Drs. HC Hodges @hodgeshc.bsky.social, #chanyuensan, K Cermakova @cermakova.bsky.social et al discovered a molecular bridge that facilitates interactions among disordered proteins involved in regulating #geneExpression. #BetaCatenin @bcmhouston.bsky.social #MolecularCell blogs.bcm.edu/2025/07/24/f...

A molecular bridge helps disordered proteins work properly

The findings reveal that despite their disordered nature, the protein interactions that drive gene expression are surprisingly modular and even have an underlying organization.

blogs.bcm.edu

How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions. www.cell.com/molecular-ce...

What do SWI/SNF-addicted cancers have in common? And when are they most sensitive to SWI/SNF inhibition? Check out Katka’s thread highlighting our most recent paper

Katerina Cermakova@cermakova.bsky.social · 3y ago

For the first time, we find a common mechanism for SWI/SNF addiction in cancer! Our paper reveals that G1 phase is a critical junction for SWI/SNF activity in several addicted cancers, including neuroblastoma, AML, prostate cancer, and uveal melanoma academic.oup.com/nar/advance-... (1/6)

A labor of love - our review on why IDRs matter for cellular function is live in Nat. Rev. Mol. Cell. Biol: www.nature.com/articles/s41... Working with Birthe Kraglund on this was such a pleasure, and we hope this review will be helpful to a broad audience!