@harvardmicro.bsky.social
We are excited to share two preprints reporting a mosquito-specific receptor for chikungunya virus and other alphaviruses! 🤩 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6... @harvardmicro.bsky.social @harvardvirology.bsky.social @hhmi-science.bsky.social
Excited to share this short video about our lab's work! Thank you Harvard Medicine News Team! @harvardmicro.bsky.social @hhmi-science.bsky.social @harvard.edu ❤️🎥😃https://www.youtube.com/shorts/GFM3KLZCDps
Harvard Medical School Scientists Working to Prevent the Next Pandemic
YouTube video by Harvard Medical School
youtube.com
A new study from the Rudner lab defines a comprehensive set of genes required for spore formation in Bacillus anthracis. Similarities and striking differences between the Bacillus subtilis model and this important human pathogen are described. pubmed.ncbi.nlm.nih.gov/41385520/
What We Need To Know To Stop a Listeria Outbreak: Darren Higgins, professor of microbiology in the Blavatnik Institute at Harvard Medical School, has been studying listeria and other intracellular bacteria for decades hms.harvard.edu/news/what-we...
Thank you to the Blavatnik Family Foundation and The New York Academy of Sciences for honoring our research uniting human innate immunity and bacterial anti-phage defense at @danafarber.bsky.social @harvardmicro.bsky.social @harvard.edu bit.ly/4pZUDkF blavatnikawards.org/news/items/t...
The mechanism of STING NF-κB signaling has remained a mystery. An exciting new study from the Paludan lab now uses data throughout animal STING evolution to provide new answers – including isolating white blood cells from turtles and carp! www.nature.com/articles/s41...
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor - Nature Immunology
Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling.
nature.com
TWiV 1253: Harvard virology is not retreating This Week in Virology - another great episode: www.microbe.tv/twiv/twiv-12...
TWiV 1253: Harvard virology is not retreating
Vincent travels to Waterville Valley, NH to attend the Harvard virology retreat, where he speaks with Aaron Schmidt, Ben Gewurz, and Tatum Sass about their careers and their research on influenza viru...
microbe.tv
Excited to share our new @natmicrobiol.nature.com paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩 www.nature.com/articles/s41...
Molecular organization of the New World arenavirus spike glycoprotein complex - Nature Microbiology
Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-depend...
nature.com
“I Am Determined to Carry On This Vital Work” David Knipe (knipelab.med.harvard.edu) studies how to prevent, combat, and make use of a virus that infects most people in the world: magazine.hms.harvard.edu/articles/i-a...
Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation - Nature Structural & Molecular Biology
Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and p...
nature.com
Brogan et al uncover a signaling pathway in which levels of the nucleotide second messenger c-di-AMP increase in response to defects in cell wall synthesis. This regulatory pathway decreases the cytoplasmic turgor pressure and protects the cell from lysis: www.nature.com/articles/s41...
Due to loss of research funding, we’ve had to terminate our Seminar Series -- a huge loss for our research community. We are happy to announce that through a private donor, we will be able to host some invited speakers’ again this fall. (1 of 2)
To support our research, click: micro.hms.harvard.edu/support-our-... or, to donate to the seminar series click on “contact us” at the bottom of the linked page. (2 of 2)
Support Our Research
Click here to support our researchScroll down to "Microbiology" under "Select a Fund"
micro.hms.harvard.edu
Joel Tan discovers a DNA molecular tripwire that guards against viral infection. New research from the Kranzusch (kranzuschlab.med.harvard.edu) and Jost (jostlab.org) labs in HMS Micro @nature.com www.nature.com/articles/s41...
Research from Renee Chang explains how viruses disrupt His-ADPR immune signaling. Kranzusch lab (kranzuschlab.med.harvard.edu), @soreklab.bsky.social, Tamulaitiene lab, @nature.com www.nature.com/articles/s41...
