Tessera

Sylvie Ricard-Blum started the last workshop for today at #MBE2026 — a fabulous talk on known and maybe-not-yet-known interactions of endostatin, and the wider scope of PPIs in the ECM. Now eagerly waiting for the publication of the teased tool created in collab with @valerioizzi.bsky.social 😉

Sylvie Ricard-Blum giving a talk at Matrix Biologe Europe 2026

The UniProt database has network problems for the second time in 3 weeks. Anyone know anything? This DB is so essential to a protein biochemist's daily work, I can hardly imagine working without it 😬 #biochemistry #protein

Workshop #1 at #MBE2026 featured @tranejoan.bsky.social and @collagenyoshi.bsky.social back-to-back: first a wonderful talk on collagen trafficking, then a deep dive into lysine hydroxylation in collagens — asking the important question of how lysyl hydroxylases recognise their specific targets.

Joan Chang giving a talk at MBE 2026 in Oulu.

Yoshihiro Ishikawa giving a talk at MBE 2026 in Oulu.

Joan Chang @tranejoan.bsky.social · last mo.

@nabalabuic.bsky.social starts the second day at #MBE2026. I already spotted the first protein structure so I am in 😉

Alexandra Naba giving a talk a the MBE 2026 in Oulu.

What a wonderful first #ECR session hosted by @themeshwork.bsky.social! Join in the vibrant community and the future of #ECMatrix is super bright! #MBE2026

Just arrived at #MBE2026 in time for Fiona Watt's talk. Missed @valerioizzi.bsky.social's intro and the first session though — today literally every part of my transport chain was delayed 🤷 Looking forward to an exciting week of science at beautiful @oulu.fi.

A photo of a conference notebook and a sticker of Oulu University, as given to every conference participant.

Jan Gebauer @gebauer.bsky.social · 2mo ago

Yesterday on my way to work... Who else thinks "Astrid Lindgren"? 🤣

A man rides an e-scooter away from the camera down a gravel park path on a sunny day, a large metal floor fan strapped to his back like a backpack, its blades spinning.

This year's #crystallography course is in full swing. We swapped experimental phasing for #NMR and, for the first time, local #AlphaPulldown. But the real essential for an IT-heavy course is the snacks — and we're well stocked.

First full day of the #GRC #Collagen, obviously can't share anything, but there were already amazing talks!

Photo into the lecture hall of for the GRC Collagen

Gabriele Corso@gcorso.bsky.social · last yr.

This sounds really interesting! Eager to test it with some structures we have lying around. 👍

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Richard M. Carpiano, PhD, MPH @rmcarpiano.medsky.social · last yr.

Okay, it's officially summer in Cologne, when I have to move our CryoEM machine from my office to an air conditioned room... ☀️(In Winter I am using it's heat for saving a little on heaters)

Do we really age in bursts like that recent study suggests? @drjenndowd.bsky.social yet again provides a terrific overview and explainer of that study. 🛟🧪 medsky 😷demography sociology

Are we really aging in bursts?

If you are nearing 44 or 60, don't panic.

jenndowd.substack.com

DGMB @matrixbiologie.bsky.social · last yr.

There is an #science feed and #ML in structural biology feed, but is there an protein #crystallography feed? And if not would we need one 🤔

Congratulations to this year’s winner of the Young Investigator Award: Kristina Bubb from Cologne! @nystromlab.bsky.social

Roland Dunbrack 🏳️‍🌈@rolanddunbrack.bsky.social · last yr.

I added support for Boltz1 so we can calculate ipSAE and other scores for pairwise protein-protein interactions on AF2, AF3, and Boltz1 models. Will add nucleic acids eventually. github.com/DunbrackLab/...

GitHub - DunbrackLab/IPSAE: Scoring function for interprotein interactions in AlphaFold2 and AlphaFold3

Scoring function for interprotein interactions in AlphaFold2 and AlphaFold3 - DunbrackLab/IPSAE

github.com

Roland Dunbrack 🏳️‍🌈@rolanddunbrack.bsky.social · last yr.

🧵 on our preprint: Zhang & Skolnick's TM score for comparing model of protein to experimental structures of same protein. The d_j are essentially the same as the aligned error in Alphafold. After any structure alignment, it's the displacement of model Calpha from experimental Calpha of residue j.

Get your data out now! 🚀 BMC has a special edition on “The Extracellular Matrix,” and I’m honoured to guest edit. We’re accepting manuscripts on all aspects of ECM, but if you know my background, you’ll know I’m especially excited about structural data and collagens 😉. [1/2]

Call for papers - The Extracellular Matrix

biomedcentral.com

A worrying talk about the (planned) deregulation of synthetic biology by the EU commision (and worldwide) from Margret Engelhard (from BfN ) at the #38C3. I am working with GMOs daily, but IN the lab and I am not a fan of releasing them ... media.ccc.de/v/38c3-let-s...

Let's build dodos! How generative AI is upturning the world of synthetic biology and hopelessly overwhelming traditional governance instruments.

Have you always wanted to build an egg-laying woolly milk sow or bring the legendary dodo back to life? The dream of some biologists to ...

media.ccc.de

Just heard a talk about #AquaCloning , sounds more like magical cloning. Mostly, Gibson without ANY enzymes. Has anyone tried it in realilty? How good does it work? #Genetics #MolecularBiology journals.plos.org/plosone/arti...

AQUA Cloning: A Versatile and Simple Enzyme-Free Cloning Approach

Assembly cloning is increasingly replacing conventional restriction enzyme and DNA-ligase-dependent cloning methods for reasons of efficiency and performance. Here, we describe AQUA (advanced quick as...

journals.plos.org

We have an annual window decoration competition in our biochemical institute. This is our contribution - I think it represents our group very nicely. #StructuralBiology #XMAS #XRAY #CryoEM

A window decoration stating merry xmas or - as an alternative reading - merry xmas written with 3D printed PDB letters. There is more StruBio related decoration.

We are thinking of reorganising our #MX Master course to integrate a bigger variety of #structuralbiology. Namely #crystallography, #modelling and #NMR (our CryoEM guys still want to do their own thing 😉).