George Goodwin
@gg9761.bsky.social
Research Fellow, King's College London Studying the neurobiological mechanisms of arthritis pain
We have an exciting opportunity at Wolfson SPaRC for a Postdoctoral Research Associate to join our work on the neurobiology of arthritis pain. A great role for researchers interested in neuroscience, advanced imaging, and collaborative science! www.kcl.ac.uk/jobs/142825-...
Postdoctoral Research Associate (PDRA) | King's College London
kcl.ac.uk
🦴 Living with arthritis pain? We’re starting a new project on arthritis pain and want to learn from your experience. 👉 Which movements trigger or worsen your pain? Please take a few minutes to complete our short survey: forms.office.com/e/qv0tx9LJ1L Your input will help guide our research.
Microsoft Forms
forms.office.com
🦴 Living with arthritis pain? We’re starting a new project on arthritis pain and want to learn from your experience. 👉 Which movements trigger or worsen your pain? Please take a few minutes to complete our short survey: forms.office.com/e/qv0tx9LJ1L Your input will help guide our research.
Microsoft Forms
forms.office.com
I'm hiring! I am seeking a research assistant to support my fellowship research on arthritis pain. You'll join me in the fun, friendly and collaborative @wolfsonsparc.bsky.social 👉More details here: www.kcl.ac.uk/jobs/137085-... ⏰Closing date is 22nd February. #painresearch #pain
Do YOU live with joint pain? Do YOU experience poor pain management? Have you got 2-minutes to tell pain researchers about it? If yes 👉 forms.gle/7NTwma2gnVN1... We hope to gain insight into lived experience for those with joint pain & involve people in our #PainResearch 😃
Looking forward to reading this!! Painless NGF seems to have moved away from p75 and onto TrkA biased signaling. www.biorxiv.org/content/10.1...
biorxiv.org
www.sciencedirect.com/science/arti... Great paper from Jason Ivanusic’s lab: they imaged CGRP fibres in cleared joints and found a major loss of subchondral bone innervation in MIA vs controls—opposite to the idea of NGF-driven sprouting in OA. Does the MIA just wipe out the fibres?
Loss of peptidergic innervation of the subchondral bone in a murine model of MIA-induced osteoarthritis
In the present study, we aimed to determine how osteoarthritis (OA) affects the morphology and distribution of nociceptive nerve endings in the subcho…
sciencedirect.com
Stuart Bevan and I are offering an exciting MRC DTP-funded PhD project exploring the mechanisms of pain in Long COVID. Find out more about the project here: 🔗 tinyurl.com/3caseacv Application deadline: 28th October @wolfsonsparc.bsky.social y.social @kingsioppn.bsky.social sioppn.bsky.social
Neuronal subtype-specific expression of NKG2D ligands, injury models, and axonal degeneration? We have a new preprint @ndcnoxford.bsky.social www.biorxiv.org/content/10.1...
NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons
Nociceptors are primary afferent neurons that sense noxious stimuli. They can be activated by tissue injury as well as the accompanying local immune response. We have shown that following nerve injury...
biorxiv.org
“Love is the answer” #fluorescentfriday 8 µm longitudinal section of the Stellate Ganglion. Neurons expressing tdTomato (red). I love this one—these sympathetic neurons innervate the heart, and the section even resembles a heart emoji ❤️
Hello Bluesky. Thrilled to finally share some exciting news: I’ve been awarded a 5-year Career Development Fellowship from @versusarthritis.bsky.social to investigate the role of silent nociceptors in arthritis pain. More info below in the PR.
Institute of Psychiatry, Psychology & Neuroscience@kingsioppn.bsky.social · last yr.Dr George Goodwin receives @versusarthritis.bsky.social Career Development Award to study the role of silent nociceptors in #arthritis pain www.kcl.ac.uk/news/george-...
www.biorxiv.org/content/10.1...
Psilocybin has no immediate or persistent analgesic effect in acute and chronic mouse pain models
The psychedelic psilocybin may have lasting therapeutic effects for patients with chronic pain syndromes. Some clinical and preclinical data suggest these putative benefits derive from direct analgesic effects. However, this possibility has not been comprehensively tested in preclinical models. Here, we show that psilocybin is not analgesic over a range of doses across multiple pain assays and models of acute and chronic inflammatory, neuropathic, or musculoskeletal pain in mice. ### Competing Interest Statement B.D.H. is on the scientific advisory boards of Journey Clinical and Osmind, and is a paid consultant to Arcadia Medicine, Inc, Tactogen, LLC, and Vida Ventures, LLC. R.C.M. is now on leave from Stanford, functioning as Chief Scientific Officer at Bayshore Global Management. R.C.M. is on the scientific advisory boards of MapLight Therapeutics, Bright Minds, MindMed, and Aelis Farma. International Anesthesia Research Society, https://ror.org/0252rqe04, Mentored Research Award National Institute on Drug Abuse, T32DA035165, P50DA042012
biorxiv.org
Fabulous teamwork with @taamslab.bsky.social! Our findings provide a mechanistic explanation for why JAK inhibitors are better painkillers in #arthritis 🧪🧠 #PainResearch #PainScience #Immunosky
JCI insight@insight.jci.org · last yr.This issue’s cover features work by Leonie S. Taams & team @denklab.bsky.social —JAK inhibitors act directly on human sensory neurons: buff.ly/trWfkCr The image shows iPSC–derived sensory neurons stained with β III tubulin (green), Brn3a (red), and DAPI (blue).
