We wrote a review 📖 on hydathode immunity! Learn how bacteria exploit hydathodes to access the vasculature and open questions for future research. 📣 If you are curious about this topic, please consider applying for two open positions in my lab (until Nov23)! www.sciencedirect.com/science/arti...

Hydathodes at the forefront of plant immunity against vascular pathogens

Hydathodes are tiny plant organs that form an interface between the leaf surface and xylem vasculature. They facilitate excretion of xylem fluid under…

sciencedirect.com

Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org ! www.science.org/doi/10.1126/...

Systematic discovery and engineering of synthetic immune receptors in plants

Plants deploy a diverse array of pattern recognition receptors (PRRs), which perceive microbe-associated molecular patterns to activate immune responses. Leucine-rich repeat receptor-like kinase subgr...

science.org

Finally a method to identify plant RNA-binding proteins! 🧬 This enables so much new biology to discover from immunity to development! 🤯 🪴 Established by the incredible Victor Sanchez with @havandenburg.bsky.social @uva.nl Congratulations!!

bioRxiv Plant Bio@biorxiv-plants.bsky.social · last yr.

Protocol for capturing the RNA-binding proteome from plants using orthogonal organic phase separation https://www.biorxiv.org/content/10.1101/2025.07.29.667348v1

www.nature.com/articles/s41... Brilliant new strategy to obtain broad resistance against Potyviruses, and possibly other protease-encoding viruses

Remodelling autoactive NLRs for broad-spectrum immunity in plants - Nature

Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.

nature.com

Hydathode immunity 🌱 - the discovery journey continues ... ⏩ Today: Immune receptor SUT1 confers resistance against #Xanthomonas pathogens in hydathodes. In the latest version, we contrast the tissue-specificity of SUT1 with the well-known ZAR1 resistance. journals.plos.org/plospathogen...

Arabidopsis CNL receptor SUT1 confers immunity in hydathodes against the vascular pathogen Xanthomonas campestris pv. campestris

Author summary Black rot disease, caused by the bacterial pathogen Xanthomonas campestris pv. campestris (Xcc), is an economically important disease of cabbage crops. Xcc is unique in that it enters t...

journals.plos.org

Happy to share that our Helixer deeplearning-based annotation of 230 superasterid genomes is now online on @datadryad.bsky.social 💻🌱 doi.org/10.5061/drya... Check out how we used 69 of them to study the molecular evolution of a plant immune receptor network here! 👇

AmirAli Toghani@amiralito.bsky.social · 2y ago

🧵 🥬 Lettuce begin! Super excited to share our new manuscript on contrasting patterns of evolution in sensor and helper NLRs in the NRC network! Tune in for some plant immunology and molecular evolution… 🌱🧬💻 (1/14) www.biorxiv.org/content/10.1...

Reciprocal phosphorylation between SOAK1 and SOBIR1 fine-tunes receptor-like protein (RLP)–mediated plant immunity @science.org #ScienceAdvances www.science.org/doi/10.1126/...

Reciprocal phosphorylation between SOAK1 and SOBIR1 fine-tunes receptor-like protein (RLP)–mediated plant immunity

SOAK1-SOBIR1 module fine-tunes receptor-like protein (RLP)–mediated plant immunity.

science.org

Huanglongbing causes crop damage worth $10 billion annually, and most trees die within a few years once infected. This week in a new Science study, researchers report that they have developed therapeutic peptides that may be able to save and revive infected citrus trees. scim.ag/4jtM8dC

Beautiful paper

Exogenous RNA surveillance by proton-sensing TRIM25

Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

science.org

How Bacteria Outsmart Plants—Then Flee the Scene! #MicroSky #PlantScience #Pseudomonas Our new research in Nature Microbiology uncovers the sophisticated teamwork of Pseudomonas syringae, a notorious plant pathogen. 🔗 rdcu.be/egczU

Pseudomonas syringae subpopulations cooperate by coordinating flagellar and type III secretion spatiotemporal dynamics to facilitate plant infection

Nature Microbiology - Single-cell gene expression analysis reveals phenotypic heterogeneity to enable bacterial specialization over the course of plant colonization.

rdcu.be

Delighted to have our Perturb-multiome paper, led by #JorgeMartinRufino and @hemagene.bsky.social from our lab, published today in @science.org. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: www.science.org/doi/10.1126/...

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes

Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

science.org

David Liu receives Breakthrough Prize in Life Sciences. Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. www.broadinstitute.org/news/david-l...

David Liu receives Breakthrough Prize in Life Sciences

Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine.

broadinstitute.org

Le Naour--Vernet et al. Structure‐guided insights into the biology of fungal effectors nph.onlinelibrary.wiley.com/doi/full/10.... featuring MycFOLD effectors

Oh yes. This is new. Non-NLR and NLR pair for immune sensor and executor! www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

A wheat tandem kinase and NLR pair confers resistance to multiple fungal pathogens

Tandem kinase proteins underlie the innate immune systems of cereal plants, but how they initiate plant immune responses remains unclear. This report identifies wheat protein wheat tandem NBD 1 (WTN1)...

science.org

Yes, that's a proteasome! Guess where it is....in the apoplast! Nice to see Richard Vierstra's work out! #PPStasis #proteostasis #proteasomes #PlantSci www.nature.com/articles/s41...

Check out our new study! We show that Arabidopsis uses the EDS1-SAG101-NRG1 node to trigger rapid yet contained cell death. Key finding: NRG1C variant regulates this process by competing with functional NRG1s. Amazing collaboration between Jijie Chai and Parker Labs. www.nature.com/articles/s41...

Great new study from our lab revealing insights in Xanthomonas evolution and how loss of the Crispr genome defense was a key step for X. campestris pv campestris.

@pfeilmeier.bsky.social · 2y ago

➡️ New insights into the evolution of the vascular pathogen Xanthomonas campestris involving the genome defense system CRISPR-Cas! www.cell.com/current-biol... Our data wizard 🪄@mpaauw.bsky.social sequenced almost 100 genomes and this is what he found … /

Lighten up your life! We built a “darkbox” with a CCD camera to image bacterial infections across entire trays of Arabidopsis plants. Our technical advance with Python image analysis pipeline out now! @havandenburg.bsky.social @nwtaks.bsky.social bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...

Non‐Invasive, Bioluminescence‐Based Visualisation and Quantification of Bacterial Infections in Arabidopsis Over Time

Development of a non-invasive high-throughput phenotyping pipeline to visualise and quantify progression of bioluminescent bacterial pathogens in Arabidopsis rosettes over time.

bsppjournals.onlinelibrary.wiley.com