Our Methods Primer seminar are resuming! Today, March the 20th, we will have Ernest Mordret who will talk about Fine-tuning Protein Language Models for functional classification and discovery.

We are proud to share a recent preprint from our lab: Taxonomic-free metagenome GWAS to identify gut microbiome functions influencing host phenotypes doi.org/10.64898/202... which studies the potential of taxonomy-free GWAS approach of the human gut microbiome, using our implemented tool MOGS.

🚀 Fully Funded PhD Opportunities in AI for Personalized Medicine 🚀 🔹 Applications are officially open for a fully funded PhD position in the MSCA Doctoral Network @mlcare.bsky.social (Machine Learning Computational Advancements for peRsonalized mEdicine)! mlcare.webs.tsc.uc3m.es/projects-and...

Our Methods Primer continue! Today, Dec 5th, we will have Hervé Perdy talking about assortative mating and vertical cultural transmission in genetic studies --discussing the polygenic model and how our estimation of the genetic component of traits is impacted by those two phenomena.

The INCEPTION is organizing its Annual Symposium. This year is about GWAS & beyond! We're happy to have @bpasaniuc.bsky.social, @caina89.bsky.social, Iuliana Ionita-Laza , Sriram Sankararaman, and others, who will talk about tools for understanding the genetic determinants of complex diseases

INCEPTION Symposium 2025 - Research

INCEPTION symposium 2025 - Focus on GWAS: paving the way for the future of genetics.

research.pasteur.fr

Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions. @ggspasteur.bsky.social www.nature.com/articles/s42...

The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals - Communications Biology

Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions...

nature.com

We are happy to share a new paper from our lab: The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals www.nature.com/articles/s42... which investigates environmental effects on microbiome interactions, using our previously published tool MANOCCA.

The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals - Communications Biology

Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions...

nature.com

🧬👩‍🏫 Today, in our Journal Club, we discussed this preprint about multi-trait GWAS finemapping by Matthew Stephens’ Lab Yuxin Zou et al. Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model

Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model

We introduce mvSuSiE, a multi-trait fine-mapping method for identifying putative causal variants from genetic association data (individual-level or summary data). mvSuSiE learns patterns of shared gen...

biorxiv.org

🧬 New multi-trait genetic paper on asthma heterogeneity from Emmanuelle Bouzigon's lab and lead by Raphaël Vernet in the Journal of Allergy and Clinical Immunology Unraveling shared genetics across asthma subtypes and 81 asthma-related traits 🔗 doi.org/10.1016/j.ja...

A new collaborative work with our colleagues from HealthFex! Unraveling shared genetics across asthma subtypes and 81 asthma-related traits - www.jacionline.org/article/S009...

Unraveling shared genetics across asthma subtypes and 81 asthma-related traits

Asthma is a complex and heterogeneous disease with a large spectrum of clinical and biological expressions reflecting the multiple underlying pathophysiologic mechanisms. It can be divided into subtyp...

jacionline.org

📰Journal club Our team discussed “Leveraging the local genetic structure for trans-ancestry association mapping” (Xiao et al., AJHG 2022), which introduces LOG-TRAM, a method that boosts statistical power in underrepresented populations by using local genetic architecture. doi.org/10.1016/j.aj...

Peer review is not quite dead but it’s on life support and the current model of scientific publishing is a burning platform. healthydebate.ca/2025/06/topi...

Is peer-review dead? A scientist’s plea to fix a broken system - Healthy Debate

Peer-review may not be over, but the era of exploitative, opaque and corporatized gatekeeping should be.

healthydebate.ca

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41... Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

This long-shot paper aimed to assess whether common GWAS pipelines are reaching their limits for prediction purposes. The review process was lengthy and painful. We're curious to see how it will fly! All comments are welcome! www.cell.com/hgg-advances...

Polygenic risk score prediction accuracy convergence

Polygenic risk prediction has the potential to transform the diagnosis, treatment, and prevention of many common human diseases. However, the timescale and breadth of this transformation is partly unk...

cell.com

Nice! Add a special relatedness matrix for cross-chromosome correlations to estimate the extra heritability due to assortative mating. Much larger contribution for educational attainment than for fluid IQ. www.nature.com/articles/s41...

For today's journal club, we discussed the LHC-MR (Latent Heritable Confounder MR, rdcu.be/emhYv) paper from @zkutalik.bsky.social group. The study propose a new method to model concordant horizontal pleitropy thus accounting for confounding effect.

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

Nature Communications - Mendelian Randomization approaches are being increasingly refined, but certain statistical limitations hinder their application to GWAS. Here, the authors propose a new...

rdcu.be

We're hiring Pioneer Fellow Postdocs!! Join us at the Pioneer Centre for SMARTbiomed to develop innovative methods in epidemiology, biostatistics, and statistical genetics, working with big biomedical data. international.au.dk/about/profil... #StatGen #Epi #Postdoc #SMARTbiomed

Postdocs in Epidemiology or Statistical Genetics at The Pioneer Centre for SMARTbiomed - Vacancy at Aarhus University

Vacancy at Department of Public Health - NCRR - National Centre for Register-based Research, Aarhus University

international.au.dk

A new study from the lab in collaboration with Michael J Cho from BWH investigating COPD subtypes using multi-trait genetics! www.sciencedirect.com/science/arti...

Identifying chronic obstructive pulmonary disease subtypes using multi-trait genetics

Chronic Obstructive Pulmonary Disease (COPD) has a broad spectrum of clinical characteristics. The aetiology of these differences is not well understo…

sciencedirect.com

Glad to be part of this collaborative piece investigating how genetic effect changes with age! iovs.arvojournals.org/article.aspx...

Thanks to Les Treilles Fondation (www.fondationdestreilles.com) for hosting us for a wonderful retreat to discuss causal inference in genetics with Charles Assad, Brielin Brown, @judithabk6.bsky.social, Anne Rovsing, Matti Pirinen,Marie Verbanck,Xiang Zhou,Chiara Sabatti, and Sriram Sankararaman...

La Fondation des Treilles, un lieu virgilien pour les arts et la pensée

Dans « un paysage du bout du monde » situé dans le Haut Var, la Fondation des Treilles est un lieu qui favorise le dialogue entre créateurs et chercheurs.

fondationdestreilles.com

📢Our unit is opening a postdoc position! All candidates interested in working in the field of Statistical Genetics in the thriving Institut Pasteur Paris campus are welcome to apply !!! For details please check here: research.pasteur.fr/en/job/postd...

Postdoctoral position in Statistical Genetics - Research

JOB DESCRIPTION Applications are invited for a postdoctoral position at the Institut Pasteur within the Statistical Genetics unit of the department of Computational Biology. Our unit addresses methodo...

research.pasteur.fr