“The whole point of AI tools is that I no longer need to retain information in my biological memory. My biological memory is for other things now. Important things. Like my Netflix password” 😂 inpreparation.substack.com/p/opinion-i-...

Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

inpreparation.substack.com

When I assign a research paper, it's not because I want an essay I can use to evaluate the student ex post. It's because I want the student to have the experience of going through the process of all of the above steps, perhaps iteratively, that is necessary to write a good research paper.

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

Fascinating paper. Not only association between auto antibodies against immunotegulatory IL-10 and some patients with inflammatory bowel disease. But also association between these antibodies and HLA risk allele for IBD. What's mechanistic link? #immunosky #MedSky www.nejm.org/doi/full/10....

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

nejm.org

Immunologist Dr. Teruko Ishizaka co-discovered Immunoglobulin E (IgE) in 1966. This major scientific breakthrough identified the specific antibody responsible for allergic reactions and laid the foundation for modern asthma & allergy treatments. She died #OTD in 2019 at age 92. #WomenInSTEM #medsky

Today Microsoft moved all its GitHub copilot subscribers to token-based billing. If you want to see what happens when people have to pay the actual costs of AI, the day is finally here. It's obvious that every customer sees the deep, meaningful value and isn't angry at all.

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

How much of Thermo Fisher’s antibody data has been manipulated?

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

reeserichardson.blog

Thermo Fisher has now made public the company line, which is ?!??!?!??!?!?! you really gotta read it. cen.acs.org/research-int...

Reese Richardson@reeserichardson.bsky.social · 2mo ago

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

"Please provide a justification for the foreign collaboration." Science.

Roland Dunbrack 🏳️‍🌈@rolanddunbrack.bsky.social · 2mo ago

My PO said I had to fill out this form for 3 of my papers for the RPPR of my NIGMS MIRA grant in February, or I could not include them in my progress report. It looks like things have gotten even worse since then.

NIH funded peeps: This is insane and coming for us.

Delighted that our paper is out @natcancer.nature.com. Research led by Tom Castro-Dopico in partnership with Adendra Therapeutics reporting on a means to increase presentation of antigens from cancer cells. Read it for free at www.nature.com/articles/s43...

Coupling dead cell recognition to Fcγ receptors augments anticancer immunity - Nature Cancer

Castro-Dopico et al. report the design of reagents to bridge F-actin and Fcγ receptors, endowing a range of antigen-presenting cells with the ability to cross-present antigens from dead tumor cells an...

nature.com

The Francis Crick Institute@crick.ac.uk · 3mo ago

Researchers at the Crick have found a way to redirect immune cells using F-actin exposed from dead cancer cells, reducing tumour growth in mice. The technique opens new avenues for developing immunotherapy treatments that complement existing clinical approaches. www.crick.ac.uk/news/2026-05...

share.google/z1eVQD4FVd8W...

University’s £585,000 free speech fine overturned

A university has won a High Court challenge against England’s higher education regulator over a finding that it had infringed

share.google

Researchers led by Drs. Michael Gantier, Toshiyuki Shimizu, and Ben Corry show that modified #RNA from our own cells naturally blocks TLR7 and TLR8, preventing harmful immune activation. 📖: https://go.nature.com/4azVWjp 🔊: https://bit.ly/40muGA2

At the end of 2024, the National Academies put out a report concluding the NIH has woefully underfunded women’s health research, and they suggested $15 B should be invested over the next 5 years. Here’s what’s happened instead. Hard to study women’s health if you can’t say “women.” wapo.st/4euUt1c

www.bbc.co.uk/news/article...

Pregnancy vaccine reduces baby hospital admissions for RSV by 80%

A study confirms the vaccine gives excellent protection for babies against life-threatening chest infections.

bbc.co.uk

Boys should also get the HPV vaccine, not only to help eliminate cervical cancer through building herd immunity but also because in this latest study it cancer risk in men by about half (in 10 years of follow up; the reduction may be larger with longer follow up) jamanetwork.com/journals/jam...

Nine-Valent HPV Vaccination and Related Cancers

This cohort study examines associations of the 9-valent human papillomavirus (HPV) vaccine with HPV-related cancers in males aged 9 to 26 years.

jamanetwork.com

Started this project years ago, but now everything is deposited on @addgene.bsky.social and a short @protocolsio.bsky.social is online. Try it out to make your own (cheap) homemade nuclease/Benzonase! dx.doi.org/10.17504/protocols.io.261ged7xov47/v2 Thank you @jcoker10.bsky.social and Michael Lim!

