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Cedric Feschotte

@cedricfeschotte.bsky.social

Prof at Cornell, #firstgen, immigrant 🇫🇷🇺🇸. Transposons, viruses, and all the cool stuff genomes are made of. https://www.feschottelab.com

235 Posts1328 Follower420 Folgt
Cedric Feschotte@cedricfeschotte.bsky.social · 3w ago

Super proud and excited about this work, led masterfully by Peiwei Chen! A fun and fruitful collaboration with department colleagues Andy Clark & Alexei Aravin. After 30 yrs of studying transposons, this is one of the very first times I see them jump in real time in their natural host! Hurrah! 🥳

Peiwei Chen@peiwei-chen.bsky.social · 4w ago

How do transposons jump when they’re released from host control? I babysat two chromosomes for 2 years, making sure they are ok without most piRNAs. Here’s what we found & excited to share my 1st postdoc paper: “piRNA loss unleashes episodic transposition bursts” www.biorxiv.org/content/10.6...

Cedric Feschotte@cedricfeschotte.bsky.social · last mo.

📣 Abstract submission deadline for CSHL TEs extended to July 24! Two more weeks to submit your abstract for a short talk or poster — do it! It’s gonna be a fantastic meeting!! meetings.cshl.edu/meetings.asp...

Transposable Elements

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

Cedric Feschotte@cedricfeschotte.bsky.social · 3mo ago

👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp...

Daniel Croll@danielcroll.bsky.social · 2mo ago

🔔 Our synthesis on what’s going on in the field of TE control and RIP in the fungal world! Out now in Trends in Genetics!

Thomas Badet@tbadet.bsky.social · 2mo ago

Nearly a year after our symposium on Repeat-Induced Point (RIP) mutations, I’m happy to share the fruit of some of our discussions. The fungal RIP hypermutator mechanism has deep eukaryotic roots www.sciencedirect.com/science/arti... We hope to spark interest in this underappreciated mechanism.

Evolution of major eukaryotic genome defense systems. The figure is organized along two axes representing core mechanistic features (homology recognition, small interfering RNA, and heterochromatin assembly) and their lineage-specific elaborations. We hypothesize that a recombination-independent DNA homology recognition system present in the eukaryotic common ancestor facilitated the emergence of both heterochromatin assembly and small RNA-based repeat silencing. From this conserved ancestral core, lineage-specific gene neofunctionalizations gave rise to distinct defense pathways: the RdDM pathway in plants; the piRNA and KRAB–ZFP pathways in vertebrates; and the repeat-induced point mutation (RIP), methylation induced premeiotically (MIP), MSUD, and tandem repeat-induced sexual silencing (TRISS) systems in filamentous ascomycete fungi. Question marks indicate steps for which the molecular mechanisms remain unknown.
Matthew Taliaferro@jmtali.bsky.social · 2mo ago

New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵

Etienne Bucher 🌾🧬🇪🇺@plantepigenetics.ch · 2mo ago

We just published our new paper about an active Helitron transposon in wheat 🌾🧬 We found that it can be mobilised by heat stress when DNA methylation is reduced. We document its full lifecycle: RNA -> circular DNA -> integration www.nature.com/articles/s41... #TEsky

An active Helitron transposon family in wheat - Nature Plants

Helitrons are a recently identified category of transposons. This study reveals that heat stress combined with reduced DNA methylation can mobilize a Helitron family in wheat. Its mobilization is gene...

nature.com

Molly Przeworski@mollyprz.bsky.social · 2mo ago

Now published: journals.plos.org/plosbiology/...

What sets the mutation rate of a cell type in an animal species?

Mutation rates per generation are strikingly similar across germlines of animals and across at least one somatic cell type, suggesting a key role for natural selection in shaping mutation rates. This ...

journals.plos.org

Molly Przeworski@mollyprz.bsky.social · 8mo ago

Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

Stanford AAUP@stanfordaaup.bsky.social · 2mo ago

Want more breakthroughs like this? Fight like mad to keep the changes to OMB's Federal Financial Assistance Rule from being enacted! www.federalregister.gov/public-inspe...

Regulation for Federal Financial Assistance

The Office of Management and Budget (OMB) proposes to revise the Guidance for Federal Financial Assistance to improve government- wide policies and requirements related to the management of grants, co...

federalregister.gov

Dr. Lucky Tran@luckytran.com · 2mo ago

Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)

Alex de Mendoza@alexdemendoza.bsky.social · 2mo ago

Capolavoro 🎨 alert 🚨! What is the role of gene body methylation in invertebrates? Despite extensive speculation linking it to plasticity and environmental responses, its mechanistic effects and heritability remain unclear. Our take out in @natecoevo.nature.com: www.nature.com/articles/s41... 1/

Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian - Nature Ecology & Evolution

Experiments in the cnidarian Nematostella vectensis show a role of gene body methylation in transposable element suppression and that epigenetic inheritance is constrained by chromatin context and tra...

nature.com

Cedric Feschotte@cedricfeschotte.bsky.social · 3mo ago

Wrote a short piece on Transposable Elements as catalysts of evolutionary innovation for a forthcoming special issue of @naturerevgenet.bsky.social on, duh, Evolutionary Innovation! www.nature.com/articles/s41...

Transposable elements as catalysts of evolutionary innovation - Nature Reviews Genetics

In this Comment, Cedric Feschotte highlights evidence from diverse lineages showing that transposable elements are key drivers of evolutionary innovation, repeatedly introducing regulatory and coding ...

nature.com

Needhi Bhalla 💅🏽@needhibhalla.bsky.social · 3mo ago

👀"These results establish that naturally occurring copy-number variation within repetitive pericentromeric DNA is not merely noise, but a functional source of variation in chromosome segregation and gene regulation."

bioRxiv Genetics@biorxiv-genetic.bsky.social · 3mo ago

Pericentromeric repeat copy number tunes heterochromatin dosage to control chromosome segregation and gene expression in fission yeast https://www.biorxiv.org/content/10.64898/2026.05.08.723760v1

Peiwei Chen@peiwei-chen.bsky.social · 4mo ago

plz repost 🙏 we are looking for a technician to start this summer/fall for 1-2 years to work with me at Cornell in the labs of @cedricfeschotte.bsky.social and Andy Clark, in collaboration with @corriemoreau.bsky.social on flies & termites 🪰🐜🧬🔬 Ithaca is gorges! jobs.hr.cornell.edu/us/en/job/WD...

CALS- Technician I- Molecular Biology and Genetics in Ithaca, New York, United States of America | Research & Instructional Support at Cornell University

Apply for CALS- Technician I- Molecular Biology and Genetics job with Cornell University in Ithaca, New York, United States of America. Research & Instructional Support at Cornell University

jobs.hr.cornell.edu