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Grampospath

@grampospath.bsky.social

Streptococcal and Infectious Diseases research at Imperial College London- and Infectious Diseases Physician #strepA

19 Posts93 Follower89 Folgt
Grampospath@grampospath.bsky.social · 8mo ago

The #StrepA upsurge of 2022/23 was dominated by emm1; the high mortality associated with emm1 is alarming. What is more alarming is that those who die, sadly die quickly esp children ; blaming any single person for a strep A death is not sensible. academic.oup.com/cid/advance-...

Mortality Among Patients With Invasive Group A Streptococcal Infections Caused by the M1UK Lineage: A Retrospective Cohort Study in England and Wales

Emm1 invasive Strep A incurs a high case fatality rate. In this national cohort, 24.4% of those with M1UK iGAS died, though this was not different from anc

academic.oup.com

Kimberly Kline 🏔@kimingeneva.bsky.social · 8mo ago

Excited to share our first look at Enterococcus faecium infection biology: diabetic wounds are complex, and E. faecium persists despite early immune responses. In diabetic mice, it shows impaired clearance + sustained neutrophil recruitment, worsening healing.

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 9mo ago

Enterococcus faecium colonization and persistence in a model of diabetic wound infection https://www.biorxiv.org/content/10.1101/2025.11.20.689639v1

Grampospath@grampospath.bsky.social · 10mo ago

ACFs in Infectious Diseases in London are now advertised including at Imperial /LSHTM /City St Georges /Kings. Open evening October 2nd about all our NIHR ACF/ACL programmes -details👇

Bild
Michael Marks@drmichaelmarks.bsky.social · 11mo ago

In early October we will be hosting an open evening on Academic Clinical Fellowships & Lectureships in Infectious Diseases across all the London programmes. These are integrated clinical academic training programmes for doctors training in the UK. You can sign up here: forms.gle/T867P8qQ2SMvvHhZ9

Grampospath@grampospath.bsky.social · last yr.

Points to a specific but I think meaningful immunity gap against two of the pathogens tested - strep A and RSV in 3-4 y olds. Age specific increment in anti Strep antibodies as you might hope. Just less in those post 2020. Preprint of interest to many of us in @ispylifenetwork.bsky.social

@tom-parks.bsky.social · last yr.

Why did invasive #strepA infections increase in young children after the pandemic? In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic: www.medrxiv.org/cgi/content/...

Grampospath@grampospath.bsky.social · last yr.

The actual list is here -the bbc list isn’t quite right www.gov.uk/government/p...

Priority pathogen families research and development tool

A reference tool to help guide England-based funders of research and development.

gov.uk

Connor G G Bamford@connorggbamford.bsky.social · last yr.

www.bbc.co.uk/news/article... a nice step forward but annoyingly inconsistent as some “pathogens” are species (eg Lassa) and others are whole orders of viruses (Flaviviridae). I think there’s better way to focus people. Interesting are those not on it though.

@nvansorge.bsky.social · last yr.

🔔🔔 🔔 Sound the alarm! Not 1 but 2 PhD positions available in my research group at Amsterdam UMC studying the interaction between S. aureus wall teichoic acids and the host immune system. Multidisciplinary projects with experience in academia and industry. werkenbij.amsterdamumc.org/en/vacatures...

Vacatures - PhD (x2) in Staphylococcus aureus immune interaction - Amsterdam UMC

Do you have ambition to be trained in broad, top-class scientific and professional skills and gain experience in industry and academia? Apply now!

werkenbij.amsterdamumc.org

Tiago Costa@tcostalab.bsky.social · last yr.

With @jrpenades.bsky.social, we challenged Google AI co-scientist to generate hypotheses. In just 2 days, it recapitulated our unpublished, experimentally confirmed mechanism for how cf-PICIs spread between bacterial species! @imperialcollegeldn.bsky.social tinyurl.com/3byyaeh2

AI mirrors experimental science to uncover a novel mechanism of gene transfer crucial to bacterial evolution

AI models have been proposed for hypothesis generation, but testing their ability to drive high-impact research is challenging, since an AI-generated hypothesis can take decades to validate. Here, we ...

tinyurl.com