Mankind can't even escape from terrible work-mandated microsoft products in space

Jeffrey Barrett@jeffbarrett.eu · 4mo ago

Is this real? The audio sounds real. Apollo managed to actually land on the moon using a computer with 4kb of RAM and these poor bastards have to install Outlook updates?

Great tribute to Robin from the Microbiology Society.

Microbiology Society@microbiologysociety.org · 4mo ago

You can now read the Society's full tribute to former President Professor Robin Weiss FRS. Robin was an Honorary Member and, in addition to serving as President from 2006 to 2009, was the winner of the Marjory Stephenson Prize Lecture in 2015: https://microb.io/4dRe7Ei

We are delighted to share that our NIHR-funded project in Kenya has been featured as a flagship impact case study by The University of Manchester. This partnership exemplifies how international cooperation can bridge the gap between laboratory research and life-saving clinical care.

The University of Manchester@manchester.ac.uk · 5mo ago

For Professor Rob Bristow and partners in Kenya, impact began with listening, not importing a UK model. Together, they co‑created a mobile screening approach for oesophageal cancer. www.youtube.com/watch?v=Dt4X...

NIH Fellowship awards for FY2025 by race drugmonkey.wordpress.com/2026/03/19/n...

NIH Fellowship awards for FY2025 by race

The NIH Data Book page reporting Research Project Grants (RPG) and Fellowship awards by race has been updated for FY2025. Completely unsurprisingly, despite the impression that may have been convey…

drugmonkey.wordpress.com

"Yes, Africa has challenges; we have multiple and complex disease burdens, and we have systemic resource and infrastructure issues. But we also have lessons and innovations to share with the rest of the world." www.thelancet.com/journals/lan...

Amplifying African voices to lead science for better health

Despite making up 19% of the world's population, Africa contributes only 1–2% to global knowledge production across multiple fields of research. The terminology of Majority vs Minority World countries...

thelancet.com

That column on the far right is the death of American biomedical science.

Sasha Gusev@sashagusevposts.bsky.social · 5mo ago

Here is the "effective payline" for each institute, estimated (by Claude) as the percentile where one can expect 80% probability of funding from a logistic regression fit. The effective payline has gone from a historic ~12% to 6% in 2025.

🚀 Registration is now OPEN for AIRR Community Meeting VIII: Decoding and Recoding Immunity! Join us June 8–11, 2026 at Yale University (USA) or attend virtually. 💸 Early-bird rates available until April 15! 🔗 Register: tinyurl.com/airrcmeeting8 #AIRRC8 #immunosky

You ever look at the human TCR gamma chain locus and ask why the constant region's so silly? It's doing stuff! www.science.org/doi/full/10.... (Very gratified to see this, having once spent an afternoon making my tool stitchr make sure it can handle the different TRGC isoforms, now feels justified)

This won’t come as a surprise to the TCR-antigen gurus, but I did want to share some lessons we learned re: partial TCR sequence alignments as predictions for antigen specificity from this study 1/

Joe Sabatino@jsabatino37.bsky.social · 6mo ago

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/ www.nature.com/articles/s41...

As mentioned in another thread, four UKRI leaders spoke to journalists this morning about changes to research council funding They addressed stories broken by RPN that STFC has to find £162m of costs savings by 2029-30, and that major physics infrastructure projects have been shelved ...

Research Professional News@resprofnews.bsky.social · 6mo ago

‘Difficult’ two years ahead for physics, warns STFC boss. Michele Dougherty confirms withdrawal from LHC upgrade and indicates scant money for new projects. www.researchprofessionalnews.com/rr-news-uk-r...

Update from MRC re funding

Rob Fagan@robfagan.bsky.social · 6mo ago

They've separately said: Our transition to new ways of working also means we unfortunately expect to make a reduced number of awards to applications currently being assessed by our four research boards and developmental pathway funding scheme. www.ukri.org/blog/mrc-fun...

Unleashing live-cell imaging for the masses! Adapting the OpenFlexure Microscope for Affordable Live-Cell Imaging www.biorxiv.org/content/10.6... Fits into existing incubators for time-lapse experiments & feeds into existing bioimaging analysis pipelines. Thanks @wellcometrust.bsky.social funding

This is finally out. Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year. This is why persistent infections matter www.cell.com/cell-reports...

Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections

Snell et al. develop sequencing methodology to identify full-length spike haplotypes and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence, accelerating viral evolution an...

cell.com