Happy to share our latest #preprint that reveals the #new role of how Mtb's adenylate cyclase switch acts as the foundation for its distinct physiology during conditional adaptation. Kudos to the team @nitinbaliga.bsky.social and @isbscience.org 🎉

bioRxiv SysBio@biorxiv-sysbio.bsky.social · 2w ago

An adenylyl cyclase switch reroutes carbon from growth to virulence lipids in Mycobacterium tuberculosis https://www.biorxiv.org/content/10.64898/2026.09.10.750769v1

If you missed this week’s Research Roundtable, the recording is now available. ISB’s @alicekane.bsky.social explores the biology of aging — including frailty, menopause, and what shapes long-term health. Watch here: isbscience.org/news/isb-eve...

How the Body Ages: Exploring Frailty, Menopause, and the Biology of Healthspan

Alice Kane on aging, frailty, and healthspan, highlighting new biomarkers, sex differences, and insights into menopause and women’s health.

isbscience.org

Our recent #CTSjournal paper on the initial public release of the Biomedical Data Translator was selected as Paper of the Month by @ascptclinpharm.bsky.social An open-source, knowledge graph–based reasoning system. www.linkedin.com/feed/update/... ascpt.onlinelibrary.wiley.com/doi/10.1111/... 🧪

Announcing the Biomedical Data Translator: Initial Public Release

The growing availability of biomedical data offers vast potential to improve human health, but the complexity and lack of integration of these datasets often limit their utility. To address this, the...

ascpt.onlinelibrary.wiley.com

Today I am starting a weekly post titled "Autism: The Evidence". I hope it helps someone fight the colossal wave of misinformation that is drowning us. Part 1: I heard Autism prevalence has gone up. Is that true? If so why?

Our MicrobiomeKG paper is finally fully published! A knowledge graph connecting microbes with host health. It's been a joy to mentor and work with Skye Goetz. This is her first paper as first author! Likewise, always great working with Amy Glen. 🧪 www.frontiersin.org/journals/sys...

We had a lovely celebration today at ISB, for Mary. Beyond the work and the prize, it is worth highlighting that Mary is always friendly, collected, thoughtful, and very humble. Such a delight to see her recognized!!

Gov. Bob Ferguson@governorferguson.bsky.social · 12mo ago

Congratulations to Nobel Prize winner Mary Brunkow, a UW alum whose research in Seattle has led to important developments in addressing autoimmune disease, complications from organ transplants, and cancer. Washingtonians are among the most innovative people in the world.

"Announcing the Biomedical Data Translator: Initial Public Release" pubmed.ncbi.nlm.nih.gov/40635371/ Translator is the knowledge-graph integration system we're developing to support hypothesis generation by scientists. Funded by NCATS. As I said in the past, best consortium ever. Awesome people. 🧪

Announcing the Biomedical Data Translator: Initial Public Release - PubMed

The growing availability of biomedical data offers vast potential to improve human health, but the complexity and lack of integration of these datasets often limit their utility. To address this, the ...

pubmed.ncbi.nlm.nih.gov

Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.

Interesting new study on emergence and disruption of cooperativity in a denitrifying microbial community, by postdoc in the lab Alex Carr (from his PhD work with Nitin Baliga). academic.oup.com/ismej/articl...

Emergence and disruption of cooperativity in a denitrifying microbial community

Abstract. Anthropogenic perturbations to the nitrogen cycle, primarily through use of synthetic fertilizers, is driving an unprecedented increase in the em

academic.oup.com

Breakthrough in search for HIV cure leaves researchers ‘overwhelmed’

Breakthrough in search for HIV cure leaves researchers ‘overwhelmed’

Exclusive: Melbourne team demonstrates way to make the virus visible within white blood cells, paving the way to fully clear it from the body A cure for HIV could be a step closer after researchers found a new way to force the virus out of hiding inside human cells. The virus’s ability to conceal itself inside certain white blood cells has been one of the main challenges for scientists looking for a cure. It means there is a reservoir of the HIV in the body, capable of reactivation, that neither the immune system nor drugs can tackle. Continue reading...

theguardian.com

This is superbly interesting. Quite clear evidence of theory of mind at work.

Michelle says: Be kind. Always. ❤️@snarkysillysad.bsky.social · last yr.

