#ResearchHighlight 🚨 Glioblastoma exhibits sex-specific differences in disease progression, incidence & immune regulation. Pathak et al. identify GABA as a key driver of granulocytic MDSC-mediated glioblastoma progression in women. 👇

GABA takes the edge off anti-tumour immunity - Nature Reviews Cancer

Glioblastoma exhibits sex-specific differences in disease progression, incidence and immune regulation. Now, Pathak et al. identify GABA (γ-aminobutyric acid) as a key driver of granulocytic myeloid-derived suppressor cell-mediated glioblastoma progression in women.

dlvr.it

My latest Research highlight focuses on a study by Wang et al. showing how tumour-associated visceral adipose tissue can act as a reservoir for T cells, limiting their infiltration into tumours. Click below for more deets! 👇

Nature Reviews Cancer@natrevcancer.nature.com · 4mo ago

Check out my latest research highlight 🤓

Nature Reviews Cancer@natrevcancer.nature.com · 5mo ago

#Research Highlight 🚨 Re-routing IgE for cancer therapy: A recent study reveals that mast cells engineered with tumour-specific antibodies and an oncolytic virus can target and kill tumour cells while boosting local anti-tumour immunity. 📖 👇

🚨📖🎗️⬇️

Nature Reviews Cancer@natrevcancer.nature.com · 6mo ago

On #WorldCancerDay 🎗️💕 , we celebrate being #UnitedByUnique. In this #COMMENT, Mansouri, Zadeh et al. outline a framework to embed patients & the public into basic research, strengthening communication, equity and real‑world impact. 👇 📖 http://dlvr.it/TQlvx5

"helping"

We've known for awhile that TACAs are unique markers of cancer.... but targeting them has been challenging. Check out my latest research highlight to find out how Zhou et al. managed it! 😎

Nature Reviews Cancer@natrevcancer.nature.com · 7mo ago

ICYMI: #ResearchHighlight By incorporating lectins that target tumour-associated carbohydrate antigens, Zhou et al. engineered bispecific antibodies that induce effective T cell activation & tumour regression in various cancers. 📖 👇

Happy New Year! 🍾🥳 Our cover (titled "fast and focused killing") is inspired by the Perspective on FLASH radiotherapy. Happy reading! www.nature.com/articles/s41...

Nature Reviews Cancer@natrevcancer.nature.com · 7mo ago

Happy 2026! Our first issue of the year is live! ❄️ It features articles on: - Identifying & targeting EMT tumour states - Metabolic cell death for therapy - Epigenetic regulation of T cell exhaustion - FLASH radiotherapy 👇 📖 https://bit.ly/4jp37...

It seems editing really is a collaborative process 🐈🐈 #purrreviewed

🚨 In light of the #NobelPrize recognizing discoveries in peripheral immune tolerance, our article "Regulatory T cells in the tumour microenvironment" is now free to read. Discover how #Tregs shape cancer immunity 📖 👇

Regulatory T cells in the tumour microenvironment - Nature Reviews Cancer

This Review by Imianowski et al. outlines the various contributions that regulatory T cells, present in the tumour microenvironment, make towards tumour progression and highlight the ways in which they represent attractive next-generation immunotherapeutic targets.

bit.ly

I am currently at BER waiting to board my flight to Portugal for #ESHAML2025! If you're attending too, I'd love to chat about @natrevcancer.nature.com, editorial work in general or just to say hi 👋

Happy Thanksgiving to my fellow Canadians! 🍁🦃🥧

Even after finishing a PhD, the advise still resonated. As an Editor, my advise: read A LOT🤓. You don't need to reinvent the wheel to write a good paper... but you definitely need to slow down & think. Reading helps you contextualize findings, make good experimental plans & explain your science.

Nature@nature.com · 10mo ago

What's one piece of advice you'd give to someone considering a PhD? We asked 3785 doctoral candidates across 107 countries for their hard-won wisdom go.nature.com/4nDjJ7t

T-ALL is notoriously hard to treat due to the difficulty in distinguishing normal and malignant T cells. Now Fuentes et al. identify the pre-TCR as a biomarker for leukemia-initiating cells and develop a targeted immunotherapy for it. 📖👇

Nature Reviews Cancer@natrevcancer.nature.com · 11mo ago

In a rare bout of personal news… I’m finally ready to be active on Bluesky again! Outside of my work-hours, I was a little busy planning a wedding with my cats’ dad 🐈🐈. Photo evidence below 🤭

Our FOCUS issue on #Ageing and Cancer is live! It features articles on: - age-induced metabolic reprogramming in cancer progression - modelling ageing-related cancer evolution - stromal senescence in age-related cancer Read it now: http://bit.ly/48uIDB...

