Alex Keeley
@alexjkeeley.bsky.social
Wellcome Clinical PhD in Global Health @ MRC Gambia/LSHTM. ID SpR @Sheffield. Strep A Immuno-Epi and RHD. Climate, Social and Healthcare Justice. He/him
so just reading the title - I would say there is a lot more to this than amnesia
Gabriele Pollara@gpollara.bsky.social · last yr.Good title this: "Tuberculosis and the perils of historical amnesia" Good reminder about "...the enduring role of poverty, overcrowding, and substandard housing in sustaining tuberculosis in the present era.." #TBSky #IDSky @lancetmicrobe.bsky.social
A new study by @thushan-desilva.bsky.social @alexjkeeley.bsky.social & colleagues provides a framework for future Streptococcus pyogenes (Strep A) vaccine development by examining the natural acquisition of humoral immunity! www.nature.com/articles/s41... #Microbiology #Pathogen #VaccineDevelopment
Antibodies to conserved Streptococcus pyogenes antigens correlate with functional activity and protect Gambian children from culture‑confirmed infections, especially under age 2. by Keeley AJ, Camara FE (...) de Silva TI et 33 al. in Nat Med #MedSky 👉 get more here 📖 read the article:
Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting - Nature Medicine
Serological profiles from two observational cohort studies in The Gambia characterize surrogates of protection against Streptococcus pyogenes and reveal an antibody response against antigens that are currently in vaccine development.
nature.com
🧵 Our paper out today in @naturemedicine.bsky.social www.nature.com/articles/s41... On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon 1/ #Immunosky #IDsky #MicroSky #globalhealth.
nature.com
Beatriz Grinszetjn Opens #ias2025! While she can't provide a recipe for success in current climate, there are key factors 1. EVIDENCE 2. SOLIDARITY 3. TRUTH Let us make the most of our time together at the conference to "reaffirm, refocus & rebuild!" @iasociety.bsky.social
Prof de Silva & Dr Keeley speak on Strep A epi & immunity in the Gambia. 🗝️ Hyperendemicity of Strep A 🗝️ Index infections not explained by household contacts 🗝️ Early life immunity develops <2 y/o 🗝️ Ab response to carriage & infection 🗝️ ?protective immunity from SLO, SpyAD, SpyCEP #LISSSD25 #IDsky
This post just hits the nail on the head for me right now:
Tessa Hill@tessahill.bsky.social · last yr.There’s a real rearranging of the deck chairs on the Titanic vibe going on in academia right now.
#ESCMIDGlobal2025 threads: Buckets of cool research and breaded meats.... Not seen a single post on #PEPFAR / #USAID cuts. How do we stand together as a community to strongly condemn this tragedy, and work on solutions? If it's not our problem #ESCMID "global" NOW, then who? and when?
Great thread and paper: Where #StrepA burden greatest frequent lineage replacement seen. Interesting points: "vaccines without broad cross-lineage protection may also lead to S. pyogenes lineage replacement." "need to do better surveillance from carriage and non-invasive disease"
Steven Tong@steventong.bsky.social · 2y agoExploring epidemiology and lineage dynamics of invasive S. pyogenes across diverse regions of Australia. doi.org/10.1016/j.la.... Exciting new research published in @lancetmicrobe.bsky.social Posting on behalf of Ouli Xie (not on bsky) and our lab with Mark Davies. @thedohertyinst.bsky.social
★ NEW #Communicable out now! Today is Int'l Women's Day & to honour that we give you the first of a 2-part special on gender dynamics in medicine 🎙️ share.transistor.fm/s/21a9df96 #IDSky #clinmicro #IWD2025 @angelahuttner.bsky.social @erinmccreary.bsky.social @anniejoseph.bsky.social & more
Communicable E22: Women & men in medicine: An honest discussion, part 1 | Communicable | Episode 22
In honour of International Women's Day, Communicable releases the first of a two-part special on gender dynamics within the fields of infectious diseases and clinical microbiology. Moderated by Angela...
share.transistor.fm
Can any other funders step in to take this on? These platforms are invaluable and so much research and health security would be lost "with immediate effect" Hard (and almost feels inappropriate/pointless) to focus on thesis writing right now #globalhealth #IDSky
Madhu Pai, MD, PhD@madhupai.bsky.social · 2y agoThe sheer stupidity of this Trump administration is breathtaking DHS “terminated for the convenience of the U.S. Government” www.nytimes.com/2025/02/26/h...
10 years ago, when I began teaching global health, my courses were mostly the 'blue pill' version Slowly but surely, it has become reddish Every year brings more improvement & reflection @shashikalb.bsky.social & @ananyatb.bsky.social have been great co-teachers journals.plos.org/globalpublic...
Early life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high burden setting https://www.medrxiv.org/content/10.1101/2025.02.11.25322090v1
📢 Preprint - not peer-reviewed🤞: Development of #immunity to #StrepA in The Gambia. We assessed IgG to conserved and M protein antigens across the life course, exploring association with protection against infection: www.medrxiv.org/content/10.1... #IDSky #Immunosky
Early life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high burden setting
Streptococcus pyogenes leads to 500,000 deaths annually; many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to S. pyogenes hinders vaccine...
medrxiv.org
Excited to say that in collaboration with colleagues in Australia @latrobeuni.bsky.social we got NHMRC funding to use SpyCATS cohort to build state of the art #StrepA transmission models. Hope to ultimately better understand household transmission & help target interventions in high burden settings.
Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study
S pyogenes carriage and infection are common in The Gambia, particularly in children. Most events are non-household acquisitions, but skin carriage and pyoderma have an important role in S pyogenes household transmission and bidirectional transmission between skin and pharynx occurs.
thelancet.com
Great thread 👇 & 📜: A beautifully told story from complex serological data around @joshosowicki.bsky.social #StrepA human challenge. Amazing how much you can learn from controlled experimental challenge with 25 humans, setting standards for future CHIM / vaccine trials / seroepi ... #IDSky
Dr Danika Hill@precisionvaxlab.bsky.social · 2y ago🎉 I'm a #newPI , and I'm so excited to share our new paper out in Nature Comms today! 🧵 rdcu.be/d2gBV Quick intro for the new followers: I'm from Monash Uni in Melbourne, and we study T and B cell responses to viruses, bacteria & parasites with the goal of improving vaccines. #ImmunoSky #MicroSky
Here's something I missed on #IDTwitter last year: www.nejm.org/doi/full/10.... Phase 3 trial of NmCV-5 (ACWYX) meningitis vaccine in 2-29yo. Randomized, double-blind, noninferiority study vs. quadrivalent MenACWY-D for immunogenicity/safety over 28 days. #IDSky - recreating the space we lost
Meningococcal ACWYX Conjugate Vaccine in 2-to-29-Year-Olds in Mali and Gambia | NEJM
An effective, affordable, multivalent meningococcal conjugate vaccine is needed to prevent epidemic meningitis in the African meningitis belt. Data on the safety and immunogenicity of NmCV-5, a pen...
nejm.org
New research article in The Lancet Microbe #Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study www.thelancet.com/journals/lan... #StrepA #MicroSky #IDSky #OpenAccess #OA
www.tandfonline.com/doi/full/10....
The intricate pathogenicity of Group A Streptococcus: A comprehensive update
Group A Streptococcus (GAS) is a versatile pathogen that targets human lymphoid, decidual, skin, and soft tissues. Recent advancements have shed light on its airborne transmission, lymphatic spread...
tandfonline.com
www.thelancet.com/journals/lan... @madhupai.bsky.social @shashikalb.bsky.social @CKyobutungic A must read: summary on barriers (politics/funders/institutions/culture) to redressing global health power imbalances. But.. “power concedes nothing without a demand. It never did and it never will.”
Shifting power in global health will require leadership by the Global South and allyship by the Global North
Global health continues to be a field where Global North actors see themselves as leaders.1,2 Although the decolonising global health movement has exposed the deep inequities inherent within the architecture of global health,1 this movement, prone to elite capture, faces several institutional barriers that prevent meaningful shifts in power.3
thelancet.com
World feels pretty overwhelming right now... So please consider supporting: DEC donation.dec.org.uk/middle-east-... MSF msf.org.uk/secure/donate ..and this initiative by @madhupai.bsky.social: crowdfunding.mcgill.ca/ui/main/p/pa... to recognise those striving for equity in health.
crowdfunding.mcgill.ca
Starkly putting out tensions between conferences & carbon footprints Worked example for @escmid.bsky.social confernce but it's generalisable Benefits of in-person meetings are at environmental cost not easily squared #IDSky 🩺 #AcademicSky www.clinicalmicrobiologyandinfection.com/article/S119...
100% - So challenging to quantify the benefits of the irreplaceable interactions, (whereas the harms can be quantified - www.nature.com/articles/s41...) but we must proactively consider this, given our collective goal to reduce ill-health/suffering. Can to share my own frame work if anyone via DM
Quantifying the human cost of global warming - Nature Sustainability
As an alternative to monetary estimates, this study expresses the costs of climate change in terms of numbers of people left outside the ‘human climate niche’, which reflects the historically highly c...
nature.com
Gabriele Pollara@gpollara.bsky.social · 2y agoStarkly putting out tensions between conferences & carbon footprints Worked example for @escmid.bsky.social confernce but it's generalisable Benefits of in-person meetings are at environmental cost not easily squared #IDSky 🩺 #AcademicSky www.clinicalmicrobiologyandinfection.com/article/S119...
Dear IDTwitter refugees I made an #IDSky starter pack which makes it easy to find accounts of ID clinicians, medical microbiologists, ID researchers, ID epidemiologists, ID focused reporters, and of course journals ahead of the curve. Let me know if I missed you! go.bsky.app/LnAQjdq
patrick star from spongebob squarepants is standing on a sandy beach next to a black line .
ALT: patrick star from spongebob squarepants is standing on a sandy beach next to a black line .
media.tenor.com
BALANCE is an RCT of 3,608 pts with bloodstream infections randomized to 7 vs 14 days antibiotics Excl: Staph aureus, S lugdunensis, fungi, deep seated infections, severe immunocompromise No dif in 90d mortality or relapse Firmly establishes 7d as SOC #IDSky www.idsociety.org/news--public...
Antibiotic Treatment Regimen for Bloodstream Infections Can Safely Be Cut by Half
idsociety.org
A case of babesiosis acquired in the UK Increased prevalence of Babesia divergens in Ixodes ticks .... jumped to a human in this instance. #IDSky #MedSky #MicroSky wwwnc.cdc.gov/eid/article/...
Autochthonous Human <em>Babesia divergens</em> Infection, England
Human <em>B. divergens</em> Infection, England
wwwnc.cdc.gov
