From @c3genomics.bsky.social, the #Canadian Centre for #Computational #Genomics | Inside #GenPipes: Exploring C3G's Software Solution for Life Science Research | #CoreFacility #OpenScience #Bioinformatics #Education 🧬 🖥️ 🧪 ⬇️ computationalgenomics.ca/inside-genpi...

Inside GenPipes: Exploring C3G's Software Solution for Life Science Research - Canadian Centre for Computational Genomics

Take a closer look at one of C3G’s software solutions; its purpose, its strengths, its newest features, and how it continues to support the life science community.

computationalgenomics.ca

Exciting to see this out! Please take a look and let us know what you think about our new tool for STR genotyping.

David Lougheed@davidlougheed.bsky.social · 5mo ago

Work from my M.Sc. with @guilbourque.bsky.social is in this month's issue of Genome Research, detailing my short tandem repeat (STR) genotyping tool for long-read data! Article: genome.cshlp.org/content/36/3... STRkit: github.com/davidloughee...

Crushed to hear of Mark Batzer’s passing. He was the Boyd Professor at Louisiana State University. His influential research revealed how mobile elements shape the genomes of humans & other mammals. Mark’s personality, generosity & positivity were larger than life. He lifted everyone up. HUGE loss 💔

Nice Christmas gift to see it in print!

Mathieu Lupien@matlupien.bsky.social · 7mo ago

Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.

Exciting new conference!

ISCB News@iscb.bsky.social · 8mo ago

🔔 Don’t forget: Abstract submissions for #CBHC2026 are open! 🗓️ Deadline: Feb 12, 2026 📥 Submit here: https://f.mtr.cool/oftnlpqjlg

Congrats Manvendra, well deserved!

Manvendra Singh@manusingh.bsky.social · 8mo ago

#NewPI #Neuroscience #Immunology #Transposons #SciComm #HERVs Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.

GA4GH April Connect 2026 registration and session proposal submissions are now open! The meeting will take place from 14 to 17 April 2026 in Montreal, Canada. We invite the GA4GH community to submit session proposals by 30 January. Learn more: broadinstitute.swoogo.com/connect26/10...

Exciting! Glad to see the Gold Cohort starting to get used for new discoveries!

Marathon of Hope Cancer Centres Network@marathonofhope.bsky.social · 9mo ago

🧬 🌐 Uncovering cancer’s hidden driver mutations through the power of the Gold Cohort 🧬 🌐 A research team led by Dr. Ian Watson will harness the power of MOHCCN's Gold Cohort to identify new mutations that may be responsible for driving cancer. tinyurl.com/5n7c6ub8

Excited to share our preprint on the “Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer” led by @lynnkaram.bsky.social! www.biorxiv.org/content/10.1...

Such a great @ga4gh.org meeting in Uppsala this past week. Genomics, with the help of GA4GH standards and policies, is really moving into the Age of Implementation globally!

If you’re planning to be at ASHG, you should go see the poster ⬇️

Yuxin Zhou@yuxinzhou.bsky.social · 10mo ago

Thanks for sharing our work, @guilbourque.bsky.social! This work will also be presented at the #ASHG2025 conference on Wednesday, October 15th, in Boston!! My poster can be found at Board 1100W at the Thomas M. Menino Convention Center. Come and talk to me 🧬!!

Wow, great summary!

Ewan Birney@ewanbirney.bsky.social · 10mo ago

Some thoughts on the blossoming of genomic medicine stimulated by the excellent @ga4gh.org meeting in lovely Uppsala Sweden. www.linkedin.com/pulse/though...

Thanks for sharing our work, @guilbourque.bsky.social! This work will also be presented at the #ASHG2025 conference on Wednesday, October 15th, in Boston!! My poster can be found at Board 1100W at the Thomas M. Menino Convention Center. Come and talk to me 🧬!!

Guillaume Bourque@guilbourque.bsky.social · 10mo ago

🚨 New paper alert on telomeres! 🚨 Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.

🚨 New paper alert on telomeres! 🚨 Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.

