Sarah Heuer
@heuerwego.bsky.social
Postdoctoral researcher in the Young-Pearse lab studying the genetic mechanisms of Alzheimer’s disease using human-derived stem cell models. Avid cat lover. Opinions are my own.
Tracy and our fabulous postdoc @kelliannealexa1.bsky.social both gave fantastic talks on their work using IPSC models to study vascular dysfunction in AD at the @jax.org Vascular Contributions to Cognitive Impairment workshop! Thank you to the organizers for such an amazing meeting!
Shout out to our fabulous postdoc @heuerwego.bsky.social who gave a great talk on her work leveraging iPSC models to uncover how genetic risk factors influence dysfunction in microglia in AD at the ACT Research Symposium hosted by the Kaiser Permanente Washington Health Research Institute! #ACT2026
Very cool to have ABCA7-centric presentations from AD/PD featured by Alzforum, including the work presented by @typlab.bsky.social that I've been working on over the past few years! www.alzforum.org/news/confere...
Lipids, Lysosomes, and Plaques: How ABCA7 Nudges Up Alzheimer’s Risk | ALZFORUM
alzforum.org
New TYP lab publication from co-authors Zach Augur and @garrettfogo.bsky.social on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications
Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...
link.springer.com
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉 The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
Huge shoutout to our brilliant graduate student @gizemterzioglu.bsky.social for delivering a fantastic talk at the HMS Neurobiology Pizza Talk series! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.
🧠 New study led by our talented graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13. Check it out here in Brain: academic.oup.com/brain/articl...
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academic.oup.com
Highlights from our lab at the @keystonesymposia.bsky.social Neurodegeneration meeting! @heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s @alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...
cell.com
Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬 Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠 🔗 gbm-online.de/de/studium-k...
GBM-Masterpreis - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.
gbm-online.de
Honored to have been awarded the Martha Ondrey Junior Investigator Award for my postdoc work in @typlab.bsky.social!
Rush Alzheimer's Disease Center@rushalzheimers.bsky.social · last yr.With the support of Dr. Frank Ondrey, the RADC is pleased to present the Martha Ondrey Postdoctoral Prize to Sarah Heuer, PhD. Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.
Big shoutout to our lab at the annual ROSMAP meeting in Chicago! 🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆 🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!
Cool to see my PhD mentor’s work highlighted!!
The Jackson Laboratory@jax.org · last yr.What if a routine eye scan could tell a doctor if you were at risk of Alzheimer’s disease? At JAX, Gareth Howell is exploring how genetics shape the way our eyes—and brains—age. #medicine #genetics #research #science 🧪 🧬 🧠 #neuroskyence
Emma has become such an impactful member of the lab and will truly be missed!! Big things ahead for this young neuroscientist!
Young-Pearse Lab@typlab.bsky.social · last yr.A big day for the TYP lab! Master's student Emma successfully defended her incredible thesis work today where she's been working with @gizemterzioglu.bsky.social on studying how SHIP1 regulates lysosomal function in microglia. She will be missed!
Some TYP members attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @gizemterzioglu.bsky.social & postdoc @kelliannealexa1.bsky.social gave amazing short talks, Master's student Emma & postdoc @heuerwego.bsky.social got great poster traffic!
Thrilled to share my first first-author paper is out @cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes. Read here www.sciencedirect.com/science/arti...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…
sciencedirect.com
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read! www.cell.com/neuron/abstr...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...
cell.com
Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.
Honored and excited to be part of the @brightfocus.bsky.social community, and have funding for my postdoctoral work on ABCA7 genetic variants in Alzheimer's disease!
Young-Pearse Lab@typlab.bsky.social · last yr.Congratulations to TYP lab Postdoctoral Research Fellow @heuerwego.bsky.social on being awarded a @brightfocus.bsky.social Alzheimer's Disease Research Fellowship! Sarah is using iPSCs to determine the cellular impacts of ABCA7 mutations in Alzheimer's disease!
Some members of the TYP lab had a great (and only mildly frigid) outing to Fenway to see the Red Sox play this week!
The final bit of my PhD work from the Sanderson Lab is now out in iScience! Agent-based modeling of neuronal mitochondrial dynamics using intrinsic variables of individual mitochondria: iScience www.cell.com/iscience/ful...
Agent-based modeling of neuronal mitochondrial dynamics using intrinsic variables of individual mitochondria
Mitochondrial networks undergo remodeling to regulate form and function. The dynamic nature of mitochondria is maintained by the dueling processes of mitochondrial fission and fusion. Dysfunctional mi...
cell.com
@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"
Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"
For anyone headed to ADPD next week, be sure to come by Zach's poster and Gizem's talk to learn about all the cool work they've been doing!
Young-Pearse Lab@typlab.bsky.social · last yr.If you're headed to #ADPD next week, be sure to stop by the TYP lab presentations by @gizemterzioglu.bsky.social and Zach Augur to learn about some of the amazing work the lab is doing!
Happy to share a large part of my PhD work that is now published in Autophagy! www.tandfonline.com/doi/full/10....
Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion
Mitochondrial damage and dysfunction are hallmarks of neuronal injury during cerebral ischemia-reperfusion (I/R). Critical mitochondrial functions including energy production and cell signaling are...
tandfonline.com
Proud of our amazing postdoc @kelliannealexa1.bsky.social who gave a fantastic talk today on her work with neuronal hyperexcitability and modeling blood-brain-barrier dysfunction in Alzheimer's disease today as part of the BWH Neuroscience Seminar Series!
PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease https://www.biorxiv.org/content/10.1101/2025.02.24.639868v1
Congratulations @zacharyrmurphy.bsky.social on becoming a PhD candidate!
Young-Pearse Lab@typlab.bsky.social · last yr.Congratulations to PhD student @zacharyrmurphy.bsky.social for passing his preliminary exams and officially becoming a PhD candidate through the Harvard BBS program! Zack is excited to get started on his project using stem cell models to investigate sex differences in AD!
