Tremendous news from the American Society of Clinical Oncology meetings for head and neck cancer patients, lung cancer patients and possibly brain and gastric cancers:

Chise@sailorrooscout.bsky.social · 2d ago

GOOD NEWS! A new cancer treatment has demonstrated unprecedented results in a large trial for cancer patients whose disease has become resistant to chemotherapy AND immunotherapy. Tumors shrank in OVER a third of participants, with 15 patients experiencing COMPLETE eradication of their tumors.

More on Uniprot: bit.ly/uniprotprotp... More on other tools for working with proteins: thebumblingbiochemist.com/365-days-of-...

Basics of UniProt, ProtParam & other free online database tools every protein biochemist "needs"

https://www.youtube.com/watch?v=f75f6QCe1gA https://youtu.be/f75f6QCe1gA The protein biochemist’s toolbox almost definitely includes UniProt & ProtParam. So here are some of the basics of using the...

bit.ly

The UniProt basket helps you quickly re-find and work with sequences/ entries you're interested in and the toolbox helps you quickly view, modify, and/or rerun alignments, BLASTs, and ID mappings. youtu.be/sWUIUgp2Ak4

UniProt Basket and Toolbox

YouTube video by the bumbling biochemist

youtu.be

Bluesky is a "liberal bubble" because fascist chuds can't get traction without algorithmic assistance and because people here trained themselves to block "debate me" trybois the instant they roll up

The Verge@theverge.com · 2d ago

Bluesky's new CEO Toni Schneider on the platform's reputation for being a liberal bubble: "Yes, we definitely want that to change. It is already changing. It certainly wasn’t designed to attract one specific group of people."

Progressives: We support gay people! Progressives: We hate MAGA! Progressives: MAGA men are all closeted gays. Gay people: Stop indulging your homophobia to make fun of MAGA men. Find another way. It's not that difficult.

So this is where the E in E coli comes from.

c0nc0rdance@c0nc0rdance.bsky.social · 4d ago

He can properly be called "the first pediatric infectious diseases physician" & he's one of those largely unsung heroes of science & medicine who saved millions of lives with his research & advocacy. The /opposite/ of RFK, Jr., in other words.

If you live or work in Eastern, PA and are anything other than obviously white, stay away from Schuylkill Haven borough. The police are a full blown division of ICE at this point. They pull over anyone who is black or brown and anyone with out of state tags. Pure unadulterated profiling.

I honestly wish the folks developing AI protein design and structure prediction tools would learn how to FORMAT A FRICKING MMCIF FILE correctly.

Seems really interesting. Immune system cells of different types exchange protein antigens. Nature Comms took 15 months to publish the paper. I always wonder if that long delay was worth it, or did it just delay science for the whims of Reviewer #3? www.nature.com/articles/s41...

B cell CD19 is transferred between immune cells in mice and humans - Nature Communications

Trogocytosis enables the transfer of membrane-bound antigens during pathogenic B-T cell interactions. Here, the authors utilize mouse and human cell models and demonstrate that the B cell marker CD19 ...

nature.com

The Onion minion

Roadkill car-paccio

Brandy Zadrozny@brandyzadrozny.bsky.social · 6d ago

Someone posted this in slack and I actually thought it was The Onion. www.usatoday.com/story/news/p...

At 11 pm EDT (Tuesday) in the United States, 1 pm (Wednesday) in Sydney, Australia. Starts in about 40 minutes.

Kate Michie@kmichie.bsky.social · last wk.

Excited to hear @rolanddunbrack.bsky.social talk today ( 1 pm Sydney time) on “Structural bioinformatics and AlphaFold modeling of the human kinome and its interactions” at the Australian Structural Biology Computing community meeting. Details to join the talk:

Remember when NIH Director Jay Bhattacharya said there were no banned words and NIH Program Officers were making them up? Here’s the proof he lied: apnews.com/article/cali... I know, Jay Bhattacharya lying is not news. But it’s still really validating to have the admission.

White House admits it used keywords to kill billions worth of California research grants

Federal agencies that terminated more than a thousand research grants at the University of California last year admitted that they used keywords related to diversity, gender, vaccine hesitancy and COV...

apnews.com

the official who is writing science policy for the nation is a 39 year old Peter Thiel protege with a BA in political science and no experience in either academic or private sector research en.wikipedia.org/wiki/Michael...

