Why do B cells make (more) cochlin in RA, SLE and Sjogrens? A really interesting preprint, from @beccabelmonte.bsky.social and Mohini Gray at @edinuni-irr.bsky.social www.biorxiv.org/content/10.1...

Cochlin-Expressing Memory B (COMB) Cells Are Enriched in Autoimmune Diseases and Display a Distinct Activation Profile

Rheumatoid arthritis (RA) is the most common chronic autoimmune arthritis, causing joint damage and affecting multiple organs over time. B cells play a key role in driving the disease by producing aut...

biorxiv.org

Really enjoyed reading this preprint from Emma Davenport and Marina Botto’s labs. scRNAseq + AIRR of rituximab treatment in SLE - www.medrxiv.org/content/10.1...

Single-cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus

Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used in the treatment of systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a dee...

medrxiv.org

*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

Our search for a flow cytometry core facility manager for King's Buildings, University of Edinburgh, is finally live. Join us! Conventional & spectral. Parasites, immune cells, algae, bacteria, yeast and more. Full-time, open-ended. Apply by 17 March. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Our new publication on BCR sequencing in ME/CFS, adding to the evidence of an increased usage of IGHV3-30. Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease. www.frontiersin.org/journals/imm...

Frontiers | Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome

frontiersin.org

It’s wonderful to be at the University of Glasgow today to examine a viva. I think the last time I was here was 18 years ago for my own.

Having a day back in the lab expressing antibodies in Expi293 cells. Very excited to use my new 3d printed flask holder- much better than the old sticky mat!

Looking forward to this- just registered.

Steven Kleinstein@skleinstein.bsky.social · 2y ago

Are you an Immcantation.org user or interested in B cell repertoire analysis? Register now for the 2025 Immcantation Users Group Meeting! The meeting will feature talks from users showcasing how they use Immcantation in their research. Info and registration at: immcantation.github.io/users-meetin...

Welcome to BlueSky @uoe-eid.bsky.social !

Edinburgh Infectious Diseases@uoe-eid.bsky.social · 2y ago

Welcome to our brand new Blue Sky page! We are really excited to be here to engage with our network in friendly, informative and productive ways! Join us 😊

Inspired by @rodrahimi.bsky.social 's noble efforts linking immunologists together over here, let's try and get more specifically TCR/BCR/AIRR/repertoire chat going with this starter park go.bsky.app/Gi2dcGd Drop me a beep to get added or suggest others!