Cats caught red-handed. #AGoodPlace Source: www.reddit.com/r/MadeMeSmil...

Youtube offered this to me today, likely because of my love for Hania Rani's music. Büşra Kayıkçı's music is delightful!

Juan Meliá@juanmelia.bsky.social · 2y ago

Büşra Kayıkçı - ARTE Concert's Piano Day youtu.be/UfDxBb39QBk?si… vía @YouTube

HAPPY 75th, NSF! We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond. Read on 🧵(1/11):

We are saddened to share the passing of Valerie Logan Hood, beloved wife of ISB Co-founder Dr. Lee Hood. Valerie’s dedication to K-12 education shaped ISB’s education programs & and her influence continues to be felt by students and educators in WA state and beyond. isbscience.org/news/philant...

Celebrating the Life and Legacy of Valerie Logan Hood

ISB is saddened to share the passing of Valerie Logan Hood, whose lifelong dedication to K-12 education shaped ISB’s education programs.

isbscience.org

Excellent message. Be kind to all!

🧪

ISB@isbscience.org · last yr.

Drs. Carl Murie, @nitinbaliga.bsky.social, and collaborators have developed a powerful new tool called mmSYGNAL that could transform how doctors treat multiple myeloma, a complex and often unpredictable blood cancer. isbscience.org/news/cancer/...

Fascinating and important read indeed. I'm sure there are plenty of cultural differences on this topic, too.

Laura Helmuth@laurahelmuth.bsky.social · 2y ago

This is an interesting piece by a psychologist about how giving a gift can sometimes make the recipient dislike you, and how to avoid that. Relationships are hard. slate.com/technology/2... on @slate.com

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

www.geekwire.com/2025/researc...

Researchers, politicians rally for science in Seattle as part of national protest against Trump cuts

The Stand Up for Science rally in Seattle, part of a nationwide effort, filled the mural amphitheater at the Seattle Center. (Photo courtesy of Bryn

geekwire.com

Stand Up for Science. Seattle.

This is indeed a beautiful graphic!

Buddha Powers U Adhisila ☸️ 🇨🇦 🇺🇸 🇲🇽 🇩🇰🇬🇱🇺🇦@adhisila.bsky.social · 2y ago

Love the image of investing in nature the returns are immeasurable 🙏💙🙏

I got laid off today, with the rest of 18F. 18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it. We made this website to tell our story: 18f.org

Data request! Do you assess frailty index in your aging C57 mouse studies? @dantong-zhu.bsky.social is making new and improved clocks to predict age and lifespan based on frailty data & we aim to validate widely! Reach out if you want to collaborate 🐀👵⏰ Especially if you have female data + lifespan!

As a great darkness falls over the US it becomes more and more important to be the light. Know the bad, but stick to the good Everything changes #metta

🚀 We're Hiring: Contracts Specialist! 🚀 Join @isbscience.org's Legal & Innovation team (Seattle, Hybrid) to manage contracts, NDAs, & licensing for cutting-edge research. 🔹 2+ yrs contracts/paralegal experience required 📌 Apply at isbscience.bamboohr.com/careers/42 Boost or tag a great candidate!

Contracts Specialist

The Institute for Systems Biology (ISB) is creating the future of health. ISB scientists make breakthrough discoveries in cancer, health, chronic and infectious disease, and environmental issues. The ...

isbscience.bamboohr.com

Another explainer, for those who prefer video animations. Please amplify, particularly to non-scientists. 🧪

Rebecca D. Burdine, PhD@rburdine1.bsky.social · 2y ago

Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social Please share widely! www.youtube.com/watch?v=yxTD...

not paying indirect costs for research is like only paying the players in the Super Bowl. can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities

A visual for the more visually oriented! What overhead/indirect costs actually pay for. 🧪

Aidan Milliff@aidanmilliff.com · 2y ago

Here's a good infographic from AAUP on what indirect costs fund. It's a lot of important things!

Great explainer for those not familiar with what indirect costs actually mean and do, in scientific research. 🧪

Sarah Tishkoff, PhD@sarahtishkoff.bsky.social · 2y ago

Apologies for this long post I put together to explain to non-scientists the impact of NIH cuts: Last night, an “atomic bomb” was dropped on the biomedical science community. We were informed that effective immediately, indirect costs on NIH grants (both current and future) would be fixed at 15%.