Michael Kratsios - Wikipedia

en.wikipedia.org

Go Birds!

@fionatribe.bsky.social

Is ANYONE capable of critiquing the gender politics of the Trump administration without just calling them fags? Because this shit is so fucking stupid and ugly. Straight people staying shitty forever I guess...

MeidasTouch@meidastouch.com · 3w ago

Balint on Hegseth's obsession with testosterone and his attacks on women in combat: "I think it is indicative of the fact that there are so many people in this administration that have some weird, intense, homoerotic, feelings towards men while also being incredibly homophobic..."

@wheelerlab.org is talking about his effort to build a resource for protein dynamics (PDB for MD). MDRepo is a repository to store simulation data. This is really needed to push the needle in design, function and more. Please help make it successful by sharing your MD data. #ismb2026 🌐 mdrepo.org

THS THDPSSSSPS.

Dr. Jeroen W.P. Wijnendaele@drdragases.bsky.social · 3w ago

I am once again begging Hollywood to stop using the Greek alphabet for an Ancient World movie, if they can't afford to even throw a couple of quid at anyone with an inkling of the language. Unless they really think audiences are dying to see THS THDPSSSSPS

The thing I don’t like about Union Station is that the elegant hall in the front is used for no purpose whatsoever, while the area by the entrance to the tracks is like a rundown Greyhound Station. Also there were 4 National Guard troops in the Dupont Circle metro doing nothing and looking bored.

I am once again begging Hollywood to stop using the Greek alphabet for an Ancient World movie, if they can't afford to even throw a couple of quid at anyone with an inkling of the language. Unless they really think audiences are dying to see THS THDPSSSSPS

@rolanddunbrack.bsky.social is talking about kinases and interface scoring (ipSAE). AF’s ipTM score avg. PAE over the full area not just the interface, so disorder and extra domains drag it down. ipSAE uses a PAE cutoff to avoid low scores, therefor only consider good interface contacts. #ismb2026

“Progressives” love to accuse every MAGA guy as gay, not realizing that by doing so they are doing it with a dose of their own homophobia. MAGA is bad, so MAGA is gay. I’m sick of it.

Just Some Guy@utopianparallax.bsky.social · 3w ago

Is ANYONE capable of critiquing the gender politics of the Trump administration without just calling them fags? Because this shit is so fucking stupid and ugly. Straight people staying shitty forever I guess...

It’s hypocritical, but of course totally expected, that the man who leads CDC & NIH, Jay Bhattacharya, used to be a health disparities researcher HIMSELF at Stanford but now he has BANNED such research because, as a MAGA/MAHA activist & staunch Trump/RFK Jr ally, he believes it is just “woke DEI” 👀

Princess Vimentin PhD | Cancer Biologist@princess-vimentin.bsky.social · 3w ago

Global health inequities are a significant factor in increasing cancer rates. This is why we need health disparities research, which is now banned from federal funding. Another factor to consider is that cancer surveillance has improved. 🧪 archive.today/LNKxT

'The Rowling Effect' The UK is now more anti-trans than, not only most European countries, but also countries ranging from Thailand, Japan and the USA, to Colombia and Turkey.

HighDB: a structure-annotated cyclic peptide database for comparative analysis, template retrieval, and design-oriented applications link.springer.com/ar... --- #proteomics #prot-paper

Excited to welcome Prof @rolanddunbrack.bsky.social (@foxchasesurgonc.bsky.social) to our next #StructuralBiology Community Meeting! They’ll be presenting: "Structural bioinformatics and #AlphaFold modeling of the human kinome and its interactions." 29 July, 1pm AEST. All welcome! Agenda & link👇

MEETING: Australian Structural Biology Computing Community — Australian BioCommons

Join the quarterly meeting of the Australian Structural Biology Computing community. More information

biocommons.org.au

I work at Google DeepMind. This won't make me popular. But it's all public reporting: 2014: DeepMind reportedly sold to Google on conditions: no military use, independent oversight 2026: a Pentagon contract for "any lawful government purpose" Not one safeguard survived intact

Must be an Onion headline