Our SEPTEMBER issue is live! 🌤️🍂🌻🍂 It features articles on: - ER stress responses in anti-cancer immunity - Regulatory T cells in the TME - Metabolic adaptations of brain metastasis - Engineering strategies for nanoparticles Read it now👇 bit.ly/4mW1JnQ

Put on Tom & Jerry so my lil sidekick Leonard would let me work in peace. She was more into it than I thought she'd be 😹

🤩 It was a pleasure handling this article, and I am equally excited to see it out! Congrats!!!

Sandra McAllister, PhD@sandramcallister.bsky.social · 12mo ago

It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful. Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support

Exercise induces microbiota to produce formate which in turn enhances CD8+ T cell anti-tumour functionality. 💪 #gains Check out my research highlight below for more deets 🤓🐛🧫

Nature Reviews Cancer@natrevcancer.nature.com · last yr.

NEW content online!

#REVIEW 🚨 #Nanoparticles can be engineered for targeted delivery of cancer therapies. Gomerdinger, Nabar & Hammond explore how surface chemistry drives delivery, targeting & localization. 📖 👇

Advancing engineering design strategies for targeted cancer nanomedicine - Nature Reviews Cancer

Nanoparticle surfaces can be engineered for targeted delivery of cancer therapies. In this Review, Gomerdinger, Nabar and Hammond outline the role of surface chemistry at all levels of nanoparticle trafficking, from administration route, to tissue accumulation, cellular targeting and ultimately subcellular localization. They emphasize the utility of non-covalent surface modifications for improving stealth and targeting abilities of nanoparticles for cancer.

nature.com

August?! How did that happen?! I am still waiting for summer to arrive in Berlin😫 In any case, this issue is a goodie. Give it a read!! 🤓📖✨

Nature Reviews Cancer@natrevcancer.nature.com · last yr.

Our AUGUST issue is live! 🥵 🏖️ 🌞 It features: - A #roadmap on acquire resistance in cancer - A #persepective on gender and sex in cancer phenotypes - A #review on neuro-immune crosstalk in cancer - A #review on γδT cell signaling for cancer immunotherapy

In this Comment, Grünwald & Khokha call for a shift in comprehension of tumour tissue organization; while tumour tissues are heterogeneous, they are not disordered, & instead, propagate their functions via a considerable level of self-organization. 📖 👇 https://bit.ly/4nZaQ...

I previously volunteered w men returning from prison, where I saw how often adolescent hardships shaped their paths. Incarceration should not make someone undeserving of care & denying medical treatment reflects societal bias + ignorance. 📖⬇️ the barriers to equitable care for those behind bars.

Nature Reviews Cancer@natrevcancer.nature.com · last yr.

People in the USA who are incarcerated, or have a history of incarceration, face worse access to cancer care, leading to poorer outcomes. Zhao & colleagues highlight the need to address these inequities through coordinated action. https://www.nature.c...

A super cool Perspective highlighting the intersection of metabolic hallmarks of both aging and cancer. In it, they also explore how population-related metabolic differences associated with longevity may contribute to racial disparities in cancer risk & prognosis. Give it a read!! 🤓

Nature Reviews Cancer@natrevcancer.nature.com · last yr.

#Perspective 🚨 Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease. ⬇️ 📖 https://bit.ly/3IkNY... @moffittnews.bsky.social‬

pictured here is Leonard watching me watch AACR talks 😹

I will absolutely never understand why you would actively choose to turn off spell check on your Word document.😫 Look, we all make mistakes even with spell check on.... but I can tell you without a doubt that it would *defiantely* benefit you to keep it on.

Check out my latest research highlight 👇 While the presence of tertiary lymphoid structures (TLSs) in tumours is often linked with ⬆️response to IO, the maturation status can influence this. Now, Tang et al. uncover tryptophan metabolism as a factor determining TLS maturation status.

Nature Reviews Cancer@natrevcancer.nature.com · last yr.

NEW content online!

Nature Cuteness 🥹

Springer Nature@springernature.com · last yr.

From Chief Editor of Nature Cuteness to Nap Quality Control Officer. To give our colleagues a break to celebrate #SpringerNature10, we put the #PetsOfSN to work across our teams. All dogs, cats & bunnies were of course generously paid in tasty treats, belly rubs & cuddles. #PetsOfSN10 🐶 🐱 🐰

REVIEW🚨 Rodriguez, Cubillos-Ruiz &Co discuss how the #ERstress response affects intratumoural immune cells & highlight the potential of #UPR-targeted interventions to improve cancer outcomes. 👀⬇️

Endoplasmic reticulum stress responses in anticancer immunity - Nature Reviews Cancer

The endoplasmic reticulum (ER) has a central role in mounting effective and durable antitumour immunity. In this Review, Hwang et al. outline how tumour-induced ER stress responses alter the function of intratumoural immune cells and the efficacy of immunotherapy, highlighting the potential of unfolded protein response-targeted interventions to improve cancer outcomes.

bit.ly