Took me a while to get the new uga address, but my lab website is finally live. lewislab.uga.edu
Hooman Hefzi
@hefzi-lab.bsky.social
PI of the Advanced Mammalian Cell Engineering Lab at the Technical University of Denmark http://bioengineering.dtu.dk/amce
After ~8 years, happy to share work done w/ @natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social! www.nature.com/articles/s42... #science #biotech #cancermetabolism Thread below:
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature Metabolism
Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...
nature.com