Please join us for a BCMP seminar on Thursday, May 8 at 2pm by Jennifer Listgarten, Professor, Dept of Electrical Engineering and Computer Science, the Center for Computational Biology, and the Bioengineering program at UC Berkeley. @jlistgarten.bsky.social @ucberkeleyofficial.bsky.social

Read all about Apoorva Baluapuri’s new work on Integrator (INT) in HMS News! @baluapuri.bsky.social @adelmanlab.bsky.social tinyurl.com/y2fx22c2

What Happens When a Gene Quality-Control Mechanism Fails?

Study solves riddle of how mutations in Integrator complex relate to neurodegeneration, cancer

tinyurl.com

Congrats to Stephen Buratowski and Johannes Walter for being elected to the Academy of Arts & Sciences! www.amacad.org/new-members-...

New Academy Members

Elected in 2025

amacad.org

Published today in Cell Chemical Biology, our Cryo-EM structure of PP2A/B55α with IER5 and identification of IER5 structural homologues SERTADs using structural bioinformatics. Congratulations to Aster and @blacklowlab.bsky.social authors! www.sciencedirect.com/science/arti...

Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5

PP2A serine/threonine phosphatases are heterotrimeric complexes that execute many essential physiologic functions. These activities are modulated by a…

sciencedirect.com

Exciting new work from Apoorva Baluapuri of the Adelman lab! @baluapuri.bsky.social @adelmanlab.bsky.social www.sciencedirect.com/science/arti...

Integrator loss leads to dsRNA formation that triggers the integrated stress response

Integrator (INT) is a metazoan-specific complex that targets promoter-proximally paused RNA polymerase II (RNAPII) for termination, preventing immatur…

sciencedirect.com

Apoorva Baluapuri@baluapuri.bsky.social · last yr.

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

Please join us for a BCMP seminar on Thursday, April 3 at 2pm by Sebastian Klinge, Lenore C. Ford Professor, Dept of Biochemistry, Biophysics, Chemical Biology & Structural Biology, at The Rockefeller University. @rockefelleruniv.bsky.social

Please join us for a BCMP seminar on Thursday, March 20 at 2pm by Natalia Jura, Professor, Dept of Cellular and Molecular Pharmacology and Cardiovascular Research Institute at UCSF. @uofcalifornia.bsky.social

Please join us for a BCMP seminar on Thursday, March 6 at 2pm by Tanja Kortemme, Professor, Dept of Bioengineering & Therapeutic Sciences, Vice Dean of Research, UCSF School of Pharmacy. @uofcalifornia.bsky.social

This was a great collaboration and culmination of a huge amount of work including our first attempt to join #teamtomo. @ruizhangmt.bsky.social expertly summarizes the highlights below:

Rui Zhang@ruizhangmt.bsky.social · 2y ago

Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and @alanbrownhms.bsky.social www.nature.com/articles/s41...

Please join us for a BCMP seminar on Thursday, February 13 at 2pm by Andrew Carter, Program Leader, MRC Laboratory of Molecular Biology. @mrclmb.bsky.social

Please join us for a BCMP seminar on Thursday, January 30 at 2pm by Ed Boyden, Depts of Brain and Cognitive Sciences, Media Arts and Sciences, and Biological Engineering, Co-Director, MIT Center for Neurobiological Engineering Co-Director, K Lisa Yang Center for Bionics @mitofficial.bsky.social

Join BCMP Faculty, Karen Adelman, at the Epigenetics in Development and Disease Meeting in Banff March 30-April 2.

Keystone Symposia@keystonesymposia.bsky.social · 2y ago

February 19 is your last chance to get a $200 discount on the joint Epigenetics/Chromatin Architecture and Transcription Regulation meeting. #KSEpigenetics25 #KSChromatin25 #epigenetics #humandevelopment #developmentalbiology #​​chromatin #chromatinarchitecture youtu.be/zwUnqEdZduk

A new handle for understanding depression and the gut-brain connection? BCMP faculty Jon Clardy and colleagues report bacterial metabolism of environmental contaminant DEA drives cytokine IL-6 release. #microbiome #chemisky @pubs.acs.org

Drawing a Line From the Gut Microbiome to Inflammation and Depression

Study provides explanation for one bacterium’s link to mental health

tinyurl.com

Can (and do) bugs make drugs? Learn about @hms-bcmp.bsky.social faculty Sloan Devlin and Jon Clardy, among other researchers, in the @harvardmagazine.bsky.social article exploring exciting work at @harvardmed.bsky.social decoding the chemistry of the microbiome! #microbiome #chemisky rb.gy/9hz8wu

Decoding the Chemistry of the Microbiome

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Please join us in person for a BCMP seminar on Thursday, January 16 at 2pm by Stephen Bell, Professor, Dept of Biology and HHMI Investigator. Please note the new location: Armenise Amphitheater Room 125. @mitofficial.bsky.social @hhmi.bsky.social