My dream of being a … *gulp* … podcast guest has finally come true! Thanks, @boron110.bsky.social for the fun & freewheeling conversation!

Sar Crespi@boron110.bsky.social · 4w ago

Looking back at the first 10 years of Science Immunology—this week on the @science.org podcast. Editor @immunoeditor.bsky.social explores how the field has changed since the inception of the journal and talks about a special series of reviews on immune memory www.science.org/content/podc...

#Science #Immunology turns 10 years old this month! We celebrate w/ a Special Issue on immune #memory! Check out our 3 outstanding Reviews by Maziar & Kaufmann; @sjturn.bsky.social, Thiele, & @niclag.bsky.social; & @maurogaya.bsky.social & @kimljacobson.bsky.social out this week! scim.ag/448rEkV

To celebrate @focisimmunology.bsky.social's annual meeting this week, #Science #Immunology has just released a free sample collection of recent papers with a focus on human & clinical immunology! The collection will be available online to read for the next few weeks! #FOCIS2026 bit.ly/SciImm_free

To mark World #Malaria Day, here are 2 recent Science #Immunology papers highlighting cutting-edge malaria research! Nideffer & al. (2025) scim.ag/4izhn63 Gao & al. (2025) scim.ag/4hN5vOY

So far in March, we've featured papers on: • how inflammatory #ILC2 migrate • engineering #CAR-TCells to restore #checkpoint sensitivity • capturing the earliest events of #TCell #development • how certain dietary antigens recognized by #Tregs help mediate #OralTolerance New content every week!

Science Magazine@science.org · 5mo ago

The March 2026 issue of #ScienceImmunology is out! This month's cover highlights how intestinal regulatory T cells in mice recognize food-derived antigens such as the maize protein αZein and suppress immune responses to them. Learn about this research and more: https://scim.ag/4rL6F1I

Ghreetings from ghorgeous Ghent, where #Type2Immunity26 co-org by @vibtrainconf.bsky.social & #Science #Immunology is well under way! Check out our free collection of #allergy, #asthma, & #Type2Immunity papers in celebration! Collection: bit.ly/SciImm_free Conference: vibbio.tech/3UwmTNk

Out now in #Science #Immunology! 👇

Casanova Lab@casanovalab.bsky.social · 5mo ago

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

To celebrate next week's #Type2Immunity26 meeting in Ghent co-org by @vibtrainconf.bsky.social & #Science #Immunology, we've selected 8 recent #allergy, #asthma, & #Type2Immunity papers. Free collection available until end April 2026! Collection: bit.ly/SciImm_free Conference: vibbio.tech/3UwmTNk

Check it out! New content each week!!!

Science Magazine@science.org · 6mo ago

The February 2026 issue of #ScienceImmunology is out! This month's cover highlights how the cohesin complex shapes genome organization in dendritic cells to regulate their differentiation and function. https://scim.ag/4agVpT8

@science.org is looking for a new research editor to handle papers in the field of next-generation #medicine! Spread the word!!! bit.ly/4bWOJfn

The January 2026 issue of #Science #Immunology is out now! Thanks to Rioka Hayama for another fantastic cover!!!

Science Magazine@science.org · 7mo ago

The January 2026 issue of #ScienceImmunology is out! This month's cover depicts the repopulation of resident cardiac macrophages after chemotherapy, protecting the heart against subsequent injury. Learn more about this research and more: https://scim.ag/3NsLjqu

Happy 2026!!! #Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026! bit.ly/SciImm_free #ScienceImmuno10gy

#Science #Immunology will be sponsoring a prize for the best poster presentation! The abstract deadline is fast approaching though, so don't delay! I hope to see many of you in marvelous Ghent this coming March!

