Enkephalin Treatment Reduces Elevated Brain Glia in Mice With Experimental Autoimmune Encephalomyelitis

Background: Multiple sclerosis (MS) is a chronic, autoimmune disorder that culminates in severe motor and cognitive deficits. The progression of the disease is associated with inflammation and demyelination of the brain and spinal cord. Activation and proliferation of glia, including astrocytes a...

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Virtual Reality Versus Mental Practice On Balance And Gait In Patients With Multiple Sclerosis

This study is conducted to: * Investigate the effect of virtual reality based training on balance and risk of falling. * Investigate the effect of virtual reality based training on gait. * Investigate the effect of mental practice on balance and risk of falling. * Investigate ...

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Physical Exercise in Alzheimer's Disease: Impact on Functional Biomarkers and the Muscle-Gut-Brain Axis

Alzheimer's disease (AD) is the leading cause of dementia worldwide and involves systemic alterations beyond the brain, such as loss of muscle strength, chronic low-grade inflammation, and gut microbiome dysbiosis. Physical exercise is a promising non-pharmacological therapy, ...

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Targeting P2Y12 limits TH17 accumulation in the CNS and reduces EAE progression

Platelets are increasingly recognized as active amplifiers of neuroinflammation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). P2Y12 is an essential ADP receptor that regulates platelet activation and is upregulated in neuroinflammatory lesions. However, its contributi...

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Mechanistic Biomarkers of Music-Induced Analgesia in Early-Stage ADRD

Chronic pain is common among people living with Alzheimer's disease and related dementias (ADRD) and can negatively affect daily functioning and quality of life. Music listening may help manage pain, but researchers do not fully understand how music influences brain activity a...

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Chinese University-Alzheimer's Disease With Vascular and Other Co-pathology: Towards Actionable Neuro-Cognitive-Omic Evaluations (CU-ADVANCE)

Population aging is transforming the epidemiological landscape of the Asia-Pacific region at an unprecedented pace. By 2050, more than one quarter of the region's population will be aged over 60, with 36.7% of countries projected to become" super-aged" societies. Within Hong K...

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Treatment of Memory Retrieval Impairments in MS With HDtDCS to the LIFG in a Placebo Controlled Trial

The purpose of the study is to test whether low-level electric stimulation, called High Definition transcranial Direct Current Stimulation (HDtDCS), on the part of the brain (i.e., left inferior frontal gyrus) thought to aid in memory will improve verbal retrieval in multiple ...

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Sviluppo, Validazione e Dati Normativi Della Batteria Italiana Per il Riconoscimento Dei Volti Famosi I-FACE

The I-FACE project aims to develop and validate a battery to assess famous-face recognition in people with neurodegenerative diseases and stroke. It will examine face naming, familiarity, and semantic knowledge, establish norms for the Italian population, and test how well the...

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Reelin-enhanced neural stem cell therapy promotes neuroangiogenesis, remyelination, and functional recovery after subcortical capsular ischemic stroke

Life Sci. 2026 Nov 3:124767. doi: 10.1016/j.lfs.2026.124767. Online ahead of print. ABSTRACT AIMS: This study established a reproducible mouse model of posterior limb of the internal capsule (PLIC) ischemia to investigate whether Reelin potentiates neural stem cell (NSC)-mediated functional and s...

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China HEalthy Aging and Dementia Study (HEAD)

The China HEalthy Aging and Dementia (HEAD) study is a large-scale, community-based, multi-center prospective cohort study covering eastern, northern, southern, and central-western regions of China. By integrating comprehensive clinical, neuroimaging, biospecimen, and multi-om...

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Targeting Sleep and Slow-Wave Activity to Enhance Cognition in MCI

Study Description As most clinical trials in Alzheimer's disease (AD) have been unsuccessful to date, it has become increasingly crucial to focus on treating earlier stages of the disease. Compelling evidence indicates that sleep disruption is associated with accumulation of A...

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BioMIND Repository for the Collection and Storage of Biospecimens From Individuals With Memory Concerns

The purpose of the BBR is to facilitate scientific research by serving as a local and external resource for the distribution of human blood and CSF biospecimens, together with their corresponding clinical data, to internal and external researchers.

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A Biosimilar Trial to Investigate PK, PD, and Safety with PB018 versus US-licensed Ocrevus® and EU-approved Ocrevus®

Trial number : 2026-525314-61-00 Overall trial status : Authorised, recruitment pending Trial title : A Biosimilar Trial to Investigate PK, PD, and Safety with PB018 versus US-licensed Ocrevus® and EU-approved Ocrevus® Medical conditions : Multiple sclerosis Status in each c...

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Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Multiple sclerosis destroys myelin and, over time, nerve cells. The spinal cord and brain contain immature progenitor cells that could replace both, and their…

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Targeting TLR4 alleviates the progression of experimental autoimmune encephalomyelitis by regulating central resident cells and Th1/Th17 cell differentiation

Multiple sclerosis (MS) is an autoimmune demyelinating disease characterized by neuroinflammation. Toll-like receptor 4 (TLR4) is a receptor for damage-associated molecular patterns, such as high-mobility group box 1 (HMGB1) and plays a role in innate immunity. However, its precise role and cellu...

