Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease

Nature Metabolism, Published online: 02 July 2025; doi:10.1038/s42255-025-01318-6High-resolution multi-omic profiling indicates widespread gut dysbiosis in individuals with MASLD, also affecting the virome, and reveals microbial signatures that can classify MASLD and its subtypes.

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Viewing MASLD through an integrative gut microbiome lens

Nature Metabolism, Published online: 02 July 2025; doi:10.1038/s42255-025-01300-2The gut microbiome is pivotal to the development of liver diseases in multifaceted ways. A recent study uses a multi-omics, multi-kingdom approach to analyse the gut dysbiosis in metabolic dysfunction-associated steatotic liver disease, highlighting a substantial role for oral-typical microorganisms and their associated metabolites.

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