1/n Check out our new paper, spearheaded by @fborne.bsky.social, just out in PLoS Genetics doi.org/10.1371/jour....

Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein

Author summary Proteins fold into three-dimensional structures that are essential for their function. Because these structures depend on interactions among amino acids, the fitness effect of a mutatio...

doi.org

BREAKING: New proposed OMB regulation, applying to all federal grants, requiring grant reviews by senior political appointees and re-emphasizes that "peer review remains advisory and does not replace agency discretion". #standupforscience public-inspection.federalregister.gov/2026-10817.pdf

More than two-thirds of the papers we've published since the lab started in 2019 have international co-authors, who have greatly enriched the science that we do bsky.app/profile/jros...

Jeffrey Ross-Ibarra@jrossibarra.bsky.social · 2mo ago

So no publication fees, no conferences, no international collab, and we can terminate or reject your grant anytime for any reason. This might have some impact on how science works, folks. And maybe just maybe not a positive one.

I'm excited to share that our work studying gene dosage response curves (GDRCs) is now out in Cell Genomics (@cellpress.bsky.social). www.cell.com/cell-genomic... [1/n]

Buffering of gene dosage response curves for human complex traits

Milind et al. explore why loss-of-function variants and duplications tend to have average effects in the same direction on 94 complex traits. Using gene dosage response curves (GDRCs), they gather evi...

cell.com

Happy to have the chance to share this commentary by @will-milligan.bsky.social & me: rdcu.be/fldBs.

Delighted to share our latest preprint: Julie Zhu identifies a surprising reason why the genetic architecture of brain-related traits is so different than other traits. Check it out!

Huisheng (Julie) Zhu@huishengzhu.bsky.social · 4mo ago

Why do schizophrenia GWAS signals look so flat across the genome? In our recent preprint, we explored why psychiatric disorders — and, more broadly, brain-related traits involving the central nervous system — appear to have unusual genetic architectures. 🧵1/n

My lab read this paper www.biorxiv.org/content/10.1... for journal club, and had some thoughts on the strong claims made about the number of signals of selection found.

Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

For an update on our preprint about the mysterious signature SBS5, see: www.biorxiv.org/content/10.1.... New analyses throughout, but see Figure 5 in particular.

Molly Przeworski@mollyprz.bsky.social · 11mo ago

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...

The program for the 2026 New York Population Genetics meeting, hosted by at the @simonsfoundation.org on March 9th 2026, is now up: events.simonsfoundation.org/event/7c91dd....

Congratulations Jeff! It's been really wonderful to have you in the lab! I cannot wait to see all the fantastic work that will come out of your future lab. ...and trainees, Jeff is an amazing scientist and mentor! If you ever have a chance to work with him you should seize it with both hands!

Jeff Spence@jeffspence.github.io · last yr.

I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July. We'll work at the intersection of statistical genetics, population genetics, and machine learning.

“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...

The distribution of highly deleterious variants across human ancestry groups

A major focus of human genetics is to map severe disease mutations. Increasingly that goal is understood as requiring huge numbers of people to be sequenced from every broadly-defined genetic ancestry...

biorxiv.org