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Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we sho...

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Comprehensive Analysis of the Immune and Stromal Compartments of the CNS in EAE Mice Reveal Pathways by Which Chloroquine Suppresses Neuroinflammation

Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) are neuroinflammatory diseases of the central nervous system (CNS), where leukocytes and CNS resident cells play important roles in disease development and pathogenesis. The antimalarial drug chloroquine (CQ) has been sho...

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Effect of Electrical Stimulation on Remyelination in Preclinical Models of Multiple Sclerosis: A Systematic Review

Prog Neurobiol. 2026 Oct 30:102967. doi: 10.1016/j.pneurobio.2026.102967. Online ahead of print. ABSTRACT BACKGROUND: Different types of electrical stimulations (ES), transcranial direct current stimulation (tDCS), vagus nerve stimulation (VNS), and peripheral nerve stimulation (PNS) have emerged...

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A Phase 3 extension study to investigate long-term safety and tolerability of frexalimab in participants with multiple sclerosis.

Trial number : 2026-525688-41-00 Overall trial status : Authorised, recruitment pending Trial title : A Phase 3 extension study to investigate long-term safety and tolerability of frexalimab in participants with multiple sclerosis. Medical conditions : multiple sclerosis Statu...

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Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

ABSTRACT Neurodegenerative diseases, including multiple sclerosis (MS), are characterized by progressive neuronal loss and limited regenerative capacity. To stimulate in vivo neurogenesis and oligodendrogenesis by harnessing the untapped regenerative potential of endogenous neural progenitor cell...

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Smart nanocarriers and biomaterials for targeted drug delivery in spinal cord injury: molecular mechanisms and translational perspectives

Spinal cord injury (SCI) results in permanent motor, sensory, and autonomic dysfunction below the level of injury; currently, there are no effective treatments to promote neural functional recovery. Inflammatory responses, oxidative stress, apoptosis, excitotoxicity, glial scarring, and impaired ...

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Analisi Automatizzata Del Linguaggio Nelle Malattie Neurodegenerative: Applicazione di Modelli di Intelligenza Artificiale

This multicenter study aims to characterize the language profiles of patients with various neurodegenerative diseases, including Alzheimer's disease (AD), Primary Progressive Aphasia (PPA), behavioral variant Frontotemporal Dementia (bvFTD), Dementia with Lewy Bodies (DLB), an...

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Prospective in Vivo Ultra-high-performance PET Imaging of Synaptic Density, Reactive Astrogliosis and Tau Accumulation in Alzheimer's Disease, Healthy Controls and Centenarians and Relationship With Fluid Biomarkers

AIM: to investigate the relationship between synaptic density, tau and reactive astrogliosis in Alzheimer's disease (AD) versus healthy controls and centenarians. DESIGN: this cross-sectional study will recruit patients with biomarker-proven AD, age- and sex-matched healthy co...

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Efficacy and tolerability of metformin as an adjuvant therapy in patients with relapse-remitting multiple sclerosis receiving interferon Beta 1a: A randomized pilot trial

Background Neurodegeneration and inflammation can accelerate the demyelination process in multiple sclerosis (MS). We aimed to investigate the efficacy and tolerability of metformin as an add-on treatment to interferon Beta 1a (IFNβ-1a) in Egyptian patients with relapsing-remitting multiple scle...

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A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Study to Evaluate the Efficacy and Safety of Simenafil Hydrochloride Tablets in the Treatment of Alzheimer's Disease

This study is a multicenter, randomized, double-Blind, placebo-controlled Phase 2 clinical study to evaluate the efficacy and safety of Simenafil Hydrochloride Tablets in the treatment of participants with Alzheimer's Disease

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Neurogenetics and Multi-omics of Neuroinflammatory Diseases in Multiplex Families to Improve Patients Health

The goal of this observational study is to learn why some families have several members with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), or MOG antibody-associated disease (MOGAD). These diseases happen when the immune system attacks the brain, opt...

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Teriflunomide ameliorates inflammatory diseases via direct inhibition of the NLRP3 inflammasome

Although the NLRP3 inflammasome drives numerous inflammatory diseases, clinically approved targeted inhibitors remain lacking. Here, we reveal that teriflunomide (Teri), an approved multiple sclerosis (MS) drug conventionally thought to act via dihydroorotate dehydrogenase (DHODH) inhibition, ame...

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Real-World Effectiveness and Safety of Autologous Haematopoietic Stem Cell Transplantation and Other Therapeutic Strategies in Multiple Sclerosis (REAL-MS) - An Observational Database Study

Multiple sclerosis (MS) is a condition in which the immune system damages the brain and spinal cord. Treatments called disease-modifying therapies can reduce inflammation and disease activity. For some people with highly active MS, autologous haematopoietic stem cell transplan...

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EXO-MS: Effect of the EXOPULSE Suit on Mobility, Walking, and Balance in Multiple Sclerosis: A Double-Blind, Controlled, Parallel-Group Trial

This clinical research study is investigating whether the EXOPULSE Suit, a wearable device that delivers electrical stimulation, can help improve movement difficulties caused by spasticity in adults with multiple sclerosis (MS). The main goal of the study is to evaluate the ef...

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