gsbardella.bsky.social
@gsbardella.bsky.social
Medicinal Chemist/Chemical Biologist; Professor at the University of Salerno; epigenetics; EFMC EC Secretary; ChemMedChem EB Chair; cooking, food, and wine lover; opinions are my own ORCID: orcid.org/0000-0003-0748-1145
Follow up to Doug Hanahan’s visionary article about the stages of cancer development from back in the 1990s www.cell.com/cell/fulltex...
Hallmarks of cancer—Then and now, and beyond
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...
cell.com
As 2025 ends, we sincerely thank you for your trust and support of EFMC. Wishing you a joyful festive season and a prosperous New Year! Warm regards, Luc Van Hijfte (EFMC President) Gianluca Sbardella (EFMC President Elect)
The #AvogadroColloquia 2025 ended in the best possible way, with an amazing, truly inspiring talk by @francesarnold.bsky.social. A great honor for the Italian chemical community (@socchimita.bsky.social and CNR) and an unforgettable memory for the attendees.
Join @youngscinet.bsky.social for "Under Pressure: A Mental Health Conversation for the Academic Community," a virtual workshop aimed at building resilience, support and creating a healthier future for yourself and academia. October 10 - 1PM 🔗 us06web.zoom.us/webinar/regi...
👩🔬 Have you read our latest #MedChemBioConversation ? Get to know Maria Letizia Barreca from University of Perugia, Italy.🔍 Dive into our monthly talks with specialists to explore the latest breakthroughs in drug discovery and pick up some valuable advice. 🔗https://buff.ly/63Jy5As
The report of the FiMC, co-organized by the Med Chem Division of the @gdch.de, the #DPhG and the @scs-dmccb.bsky.social, has been just published in #ChemMedChem (@chemistryeurope.bsky.social) chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
A Warm Welcome to MedChem: The Frontiers in Medicinal Chemistry 2025
The Frontiers in Medicinal Chemistry (FiMC) is the largest international Medicinal Chemistry conference in Germany and took place from April 1st to 4th, 2025, in Erlangen. This conference report summ...
chemistry-europe.onlinelibrary.wiley.com
SwissMedChemBio@scs-dmccb.bsky.social · 11mo agoDo you want to learn more about conferences that we co-organize outside of Switzerland? The report of the FiMC, co-organized by the @swisschemistry.bsky.social 🇨🇭and @gdch.de 🇩🇪, was just published in ChemMedChem 🧫🧪 chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
A new #ChemMedChem (@chemistryeurope.bsky.social) article explores the effect of modified bifunctional antisense oligonucleotides (BASOs) on the phenotype of cancer cells, evaluated by real-time measurement of cell proliferation and motility. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Modified Nucleotides in Bifunctional Antisense Oligonucleotides: Exploring their Anticancer Potential
bifunctional antisense oligonucleotide (BASO) modulates pre-mRNA splicing by using two functional domains: an antisense region that hybridizes with target sequences and a regulatory region that recru...
chemistry-europe.onlinelibrary.wiley.com
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...) with a Front Cover illustrating the crystal structure of the N-terminal domain of clathrin with the known binding sites colored and a selection of Pitstop 2 analogues.
An Highlight article just accepted in #ChemMedChem (@chemistryeurope.bsky.social) spotlights #balinatunfib, an orally available small molecule jointly developed by Sanofi and UCB preventing TNFα from effectively binding to its receptors. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
I have poked the @rsc.org on X/Twitter a bit over the years (sorry folks...), but huge kudos to them for leaving what has become even more of a toxic and hateful platform www.rsc.org/news-events/... 👏 #chemsky
Social media and connecting with our community
rsc.org
Only two weeks left to apply for a Flash Talk at the 5th Virtual @chembiotalks.bsky.social! If you are a PhD or postdoc and want a chance to present to a global #ChemBio audience, make sure to check out our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
Another great edition of @youngscinet.bsky.social #MedChemBioOnline is going to start in 1 hour and a half. Do not miss the opportunity to learn about "Best Practices in Discovering PROTACs" with experts in the field!
EFMC Young Scientists Network@youngscinet.bsky.social · last yr.Swipe to discover our speakers! Join us in 2 weeks for the 21st EFMC-YSN MedChemBioOnline on June 17, 2025, from 15:30 to 17:30 CET. Learn about “Best Practices in Discovering PROTACs” with experts. 💻 Online via Zoom 🔗 Free, but registration is mandatory Thanks to our sponsor Advion.
The last talk of the day at the 11th Novalix Conference “Biophysics in Drug Discovery” was the terrific keynote lecture by Stefan Knapp on "Comprehensive Characterization of Chemical Tools and New Modalities such as PROTACs". @thesgc.bsky.social
Amazing keynote lecture by Amanda Garner at the 11th Novalix Conference—Biophysics in Drug Discovery in Strasbourg. Amanda delivered a brilliant talk on "Enabling Technologies for Revealing Druggable Paths in RNA Biology". @acsmedi.bsky.social
Great talk by @mariaduca-cnrs.bsky.social at the 11th Novalix Conference about Biophysics in Drug Discovery. Maria presented a few of her group projects, talking on how to target RNA using synthetic small molecules and how to discover an characterize RNA binders. Brilliant!
No orders for supplies/reagents/equipment (already a huge bottleneck after earlier cuts). No travel or conference registrations. And certainly no hiring. So this could be a total freeze, in everything but name. Is that the new workaround the administration is trying? Isn't that illegal? (2/2)
I'm getting word that the latest attempt to strangle what's left of the NIH is that purchasing agents have been mostly/completely cut, with the purchasing to be done by centralized GSA staff. Who either don't exist or aren't assigned. That means in practice no spending at all! (1/2)
If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules. cen.acs.org/acs-news/acs...
12 drug candidates debut in San Diego
Structures unveiled during first-time disclosures symposium
cen.acs.org
An amazing, totally inspirational and emotional journey! The @acs.org Priestley Medal talk by @francesarnold.bsky.social at #ACSSpring2025
The response of the science community to the last month is not about one statement or action. It's about all of us with our different frames. For Science's part, we are doing what we have always done and have no plans to change. My thoughts on what we can do. www.science.org/doi/10.1126/...
Come together, right now
The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...
science.org
New on @science.org's daily Trump Tracker: A key influenza vaccine meeting gets abruptly canceled, and more than 90% of all USAID grants are terminated. www.science.org/content/arti...
Trump Tracker: Firings, lawsuits, and U.S. science in chaos
Follow President Donald Trump’s impact on U.S. research and science globally
science.org
A new White House freeze on using government-issued credit cards is the latest shock for federal scientists, potentially affecting everything from conference travel to needed purchases for clinical care or lab work. scim.ag/4hV9oRb
Trump credit card freeze sparks alarm at health agencies
“Cost efficiency” order could block travel, supplies for labs and patient care
scim.ag
A Career doing STUFF, a Guest Editorial by Mike Hann for the #ChemMedChem (@chemistryeurope.bsky.social) MedChem Musings series, summarises the many things he did during his 45 year-career in drug discovery. Practical advices and inspiration for future generations of researchers. lnkd.in/dNNy7FaE
The Hit to Lead process is an integral part of contemporary drug discovery. A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead
Best practices for the Hit-to-Lead phase of drug discovery are exemplified in this article, with links to further materials and references as a learning resource. This consensus output was produced b....
chemistry-europe.onlinelibrary.wiley.com
This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
Understanding of how structural elements impact #atropisomer stability enables the more efficient optimization of this important feature. A new manuscript just accepted in #ChemMedChem (@chemistryeurope.bsky.social) chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
