Gerecht Lab
@gerechtlab.bsky.social
< https://gerechtlab.duke.edu/ > Vascular Tissue Engineering | Tumor Microenvironment | Polymeric Biomaterials @ Duke University | Account moderated by SG & trainees
We are pleased to share our most recent publication by postdoc Jiyeon Song! 🧪 We used a 3D vascular network model featuring on-demand stiffening to investigate whether matrix stiffening alone can induce vascular senescence Read more here: advanced.onlinelibrary.wiley.com/doi/10.1002/... #scisky
Our July Journal club ⬇️🧪 "4D force patterning enables spatial control of angiogenesis" www.pnas.org/doi/10.1073/... #scisky #academicsky
Check out our latest publication: an artery-on-chip (ARTOC)! Our ARTOC mimics mechanical and functional properties of smooth muscle and can be used to model two separate vascular diseases: polycythemia and Hutchinson-Guilford Progeria Syndrome 🫀🧪 advanced.onlinelibrary.wiley.com/doi/10.1002/...
For our June Journal Club, we discussed "Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies" from the Stahl Lab! www.nature.com/articles/s41...
Our latest paper is out now in Nature Biomedical Engineering! Co-led by Ying-Yu Lin and Parker Esswein, we developed a protocol to differentiate human induced pluripotent stem cells into retinal endothelial cells (iRECs) & showcase applications. Check it out here: www.nature.com/articles/s41...
Our latest work, led by Dr. Connor Amelung, explores the impact of in situ stiffening on vascular networks and found that stiffening reduced pericellular remodeling by endothelial cells. Our findings have implications in aging & fibrosis #scisky 🧪 advanced.onlinelibrary.wiley.com/doi/full/10....
Dynamic Matrix Stiffening Reprograms Endothelial Angiogenic Remodeling via α2‐Integrin Mechanotransduction
Dynamic extracellular matrix stiffening reprograms endothelial progenitors from a matrix-remodeling, angiogenic state to a stress-adaptive phenotype. Using phototunable hydrogels and functional force...
advanced.onlinelibrary.wiley.com
We are excited to share our new study led by postdoc Jiyeon Song using mechanically tunable hydrogels, multimodal OCT, and deep learning for non-invasive, real-time tracking of granulation tissue formation and vascular remodeling during wound healing 🎉🧪 #scisky www.cell.com/cell-biomate...
Multimodal OCT with deep learning reveals in vivo healing dynamics in hydrogel-treated wounds
Wound healing involves complex biological changes beneath the skin surface that cannot be captured by visual inspection alone. This work presents an AI-powered, non-invasive imaging platform to track ...
cell.com
We are celebrating Dr. Connor Amelung's successful defense! Congratulations and we are so very proud. Excited to see all you accomplish in your next role, and we will miss you! 🧪 #scisky #academicsky
Congratulations to Dr. Travis Brady on his fantastic defense!! We are so incredibly proud of him and his accomplishments and can't wait to see what he does next. 🧪🫀🥹 #scisky #academicsky
Our February journal club! 🧪 We discussed human blood vessel organoids ⬇️ www.cell.com/cell/fulltex... #scisky #academicsky
Our January Journal Club! We discussed the role of cystine in vascular growth and repair 🧪🫀 #scisky www.cell.com/cell-metabol...
Mechano-Senenscence Notch as a mechanosensor for Matrix Stiffness in Endothelial Cell in 3D Col-MA/HA-MA Hydrogel Light-inducible crosslinking/stiffening Stiffness-induced SASP in 3D EC distinct from canonical pro-inflamm SASP @gerechtlab.bsky.social bioRxiv 2025 www.biorxiv.org/content/10.1...
As we enter 2026, we are reflecting back on the past year and all we have achieved! It was a year filled with challenges but also immense growth and accomplishment by our trainees. Here's to a productive and fulfilling 2026 🥂🎉🧪 #scisky #academicsky
Huge congratulations to postdoc Yaqing Huang who was awarded a postdoctoral fellowship from the American Heart Association! She will be studying persistent endothelial cell activation during fibrosis. We are so proud! 🫀🧪 #scisky #academicsky
Happy Holidays from the Gerecht Lab! Wishing everyone a safe and relaxing end of the year #academicsky #scisky 🧪☃️
Congrats to postdoc Jenn for winning 1st place poster in Bladder Physiology at her first CAIRIBU conference! 🧪 #scisky #academicsky
Happy Halloween!! The Gerecht Lab’s Louvre Heist Crew stole the show at this years’ BME Department Halloween party 🦺💎
Our very first Gerecht Lab Bakeoff was a huge success!! 🧁Congratulations to winner Makenzie who made delicious rice krispies! We had a fantastic variety of entries with lots of creativity on show. #academicsky
A full house for our October journal club! We discussed an organotypic atlas of human vascular cells 🧪🔬🫀 #scisky #academicsky www.nature.com/articles/s41...
Congratulations to PhD Candidate Parker Esswein for winning First Place Poster Award at the Bioengineered Tissue Systems & Models Meeting at Cold Spring Harbor! We are so proud 👏🧪 #scisky #academicsky
We are having a great time at the Bioengineered Tissue Systems & Models Meeting at Cold Spring Harbor! PhD candidate Emily Warren presented her work on endothelial cell and pericyte crosstalk. 🧪🔬 #scisky #academicsky
🚨New Gerecht Lab Pub!🚨 Check out our latest work where we demonstrate that direct endothelial cell-pericyte contact in the retina downregulates VEGFR2 in endothelial cells, promoting barrier function 🧪 #angiogenesis #retina #scisky iovs.arvojournals.org/article.aspx...
Congratulations to our newest PhD Candidate, Marcos Negrete, who passed his prelim last week! He has made some incredible progress in his work on vascularized prostate cancer organoids 🧪🔬 #scisky #academicsky
Our September Journal Club! We discussed small-diameter artery grafts engineered from pluripotent stem cells #scisky #academicsky 🧪🔬🫀 www.cell.com/cell-reports...
We are welcoming two new undergraduate researchers this fall! Welcome to Carmen and Fernando 🧪🎉🔬 We are excited to see what they accomplish! #scisky #academicsky
Our August Journal Club! ☀️ We discussed functional roles for senescent cells across the body #scisky #academicsky 🧪🔬 www.cell.com/cell/fulltex...
Congratulations to our postdoc, Jenn, who received the Duke KURe Fellowship in benign urology! #scisky 🧪🔬🎉 We are very excited to see her new project develop!
Jenn Hammel@jennhammel.bsky.social · 12mo agoI'm very excited to share that I've been selected as a Duke University KURe Scholar! With this funding, I will study the long-term impacts of radiotherapy on the bladder using tissue engineering with the goal of understanding and treating radiation cystitis in cancer survivors #scisky
Congratulations to our postdoc Yaqing who was selected as a Duke Scholar in Molecular Medicine! This nine month training program will give her hands-on experiences and shadowing in the clinic. We're so excited to hear about what she learns and how she'll apply it to her research! 🎉🧪🔬🫀 #scisky
