What is one of the differences between an interesting non-mainstream model and a model with huge potential? Genetic tools and microscopy. Great work from the Amro Hamdoun lab, and first author Yoon Lee. Glad to have modestly contributed.

Amro Hamdoun@hamdounlab.bsky.social · 4w ago

More than a decade since CRISPR-Cas9 knock in came on the scene, it's remained underutilized in emerging models. Using transposase, and a split-FP system, we built an optimized knock in system for use in the genetically-enabled urchin, Lytechinus pictus. bit.ly/4wswLsd

More than a decade since CRISPR-Cas9 knock in came on the scene, it's remained underutilized in emerging models. Using transposase, and a split-FP system, we built an optimized knock in system for use in the genetically-enabled urchin, Lytechinus pictus. bit.ly/4wswLsd

I just learned a lab appropriate alternative to rock, paper, scissors- Kelp, Urchin, Rock. Kelp covers the rock, urchin eats the kelp, rock squashes the urchin!

Fantastic!

Brandy A Freitas@brandy-syglass.bsky.social · last yr.

LIVE sea urchin larvae for #3DThursday! Catch me at the MIT Museum tonight at AfterDark and see it in person. 🔬: @brukercorporation.bsky.social TruLive3D 🥼: Amro Hamdoun @hamdounlab.bsky.social ‬, Tzer Han Tan's @tzerhan29.bsky.social group at UCSD 🌌: Painted Sea Urchin 🎥: syGlass.io #syGlass

Uniform.

Happy #FluorescenceFriday! Today we're celebrating a crowd-favorite - Lamin B1! This cell line and plasmid illuminates the nuclear envelope. Our entire Allen Cell Collection is available for just the cost of shipping from @coriellinstitute.bsky.social and @addgene.bsky.social. #CellLineOfTheWeek

Is it just me or does everyone’s lab look at them like they sprouted a third eye every time they invoke Maniatis in the lab? I swear that we isolated good nucleic acids in the 90s and we didn’t have Reddit.

“If you have a broken radio and you have the circuit diagram, you’ll be in a better position to fix it.” - Nuno da Costa Thank you @b0yle.bsky.social for sharing our publication of the most complete map yet of the brain's wiring and activity in @geekwire.com! 🧠📈 www.geekwire.com/2025/brain-m...

Scientists unveil new wiring diagram tracing millions of connections in a bit of brain tissue

Researchers say they have mapped more than 200,000 cells in a cubic millimeter of brain tissue and have traced how they're all connected.

geekwire.com

Have you used our datasets, atlases, protocols, cell lines, and other #OpenScience resources in your research or classroom? Tell us about it! Share your story with us at bit.ly/opensciences... Select stories will be shared on our social media channels during #OpenScienceWeek.

Distinct requirements for PI3K isoforms p110α and p110δ for PIP3 synthesis in mouse oocytes and early embryos Read this Research Article by Anne Bourdais, Guillaume Halet and colleagues: doi.org/10.1242/dev.... 🎥KitL activates oocyte PI3K

EMBOMtg Paris May 6-9 @aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social meetings.embo.org/event/25-dev...

Developmental timing across species: From mechanisms to evolutionary insights

Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…

meetings.embo.org

Nice work! Can’t wait to hear about this next week at DBSUMI.

Periklis Paganos@perievodevo.bsky.social · last yr.

Also a blast from the past! Another preprint is now available from my first postdoc in the @arnonelab.bsky.social at @szndohrn.bsky.social www.biorxiv.org/content/10.1...

This paper is now published at @diffjournal.bsky.social! Congratulations to all the hardworking students who made it happen! Shout out to authors 1 & 2! MJ is our “axolotl whisperer” and Raneesh is our computational wizard- both DVM/PhD students @ucdavisvetmed.bsky.social! 💫 doi.org/10.1016/j.di...

NSAID-mediated cyclooxygenase inhibition disrupts ectodermal derivative formation in axolotl embryos

Embryonic exposures to non-steroidal anti-inflammatory drugs (NSAIDs) have been linked to preterm birth, neural tube closure defects, abnormal enteric…

sciencedirect.com

Crystal Rogers, PhD@rogerslabucd.bsky.social · 2y ago

Please check out our recent preprint focused on understanding the cyclooxygenase signaling pathway and effects of pharmacologically inhibiting it in axolotl embryos! This work was spearheaded by MJ Marshall (molecular) and Raneesh Ramarapu (computational) in my lab with help from two undergrads.

NOW HIRING - @adc-neuroenv.bsky.social is seeking a postdoc researcher to develop and optimize genetically encoded fluorescent and bioluminescent sensors tailored for marine model organisms. Please repost and share to your networks! 🔗 www.adc-nice.org/postdoctoral... @nathanshaner.bsky.social

101 L. pictus genes! 32hours. drive.google.com/drive/folder...

And... it's live! In situ hybridization has been foundational for sea urchin developmental biology. Here we report a fully automated method to probe more than a hundred genes using a general purpose liquid handler.https://www.biorxiv.org/content/10.1101/2025.03.23.644641v1

The "superpower" of sea urchins is the fact that a single female can produce millions of embryos. In the next day or so we will share a new method to analyze gene expression methods in these embryos using a fully automated, open platform.

A paywalled article from @nature.com bemoaning the exploitation of scientists' unpaid labour. Chef's kiss. Perfection. No notes.

Nature@nature.com · last yr.

It can be hard to say no to service requests in academia. We sought advice on how to ensure researchers don’t get stuck doing unpaid labour https://go.nature.com/3FsSD1p