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Nathan Lewis

@natelewis3.bsky.social

GRA Eminent Scholar and Professor at University of Georgia. Into Systems Biology, genome editing, cell-cell interactions, glycobiology, metabolism, biologics, and lots of other cool science stuff. Http://lewis.uga.edu

31 Posts614 Follower292 Folgt
Nathan Lewis@natelewis3.bsky.social · last mo.

Hooman Hefzi (DTU), a Prior student of mine, is running a really cool mammalin syn/sysbio lab now. He's hiring systems and structural bio postdoc now. efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

Postdoc in in silico systems and structural biology of mammalian cell lines for biotherapeutic protein production - DTU Bioengineering

Ready to engineer the next generation of CHO cell lines? As a postdoctoral researcher, you’ll use a range of computational tools to design pathways, understand cellular responses, and guide subsequent...

efzu.fa.em2.oraclecloud.com

Nathan Lewis@natelewis3.bsky.social · 11mo ago

Got a great score for a vaccine proposal and yet fearful about if it will be funded. Maybe my next proposal will fare better? "Intersectional Bias, Woke Adjuvants, and Inclusive Nanoparticle Vaccines: Disinformation-Resilient Immunity in Trans-genic Mice and Women". Fundable?

Nathan Lewis@natelewis3.bsky.social · 12mo ago

I love this visual of what I've been telling my kids / students, but I add that immediate answers rob our creativity too. I regularly ask myself "i can prompt this, but how important will my struggle be here?" Some tasks are perfect for AI. For others I choose to stimulate creativity & learning.

Nick Sousanis@nsousanis.bsky.social · 12mo ago

In my talks this wk, I placed my notion of the importance of drawing badly to find unexpected connections alongside my Ai statement - we need that struggle, to make mistakes in order to be surprised - it’s the decisions along the way that make us who we are and there is no shortcut to getting there…

a slide with some scribbly sketches and then a snippet of a finish comics page based on those sketches, with words "I've realized I'm very good at drawing badly - which is key to finding connections and making discoveries in my own drawings..." and then a snippet of a mini-comic, at top - straight line stretches from point A to B. Immediately below, same dot at A, then becomes a curving, meandering line that winds through the page and ends at a point with rays and a question mark emanating from it. Text reads: "Nothing can do this for you - for that robs you of experience and conflates answers with learning. Rather, it's all the decisions you make along the way, the mistakes, struggles, and surprises! These pathways you create - this is learning.
BioF:GREAT@biof-great.bsky.social · last yr.

The team at BioF:GREAT is always on the lookout for new protein design models that care about more than just the backbone! We are excited to try the new RFdiffusion3 (RFD3)! 🚀 New preprint from David Baker!🚀 🧪 #ProteinDesign #DeepLearning #ComputationalBiology www.biorxiv.org/content/10.1...

De novo Design of All-atom Biomolecular Interactions with RFdiffusion3

Deep learning has accelerated protein design, but most existing methods are restricted to generating protein backbone coordinates and often neglect interactions with other biomolecules. We present RFd...

biorxiv.org

Nathan Lewis@natelewis3.bsky.social · last yr.

Excitng collaboration in which we expressed a hepatitis c vaccine candidate in a panel of glycoengineered CHO cell lines. This allowed us to find a specific glycan structure that greatly improved immunogenecity, even for more distant strains #glycotime www.nature.com/articles/s41...

Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity - npj Vaccines

npj Vaccines - Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity

nature.com

Nathan Lewis@natelewis3.bsky.social · 2y ago

While our first discovery of this occurred just weeks into the shutdown, it's great to see it off bioRxiv now. SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. Great collab with Knight and Esko labs and many others #glycotime journals.asm.org/doi/10.1128/...

SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx | mBio

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019, can infect the gastrointestinal (GI) tract, and individuals who exhibit GI symptoms of...

journals.asm.org

Nathan Lewis@natelewis3.bsky.social · 2y ago

With all of the US government science chaos going on, I'm curious if anyone knows which governments are seeing the great opportunity to recruit top labs and tech companies, to bolster their international presence, and to reverse the brain drain.

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Hooman Hefzi@hefzi-lab.bsky.social · 2y ago

After ~8 years, happy to share work done w/ @natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social! www.nature.com/articles/s42... #science #biotech #cancermetabolism Thread below:

Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature Metabolism

Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...

nature.com