Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

@macshine.bsky.social talks with Mario Senden about his new project using AI-driven bibliometrics to map the structural organization of neuroscience across 25 years. The field it reveals is at once thriving and theoretically adrift. #neuroskyence www.thetransmitter.org/methods/what...

What a bird’s-eye view of half a million papers reveals about neuroscience

New research uses artificial-intellligence-driven bibliometrics to map the structural organization of neuroscience across 25 years. The field it reveals is at once thriving and theoretically adrift.

thetransmitter.org

Now in press one of my last PhD projects! We traced the neurobiological profile of fMRI BOLD signal variability, a measure that has been related to age, behaviour, disease status, but had not yet been fully contextualised within the brain's multiscale architecture. www.nature.com/articles/s41...

New preprint: "Identifying statistical indicators of temporal asymmetry using a data-driven approach" arxiv.org/abs/2511.15991 _Can we statistically distinguish the forward- versus reverse-time dynamics of a system from a finite time series?_

I once saw a (very interesting) talk about sleep in which the speaker started by saying that we don't really know how to define sleep, and then proceeded to operationalize sleep in flies as basically periods when they are still for a long time. This got me thinking...

Neuromorphic hierarchical modular reservoirs | doi.org/10.1101/2025... How does hierarchical modularity shape computational function? ⤵️

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

🚨The first paper of my postdoc is out now in @elife.bsky.social! 🚨 We explored the role of attention in planning. Thank you 🙏 to the reviewers for their helpful comments & suggestions. Keep your 👀 peeled for additional analyses and our response. elifesciences.org/reviewed-pre...

🔥ATTENTION!🔥 Registration for the 2026 Noosa Brain Workshop is now open! Join us for some amazing science, sun, and surf in one of Australia's most beautiful beach towns. Details: tinyurl.com/arbc5pp6 Check out or incredible list of confirmed speakers. More to come...

"Pat, why do you carry that ridiculous 600mm lens on long hikes?" Buddy, I can see mountains reflected in the eyes of a trailside pika.

Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level). If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...

Interested in Network hubs, cortical hierarchies, and gradients? Ever wonder where they come from? Check our latest review, where we cover different approaches to mapping hubs, models for their evolution, and mechanisms for how they develop: osf.io/preprints/os...

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Biologist folk (especially in evolutionary biology and/or ecology, but it don’t matter): Can you give me your favorite examples of trade offs in biology? Organism or system don’t matter. Primary literature or reviews preferred.

New preprint! Why are long-range connectomic interactions in the cortex dominant in shaping dynamics in some experiments but apparently negligible in others? We (w/ R Maran, @elimuller.bsky.social) address this question by studying a new hybrid model of cortical dynamics. arxiv.org/abs/2506.19800

#ohbm2025 Early Career Investigator Award to @macshine.bsky.social - congratulations, super well deserved!

The diversity of methods we use to probe the brain (epistemologies) naturally leads to clashes in our theories of how the brain works (ontologies). So how do we reconcile this divide and grow into a more unified neuroscience? Here is our take: apertureneuro.org/article/1388...

1/ I'm excited to share recent results from my first collaboration with the amazing @anayebi.bsky.social and @leokoz8.bsky.social ! We show how autonomous behavior and whole-brain dynamics emerge in embodied agents with intrinsic motivation driven by world models.

We are seeking a scientific coordinator for my research group at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig 😊🧠🌈 Could be ideal for a gap year between MSc and PhD or PhD and postdoc! Please out more here: recruitingapp-5218.de.umantis.com/Vacancies/43...?

New preprint modelling suppression depth in binocular rivalry and continuous flash suppression with Hugh Wilson, @macshine.bsky.social, & David Alais

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last yr.

A Minimal Physiological Model of Perceptual Suppression and Breakthrough in Visual Rivalry https://www.biorxiv.org/content/10.1101/2025.05.28.656716v1

When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...

The history and future of resting-state functional magnetic resonance imaging - Nature

This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...

nature.com

Have recent changes led to uncertainty in your future scientific career? Wonder it's like in Australia? Good news! Monash's is seeking to hire talented EMCRs from other countries. Come join a wonderful community of brain mappers & modellers! www.monash.edu/research/eme...

Together with @macshine.bsky.social & @elimuller.bsky.social we have a cool interdisciplinary project on compositional cognition, and we’re looking for a PhD student. More details here www.findaphd.com/phds/project... DM or email any questions Please RT or pass on to interested students. Thanks!

Info theory offers powerful measures for capturing complexity & interaction among elements of a complex system, like the brain! 🧠 Here's our new unified reference for key info-theoretic time series measures ft. 📊 visuals, ➗equations, & 💬descriptions: arxiv.org/abs/2505.13080

New preprint!: "Using matrix-product states for time-series machine learning". arxiv.org/abs/2412.15826 Quick summary below 👇

Preprint 🥳 "A unified imaging-histology framework for superficial white matter architecture studies in the human brain" 🧠 SMW key for brain structure-function links 🤔 understudied because of its complexity 💡 SMW mapping for histology & MRI 🌟 OA 📖 lnkd.in/ef8bGGrF by Youngeun Hwang et al

I wish I could carry the enthusiasm for science from this conversation with me in a cup. Fascinating and contagious!

Mac Shine@macshine.bsky.social · last yr.

I recently had the great pleasure of interviewing Michael Bruchas about an absolutely banger recent paper from his group that tracked down cells in the brainstem that subtlety and precisely control the output of the locus coeruleus. Check out my interview here. I hope you like it as much as I did!

First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ... www.nature.com/articles/s41... Read here: rdcu.be/ek01F

Autonomic physiological coupling of the global fMRI signal

Nature Neuroscience - The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

rdcu.be

🎨🧑‍🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI), plus a guide for creating your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊 anniegbryant.github.io/subcortex_vi...

🚨Webinar alert!🚨 Please join us at the end of the month as we tune in to Finn Creeggan for his talk: AI Meets Biology: Unraveling Biological Mysteries with Artificial Intelligence 🗓 Date: Wednesday, April 30th 🕒Time: 4PM ET Register here for free:👇 forms.gle/M764qEB46TtZ...