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Mike Inouye

@mikeinouye.bsky.social

Computational biologist. Geriatric Millennial. Professor, University of Cambridge. Director of Data Sciences, Baker Heart & Diabetes Institute. British | Australian | American. www.inouyelab.org | Cambridge, UK

781 Posts3485 Follower321 Folgt
The Polygenic Score Catalog@pgscatalog.bsky.social · 2w ago

A big day for ancestry-specific polygenic risk scores in the PGS Catalog, a phenome-wide atlas of scores for 241 traits (1501 PGS)! Check it out 🔗: www.pgscatalog.org/publication/...!

PGS Catalog - Chen HH, Nature (2025) (Publication)

The Polygenic Score (PGS) Catalog is an open database of published PGS and the relevant metadata needed to apply and evaluate them correctly.

pgscatalog.org

Nature@nature.com · 10mo ago

Nature research paper: Population-specific polygenic risk scores for people of Han Chinese ancestry go.nature.com/3WCMp4n

Mike Inouye@mikeinouye.bsky.social · last wk.

Nearly 15 years since starting a group, I've tried to encapsulate our research in a set of publications that best represent the group's 3 major programmes: - Next-generation prediction of disease - Uncovering aetiology through multi-omics - Open and sustainable computational methods and resources

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Mike Inouye@mikeinouye.bsky.social · last wk.

Nearly 15 years since starting a group, I've tried to encapsulate our research in a set of publications that best represent the group's 3 major programmes: - Next-generation prediction of disease - Uncovering aetiology through multi-omics - Open and sustainable computational methods and resources

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George Davey Smith@mendelrandom.bsky.social · 3w ago

Does the (live) shingles vaccine protect against dementia? Fergus Hamilton and colleagues provide important evidence in a new preprint using hospital data from the whole of England in a regression discontinuity design from which we *don't* show evidence of a meaningful protective effect /cont

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Mike Inouye@mikeinouye.bsky.social · 3w ago

Interesting! "By analysing genome-wide data across 62 diseases, longevity and fertility, we show that disease-risk alleles are, on average, associated with reduced longevity and increased fertility." www.nature.com/articles/s41...

Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans - Nature Ecology & Evolution

Despite their detrimental health effects, disease loci persist in human populations. This study shows that disease-risk alleles are generally associated with reduced longevity and increased fertility,...

nature.com

Alicia Martin@genetisaur.bsky.social · last mo.

So excited to see this published! This method was a long time in the making and is now being widely used to balance scale with depth, especially for participants where unbiased sequencing approaches are so much more useful than arrays

Broad Institute@broadinstitute.org · last mo.

Broad scientists developed the Blended Genome Exome (BGE) sequencing method, which delivers high-quality, unbiased data at a lower cost than existing gold-standard methods and makes large-scale genetic studies more feasible. @genetisaur.bsky.social

Linda Kachuri@lindakachuri.bsky.social · 4w ago

📢 #TOPMed e/sQTL atlas is out in @science.org today! Happy to contribute to this amazing team effort and rich resource for the genomics community: 69k cis-eQTL + 35k cis-sQTL across 6 tissues/cell types and diverse ancestries. Still more to discover 😉🧬 www.science.org/doi/10.1126/...

Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed

Most genetic variants associated with complex traits are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we characterized 14,324 RNA-sequen...

science.org

Sasha Gusev@sashagusevposts.bsky.social · 4w ago

Very exciting new method for inferring latent disease trajectories, led by the tireless Dr. Urbut with Natarajan and Parmigiani labs. If you're considering a postdoc in this area talk to Sarah! www.nature.com/articles/s41...

A Bayesian framework for longitudinal EHR and genetic discovery - Nature

A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.

nature.com

Arrianna Marie Planey, PhD MA@arrianna-planey.bsky.social · 2mo ago

From the referenced study: "Women were more likely to complete the PhD before age 30 and delay parenthood after 35, whereas men tended to become parents during doctoral studies and often had three or more children by age 40" link.springer.com/article/10.1...

Starting a PhD and becoming a parent: Gendered life-course trajectories in academic careers - Higher Education

The intersection of doctoral training and parenthood poses unique challenges for early-career researchers, with lasting consequences for gender equality in academic careers. Drawing on a global survey...

link.springer.com

Arrianna Marie Planey, PhD MA@arrianna-planey.bsky.social · 2mo ago

*raises hand in 'geriatric mother who will be almost 60 when her kiddo graduates HS'*

Pedro Beltrao@pedrobeltrao.bsky.social · 2mo ago

Switzerland and the UK making the most of their participation in the EU research funding initiatives with Switzerland tied with Germany for the largest number of grants in life science.

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European Research Council (ERC)@erc.europa.eu · 2mo ago

The results of the Advanced Grants 2025 are here! Out of 3,329 applicants, 319 leading researchers have been awarded an ERC Advanced Grant. Congratulations to all! 🎉 Curious to know more ? 👉 buff.ly/uiU9x5K #ERCAdG #FrontierResearch

Mike Inouye@mikeinouye.bsky.social · 2mo ago

A big welcome to bluesky to @millie-z.bsky.social! Millie is a high flying PhD student analysing whole population EHR data in England looking at the effects of air pollution+COVID19 on disease and its molecular aetiology. Worth a follow! She's also a fellow expat American here in Cambridge 😁

Fight for the Future@fightforthefuture.org · 3mo ago

The move to block the Archive from preserving the news makes zero sense. These news outlets are blocking the Wayback Machine even as they rely on it for crucial reporting… Not to mention we need fact-checking more than ever in the age of AI. www.wired.com/story/the-in...

The Internet's Most Powerful Archiving Tool Is in Peril

As major news outlets cut off the Wayback Machine, journalists and advocacy groups are rallying to protect the Internet Archive’s vast collection of web pages.

wired.com

Mike Inouye@mikeinouye.bsky.social · 2mo ago

Review from the lab just out in Cell Genomics: Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging www.cell.com/cell-genomic... Co-led by fab PhD students Benedetta Felici and Siyuan Chen!

Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging

This review covers how the results of genome-wide association studies are now utilized at multiple scales, informing our etiological understanding at the levels of molecules, cells, and organs. It cov...

cell.com

Mike Inouye@mikeinouye.bsky.social · 2mo ago

Review from the lab just out in Cell Genomics: Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging www.cell.com/cell-genomic... Co-led by fab PhD students Benedetta Felici and Siyuan Chen!

Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging

This review covers how the results of genome-wide association studies are now utilized at multiple scales, informing our etiological understanding at the levels of molecules, cells, and organs. It cov...

cell.com