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GenomeTDCC

@genometdcc.org

Technology Development Coordinating Center at NHGRI. Advancing innovation in genomic technology development through collaboration, promoting standards, and outreach in conjunction with The Jackson Laboratory 🧬💻🧪

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Sudarshan Pinglay@sudpinglay.bsky.social · 2mo ago

How much of the human genome is essential? Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome. biorxiv.org/content/10.6... nature.com/articles/d41...

Why a synthetic human genome is still worth building

A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.

nature.com

GenomeTDCC@genometdcc.org · 4mo ago

Final session of the Genome Technology Development Webinar Series APRIL 7 @ 1PM ET register: www.jax.org/genometechdev26 This webinar will explore how regulatory DNA, RNA, and nuclear architecture intersect to shape biological function and disease mechanisms. 🧪💻🧬👩‍🔬 Supported by NHGRI and @jax.org

Upcoming Webinar: Exploring How Genome Organization Shapes Biological Function Free registration: www.jax.org/genometechdev26 Join us for an exciting webinar bringing together leading researchers who are uncovering new layers of genome regulation and nuclear organization. Featured Speakers & Talks: Martha Bulyk – Revealing additional layers of cis‑regulatory codes governing transcription factor interactions Wenyi Feng – Linking cytoplasmic single‑stranded DNA detection to Fragile X Syndrome pathology Mitchell Guttman – RNA promotes the formation of spatial compartments throughout the nucleus This webinar will explore how regulatory DNA, RNA, and nuclear architecture intersect to shape biological function and disease mechanisms.
The Jackson Laboratory@jax.org · 4mo ago

Huge congratulations to Mark Adams, professor and interim scientific director at The Jackson Laboratory for Genomic Medicine, who has been elected a 2025 Fellow of @aaas.org — one of the most distinguished lifetime honors for scientists. 🎉 🧪

Mark Adams honored as 2025 AAAS Fellow for his contributions to genomics

At The Jackson Laboratory, Adams’ leadership in genomics builds on a career of pioneering work in DNA sequencing and genome mapping that has helped lay the foundation for modern precision medicine

go.jax.org

GenomeTDCC@genometdcc.org · 4mo ago

The Genome Technology Development Webinar Series. 👉 www.jax.org/GenomeTechDev26 👈 Three webinars featuring leading scientists discussing current capabilities, ongoing challenges, and future opportunities in genome technology innovation. Roundtable discussion following the presentations 🧪🧬💻👩‍🔬 #edusky

GenomeTDCC@genometdcc.org · 5mo ago

Have you registered for the Genome Technologies Development Webinar Series?? 🧪🧬💻👩‍🔬 www.jax.org/GenomeTechDev26 Each session includes scientific presentations and a roundtable discussion examining current capabilities, ongoing challenges, and future opportunities in genome technology innovation.

The TDCC in conjunction with NHGRI and The Jackson Laboratory invite you to the free Genome Technologies Development Webinar Series. Registration: www.jax.org/GenomeTechDev26 Rapid advances in genomic analysis have increased the efficiency, accuracy, and depth of biological discovery, and these improvements are driven by innovative approaches in spatial profiling, single-cell genomics, functional genomics, and genome organization. This series brings together experts whose research continues to expand the frontiers of genome technology. The sessions are designed for postsecondary students, postdoctoral fellows, and biomedical researchers who are seeking a deeper understanding of how emerging tools are developed, applied, and refined. Each event includes scientific presentations and a roundtable discussion that examines current capabilities, ongoing challenges, and future opportunities in genome technology innovation. Revealing Biological Complexity Through Spatial Profiling 26, MARCH 3:00 – 4:00 PM ET Speakers: Fei Chen, Ph.D. Roy Wollman, Ph.D. Moderator: Ramalakshmi Ramasamy, Ph.D. Charting Cellular Futures: Lineage Recording and Regulatory Network Insights 31, MARCH 2:00 – 3:00 PM ET Speakers: Jay Shendure MD, Ph.D. Jason Buenrostro, Ph.D. Moderator: Yashwanth Ashok, Ph.D. Exploring How Genome Organization Shapes Biological Function 7, APRIL 1:00 – 2:00 PM ET Speakers: Martha Bulyk, Ph.D. Wenyi Feng, Ph.D. Mitch Guttman, Ph.D. Moderator: Inés Patop, Ph.D.
GenomeTDCC@genometdcc.org · 9mo ago

Captify: A new platform to study chromatin readers in the nucleosome context 🧪💻🧬 Recently published in Nucleic Acids Research @narjournal.bsky.social, the folks at @epicypher.bsky.social discuss development & integration of these easily adoptable biochemical and genomic tools doi.org/10.1093/nar/...

Nucleosome context regulates chromatin reader preference

Abstract. Chromatin is more than a simple genome packaging system but rather locally distinguished by histone post-translational modifications (PTMs) that

doi.org

GenomeTDCC@genometdcc.org · 11mo ago

SO many great talks from leading scientists who develop and use various genomic technologies. 🧪🧬💻👩‍🔬 Genome architecture, RNA regulation + modification identification, nanopores, DNA writing, statistics, sequencing! It's all there on the GenomeTDCC YouTube channel! www.youtube.com/playlist?lis...