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Michael Gantier

@gantierlab.bsky.social

Research group at Hudson Institute of Medical Res. - Nucleic acids innate immunity

7 Posts349 Follower90 Folgt
Michael Gantier@gantierlab.bsky.social · 5mo ago

A great summary about our recent Nature Immunology paper on TLR7/8 natural antagonism, thanks to Maialen Sebastian-delaCruz! New Checkpoint in TLR7/8 Sensing Rewrites Innate Immune Rules signals.cytokinesociety.org/2026/03/14/g...

New Checkpoint in TLR7/8 Sensing Rewrites Innate Immune Rules - Biweekly newsletter of The Cytokine Society

A study from the Gantier lab (Hudson Institute/Monash University), published in Nature Immunology, reveals that naturally occurring 2′-O-methyl-guanosine RNA fragments act as potent antagonists of TLR7 and TLR8, binding a previously unknown site to keep the receptors in an inactive state.

signals.cytokinesociety.org

Art Krieg@artkrieg.bsky.social · 5mo ago

The implications are profound, and go beyond TLR7/8: TLR9 uses the same basic design to discriminate self/nonself DNA. Together, TLR7/8/9 must be the key system to distinguish between retroviral particles and normal exosomes: evolution HAD to come up with a way to do this.

@corrylab.bsky.social · 6mo ago

How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff? Our latest paper with @gantierlab.bsky.social shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐ www.nature.com/articles/s41590-026-02429-2

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity - Nature Immunology

Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

nature.com

Molecular Therapy Family of Journals@moltherapy.bsky.social · last yr.

#MTNA

IsomiR stoichiometry changes as disease biomarkers.

Gantier, Gearing and colleagues demonstrate, through analysis of small RNA sequencing data, that quantification of microRNA isoforms enables identification of accurate biomarker candidates overlooked in aggregated microRNA data. A ratio-based approach to isoform-level biomarker discovery is presented, measuring the relative abundance of alternate isoforms to provide internal normalisation within a microRNA.

dlvr.it