 'skeet' -orial on our paper published last week !

Cell - a Cell Press journal@cp-cell.bsky.social · last yr.

Now online! Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

Now online! Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

Robot-assisted analysis and theoretical modeling of TCR/CAR crosstalk enable the design of adoptive T cell therapies that maximize anti-tumor activity and minimize toxicity in healthy tissues.

dlvr.it

Delighted to share our herculean, collaborative paper, published online today in Cell ! In short, we circle from data to theory back to experiments to design a new anti-cancer immunotherapy. www.cell.com/cell/fulltex...