We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations. www.evocellnet.com/2026/03/mapp...
Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration
We are excited to announce the early-stage release of our S. cerevisiae structural interactome mapping project. Using AlphaFold3 (AF3), w...
evocellnet.com
Proud of our new paper just out in the @genetics-gsa.bsky.social's #GENETICS journal academic.oup.com/genetics/adv...!
Genetic and environmental determinants of multicellular-like phenotypes in fission yeast
Abstract. Multicellular fungi have repeatedly given rise to primarily unicellular yeast species. Some of these, including the fission yeast Schizosaccharom
academic.oup.com
Nice new paper by Mariella Obermaier in the Ralser Lab to understand interactions between common drugs co-administered with antifungals and antifungals on C. albicans pubmed.ncbi.nlm.nih.gov/40720257/
Non-antifungal medications administered during fungal infections drive drug tolerance and resistance in Candida albicans - PubMed
<span><b>Introduction.</b> Fungal infections are increasingly concerning, particularly in immunocompromised patients. These patients often suffer from comorbidities and receive multiple, non-antifunga...
pubmed.ncbi.nlm.nih.gov
Nice work by @maxhaase.bsky.social about the strange history of yeast centromeres - got to see him present it at #yeast2025
Max Haase@maxhaase.bsky.social · last yr.It’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres” www.biorxiv.org/content/10.1...
It’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres” www.biorxiv.org/content/10.1...
Ancient co-option of LTR retrotransposons as yeast centromeres
The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...
biorxiv.org
NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus! www.nature.com/articles/s41... #alphafold #evolution #genomics
A paper I have been working on with Oliver Lemke in the Ralser lab has just come out: www.nature.com/articles/s41... We used predicted structures to gain insight into the evolution of metabolic proteins in yeast. A bit more in this linked-in post (www.linkedin.com/posts/benjam...).
The role of metabolism in shaping enzyme structures over 400 million years - Nature
By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...
nature.com
how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)
Melania D'Angiolo@melaniadangiolo.bsky.social · last yr.Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response. www.biorxiv.org/content/10.1...