TIRs are key regulators of plant immunity, but the role of conserved TIR-only proteins has remained unclear. Here, we compare TIR-only proteins from Arabidopsis and barley and show that they share a conserved role in plant immunity. www.biorxiv.org/content/10.6...

Conserved TIR-only proteins drive transcriptional defense and basal immunity in dicot and monocot plants

Toll/interleukin-1/resistance (TIR) domain NADase enzymes signal in plant immunity by producing ribosylated nucleotide second messengers which activate EDS1 dimer-helper NLR pathways to restrict patho...

biorxiv.org

Great to see this really cool story published in Nature! rdcu.be/e7UoR Parker & Wang’s commentary, “A fellowship of the rings in plant defence”, provides further insights into the elaborate structures of NLRs formed during plant immunity. rdcu.be/e7UnA @nature.com @mpipz.bsky.social

Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR

Nature - SUMM2, a coiled-coil NLR, promotes the assembly of higher-order resistosome clusters to initiate cell death in plants.

rdcu.be

This week we will hear @federicalocci.bsky.social (from @parkergroup.bsky.social, @mpipz.bsky.social) talk about "How not to die", workings of TIR-networks in damage and systemic resistance. 📅 Jan 16 | 🕥 10:15 |📍KS 00.009 #PlantScience If you want to know more, check out their review below. 👇🏼

Royal Society Publishing@royalsocietypublishing.org · last yr.

ICYMI #OpenBiology review - Plant NLR immunity activation and execution: a biochemical perspective: royalsocietypublishing.org/doi/10.1098/... #biochemistry #immunology

How do plants fight disease? 🌱 #NASmember Jane Parker studies NLR proteins that help plants sense attackers and launch powerful immune defenses. She shares her latest findings on how these proteins signal plants to resist disease in a new @pnas.org QnAs: www.pnas.org/doi/10.1073/...

👏 Congratulations to Dr. Lara Van Dijck from Jane Parker’s lab @mpipz.bsky.social on successfully completing her PhD! Wishing you continued success ahead! 🎓🌱 #PhDSuccess #PlantScience #PhDone #ScientificAchievement

Many thanks to Dr. Dmitry Lapin for writing a highlight of our collaborative study and sharing it on his lab’s website. Learn more about coordinated Ca²⁺ influx cascades for quantitative control of plant immunity here: phoenix-plant.com/highlights-o...

News in plant immunology

Contents Coordinated Ca2+ influx cascades for quantitative control of plant immunity Coordinated Ca2+ influx cascades for quantitative control of plant immunity Written by Dmitry Lapin, J…

phoenix-plant.com

🚨 New paper alert! Our work is published in PNAS! @junli-wang.bsky.social @mpipz.bsky.social In this study, we uncover how NLR-assembled and canonical Ca2+ ion channels cooperate to confer robust resistance against disease in plants. Check it out here: www.pnas.org/doi/10.1073/...

Great to see this really cool story (see quoted post) published in @newphyt.bsky.social! nph.onlinelibrary.wiley.com/doi/full/10.... Congratulations @laravdijck.bsky.social, @parkergroup.bsky.social! Plant-Scopoletin-Fungal Endophyte-Iron #PlantScience #Coumarin #PlantImmunity #PlantNutrition

Cooperation between a root fungal endophyte and host‐derived coumarin scopoletin mediates Arabidopsis iron nutrition

Iron acquisition is a critical challenge for plants, especially in iron-deficient soils. Recent research underscores the importance of root-exuded coumarins in modulating the root microbiome communi...

nph.onlinelibrary.wiley.com

Marc Somssich@somssich.bsky.social · last yr.

This is such a cool story! ➡️ Arabidopsis produces scopoletin to fend off pathogens. ➡️ The beneficial M. phaseolina converts scopoletin to esculetin, thus evading its negative effects & out-competing pathogens. ➡️ Esculetin serves as iron-chelating coumarin to support the plant. #PlantImmunity

Super excited to share that my PhD research paper is finally out! @newphyt.bsky.social doi.org/10.1111/nph.... @parkergroup.bsky.social

Cooperation between a root fungal endophyte and host‐derived coumarin scopoletin mediates Arabidopsis iron nutrition

Iron acquisition is a critical challenge for plants, especially in iron-deficient soils. Recent research underscores the importance of root-exuded coumarins in modulating the root microbiome communi.....

doi.org

Parker Group alumni, from the early 2000s to 2025, the best folks! Grateful for everyone who helped shape the science over the years #2025ISMPMI Thanks @federicalocci.bsky.social for taking the picture

Want to learn more about fungal-coumarin-iron interactions in the rhizosphere? Come to my poster 240 on Thursday #2025ISMPMI

Great talk at #2025ISMPMI by @federicalocci.bsky.social on a TN protein in systemic resistance. So happy to catch up on @parkergroup.bsky.social projects!

We are happy to announce another PhD success at @mpipz.bsky.social! 🎉 Dr. Henriette Läßle has passed her viva in Jane Parkers’s lab. Huge congrats, Dr. Läßle, and best of luck with your next steps! 🚀🌱🎓 #PhDSuccess #PlantScience #PhDone

Big news! 🎉 Dr. Fei Xiong has passed his PhD viva in Jane Parker’s Lab at @mpipz.bsky.social, defending his thesis: "Probing the link between EDS1-PAD4 and transcriptional reprogramming in Arabidopsis thaliana." Congrats, Dr. Xiong! Wishing you success in the future! 🎓✨ #PhDone

Deadline extended! You wanted more time, and we heard you. The #2025ISMPMI Congress abstract submission deadline is now March 26. Don’t miss your chance to present your research and connect with top scientists! Submit now: www.ismpmi.org/Events/2025C...

Congratulations Marc @somssich.bsky.social 🥇🎊 He receives this year's #SciComm Award of @molplantsci.bsky.social for explaining #plantsci results by putting them into the respective historic contexts and for portraying plant scientists. Read more: www.pflanzen-molekularbiologie.de/en/sci-comm#...

MolPlantSci@molplantsci.bsky.social · last yr.

🌿🏆 Congratulations to Marc Somssich! 🏆🌿 @somssich.bsky.social He receives the 2025 SciComm Award for outstanding social media contributions bringing scientific discoveries and plant scientists to life through engaging storytelling and historical context. Well deserved! 👏 #SciComm #PlantSci #MBP2025

Check out our new study! We show that Arabidopsis uses the EDS1-SAG101-NRG1 node to trigger rapid yet contained cell death. Key finding: NRG1C variant regulates this process by competing with functional NRG1s. Amazing collaboration between Jijie Chai and Parker Labs. www.nature.com/articles/s41...

www.nature.com/articles/s41...

Balanced plant helper NLR activation by a modified host protein complex - Nature

In Arabidopsis, mechanisms for NRG1A activation by recognition of a modified host EDS1–SAG101 complex, and NRG1A inhibition by NRG1C through sequestration of activated EDS1–SAG101, show activation and...

nature.com