So inspiring to run with Darryl Fox to support Terry’s dream and the @marathonofhope.bsky.social

Looks like my book is available for pre-order: a.co/d/cTKIwBN #EpigeneticsBook

Excited for the start of the Croucher Retrotransposons meeting organized by Danny Leung in Hong Kong. First speaker, the King of Krabs! projects.croucher.org.hk/advanced-stu...

The issue that jumped at us in the current annotation of young LTR subfamilies in human, is that there was lot of variability in divergence rate (sometimes bimodal). That's what we tried to improve.

Guillaume Bourque@guilbourque.bsky.social · last yr.

Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...

Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...

A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage

A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.

science.org

Lentivirus massively parallel reporter assays integrate & enrich for specific sequences in the genome. We utilize this to test their epigenetic modifications & open chromatin alongside their regulatory activity. Amazing work by Zicong Zhang, Fumitaka Inoue & others. www.biorxiv.org/content/10.1...

Simultaneous epigenomic profiling and regulatory activity measurement using e2MPRA

Cis-regulatory elements (CREs) have a major effect on phenotypes including disease. They are identified in a genome-wide manner by analyzing the binding of transcription factors (TFs), various co-fact...

biorxiv.org

The human pangenome continues to grow and improve! Release 2 is here! Click through for the details, but this is a pretty amazing dataset including not just the phased assemblies, but PacBio HiFi, ONT Ultralong, Dovetail/Illumina Hi-C, PacBio Kinnex, and Illumina WGS for all samples

Human Pangenome Reference Consortium@humanpangenome.bsky.social · last yr.

📢 HPRC Release 2 is here! Now with phased genomes from 200+ individuals, a 5x increase from Release 1. Explore sequencing data, assemblies, annotations & alignments in our interactive data explorer ⬇️: humanpangenome.org/hprc-data-re...

Canada’s genomics community is rising to the challenge. ➡️ We’re sequencing 100K human genomes in 4 years to give researchers and innovators the data they need to transform health care. Learn how the diversity of the dataset we build will set Canada apart as a global leader in #PrecisionHealth.

The Conversation Canada@ca.theconversation.com · last yr.

A golden era for personalized medicine is approaching, but are we ready?

Excellent opportunity for PI positions at the Genome Institute of Singapore! Outstanding facilities, latest genomic technologies, strong and stable science funding. Junior candidates and established scientists are welcome to apply

A*STAR Genome Institute of Singapore (A*STAR GIS)@astar-gis.bsky.social · last yr.

Are you passionate about advancing scientific research?🧬🔬 🧪 We are #hiring Principal Investigators who are ready to make a difference in the world of genomic research in AI, Computational biology to develop novel high throughput technologies for unveiling new insights into the biology of DNA or RNA!

Bye bye magical Kyoto, see you next time!

Check out the new STR tool from @davidlougheed.bsky.social in the group! Works with both PacBio and Nanopore!

David Lougheed@davidlougheed.bsky.social · last yr.

I’m happy to (finally!) share STRkit, a short tandem repeat genotyping tool for long reads that I've developed in @guilbourque.bsky.social's group over the past few years. Here we describe STRkit & demonstrate state-of-the-art performance in some benchmarks – long reads are great for resolving STRs!

#GoCanadaGo

Yeah, great one!

Quaid Morris@quaidmorris.bsky.social · last yr.

Errands for RNA!

On January 6th, 1995, my (now ex) wife and I boarded a flight from Heathrow to JFK on a one way ticket. We had two suitcases and about $900 in cash - this was everything we owned and we were moving to the US. We thought it was maybe for 2-3 years. I had visited the US once, for a conference, and

We are recruiting! We have an open position for a postdoctoral fellow to join our team at the Genome Institute of Singapore to work with long read RNA-Seq data. It’s a beautiful city state and outstanding research environment! More details here: jglab.org/postdoc-posi...

Amazing! So moving. Such an important cause.

Jim Woodgett@jwoodgett.bsky.social · last yr.

Two remarkable and iconic Canadians who brought Canada together, #TerryFox and #GordDownie of the #TragicallyHip. An anthem of our time. Cancer: Finish It.