The UK @biochemsoc.bsky.social is organising an early career symposium (9 November, 2026 in Birmingham, UK) on the skills needed for success beyond academia. The event is free for Society members (although a small deposit is required). Do take a look and register if interested...

✨ WE ARE HIRING! ✨ Are you a Crystallographer and interested in viruses? 💎 The Kreylab is looking for a motivated Postdoc to join our mission in fighting the Hepatitis E Virus! 🦠 Help us design the next generation of antiviral inhibitors using structural biology. 🚀 www.b-ite.com/recruitingma...

The LocScale 2.0 and SURFER papers are now both published in final form. LocScale 2.0: www.nature.com/articles/s41... SURFER: onlinelibrary.wiley.com/iucr/doi/10.... Led by @alok-bharadwaj.bsky.social with contributions of former MSc/Bsc students Reinier de Bruin and Lotte Veerbeek.

@emdatabank.bsky.social EMPIAR entry for stomatin complex from @fravallese.bsky.social and myself released - I hope it will be useful for folks studying #cryoem compositional heterogeneity in pseudo/mixed symmetry systems, as classifying out AQP1 and UT-B was quite a challenge for us at least!

Dear #cryoem community, does anyone if its possible disable atlas categorization in EPU? And if so, how?

We are pleased to release an update to this pre-print! Includes (1) proof-of-principle experiments on ultrasonic excitation during plunge vitrification, (2) cryo-ET characterisation of the effect, (3) and insights into grid/ice quality following ultrasonic excitation during vitrification.

Want to do a PhD combining cryo-EM, AI-driven binder design, and deep virology in a cutting-edge environment and in an international team? We're hiring @CSSB_Hamburg 🔬 You: curious, rigorous, MSc in biochem, biophysics, virology, related Interested? DM me. Please RT 🙏 #PhDposition #cryoEM #virology

We're recruiting for three Independent Trustees to join our Council of Trustees. Working closely with the wider Council to set strategy and maintain oversight, you'll gain valuable experience whilst helping to make a difference in the community. Apply by 22 May 2026: https://ow.ly/AtpV50YWxIj

Friday quiz: What is going on in this image (taken on a Titan, atlas mag)? 👀

📢 We are now recruiting a PhD student in Structural and Molecular Virology in Sweden 🇸🇪 Work on RNA viruses using cryo-EM and in situ cryo-ET, with access to world-class microscopy infrastructure Perfect for candidates with backgrounds in biochem, structural bio, and virology More info ⬇️

Can confirm, while I do like the cold, I am not stored in the fridge.

Always a fun time presenting at the @gesvirologie.bsky.social annual meeting, this time in Heidelberg. An exciting time for structural virology ahead!

What a privilege to have this 5 minutes away from the office. Has spring sprung?

Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...

If you're interested in how proteins of the innate immune response recognise and bind to pathogens (and/or how some microbes might avoid detection...), I invite you to read the paper now in press at the Journal of Biological Chemistry... www.jbc.org/article/S002... #crystallography

Phosphorylation of inner core heptose is a major determinant of bacterial surface lipopolysaccharide recognition by the innate immune protein hSP-D

The innate immune protein human surfactant protein D (SP-D) recognises pathogens in the lungs via binding to carbohydrate surface structures. SP-D targets gram-negative bacterial lipopolysaccharide vi...

jbc.org

Harry M. Williams@harrywilliams.bsky.social · last yr.

❄️ NEW PRE-PRINT ❄️ Happy to see the last chunk of protein X-ray crystallography work I completed for my PhD appear on bioRxiv. The result of an excellent and long-standing collaboration between colleagues at Keele, Southampton, MRC Harwell, and University College Dublin. Enjoy!

Paper accepted! 🎉 More Thursday’s like this, please.

We absolutely love Krios days. Screening grids, collecting data will get old.

And now out in Nature Comms (congrats Wyatt et al.): www.nature.com/articles/s41....

Harry M. Williams@harrywilliams.bsky.social · last yr.

A new paper from my new colleagues in Lausanne! Microsecond time-resolved cryo-EM rumbles closer day by day. Very cool work!

Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

Experimental structures provide valuable hypotheses and accelerate but do not replace evolutionary and statistical analyses of protein sequences

Mathieu M.J.E. Rebeaud@chercheurjuteux.com · 8mo ago

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination www.nature.com/articles/s41...

An integrated workflow for structural virology with a 100 keV electron microscope www.biorxiv.org/content/10.64898/2025.12.08.693081v1 #cryoEM

Happy to see our latest work online. Here we present a new method for microsecond time-resolved cryo-EM based on jet vitrification! Details in the 🧵 below... we hope you enjoy reading! (Hint, there's some fun videos...) #cryoEM #structuralbiology

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 9mo ago

Microsecond Time-Resolved Cryo-EM Based on Jet Vitrification https://www.biorxiv.org/content/10.1101/2025.11.21.689681v1

Always a good feeling!

MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony. Or from a single dish of HEK cell culture in the case of two membrane proteins. Out in Nature Methods now! lnkd.in/gpyBSceg Wonderful collaboration with the Efremov lab.

We are pleased to announce Doppio version 1.4! Available here www.ccpem.ac.uk/software/dow...

Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇

warwick.ac.uk/fac/cross_fa... I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays. If you're interested reach out and I'd be happy to have a chat.

Finally, just about 2 years after finishing the postdoc the last part of my work is finally online! We determined the structure of HSV-1 Origin Binding Protein, the viral initiator of DNA replication, by cryo-EM 🧪🧬🧶🧵 #cryoEM #structuralbiology

Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing Read more: www2.mrc-lmb.cam.ac.uk/a-new-method... #LMBResearch