Science Magazine@science.org · 8mo ago

In partnership with @vibtrainconf.bsky.social, #ScienceImmunology is organizing #Type2Immunity26 in Ghent 9–10 March 2026, bringing together leaders in the field of #Type2Immunity. Check out our lineup here: vibbio.tech/3UwmTNk 🗓️15 DEC: Travel grant deadline 🗓️8 JAN: Abstract deadline

The latest issue of #Science #Immunology is out now! This week: • evaluating large language models ( #LLMs ) / #AI as potential #systems #vaccinology tools • de novo #thymus #regeneration in the #axolotl! New content every week!!!

Science Magazine@science.org · 8mo ago

The December issue of #ScienceImmunology is out! This month's cover highlights the juvenile axolotl's ability to regenerate its thymus after complete removal—possibly making it an exception among vertebrates. Learn about this research and more: https://scim.ag/4anWlqv

This week in #Science #Immunology, Lambrecht & Hammad labs (@viblifesciences.bsky.social) use #Danish Nat'l Patient & Prescription Registries + mouse models to show that maternal #allergy & neonatal #RSV infection synergize via FcR-mediated allergen uptake to drive development of early life #asthma!

Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life

Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity.

science.org

Nov issue of #Science #Immunology out now! This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites! scim.ag/4qQA6Q6

Now in #Science #Immunology: Hirahara lab reports activated #TH2 cells store LC-UFAs present in inflamed #lung within #lipid droplets. Subsequent catabolism via #microlipophagy induces ST2-hi effector & memory TH2 cell phenotypes, exacerbating #type2 #airway #inflammation! #asthma #immunometabolism

Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity

Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells.

science.org

Recently in #Science #Immunology: Kalinichenko, Huemer, @boztugk.bsky.social, & colleagues report than #sphingolipid #metabolism & protein #palmitoylation play critical roles in the killing of target cells by #cytotoxic #lymphocytes!

Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes

Protein palmitoylation and sphingolipid metabolism control lytic granule release in cytotoxic lymphocytes via membrane targeting of SNAP23.

science.org

Last week in #Science #Immunology: two papers from Bill Schief, Facundo Batista, @profshanecrotty.bsky.social, & al. provide evidence that simultaneous #immunization with multiple #bnAb #immunogens could be a viable #HIV #vaccine strategy! Xie & al. scim.ag/3W7wfQl Sutton & al. scim.ag/4ofvKQa

I'm so excited to be in stunning Stockholm for the 50th annual meeting of the #Scandinavian Society for #Immunology! swimm.se/ssi-2025/ @finnsocimm.bsky.social @swimm-immuno.bsky.social @yssi-immunology.bsky.social @ki.se

To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025! bit.ly/SciImm_free

Thanks, @natrevimmunol.nature.com, for highlighting this exciting recent paper in #Science #Immunology!

Nature Reviews Immunology@natrevimmunol.nature.com · 10mo ago

Highlight of Science Immunology paper by @thepenkpanther.bsky.social, Alexander Rudensky and colleagues @mskcancercenter.bsky.social @scripps.edu @wcm-imp.bsky.social #immunology #immunosky #neurosky

This week in #Science #Immunology! 👇

Kilian Schober@kischober.bsky.social · 10mo ago

If the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

The October issue of #Science #Immunology is out now! This week: how #TCR avidity shapes #CD8 #TCell responses to #mRNA #vaccines and the latest research on the immunology of #brain #tumors reviewed! New content added every week! scim.ag/46TGooP

David Baker & colleagues develop an #IL21 mimic (21h10) that is more stable & shows x-reactivity against both human & murine #IL21R. 21h10 promotes potent antitumor responses in mice and in human #melanoma tumor explants, expanding low-affinity CD8 #TCells & #TH1 cells & reducing #Tregs in #tumors!

Design of a potent interleukin-21 mimic for cancer immunotherapy

A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

science.org

Now in #Science #Immunology: Deshpande, Klose, & al at Charité—Universitätsmedizin Berlin report that #ILC2 resident in #PNS communicate with neurons via #IL13 to maintain #nerve structure & pain thresholds. Mice lacking ILC2 or whose neurons are Il4ra-KO exhibit #hypersensitivity & #gait defects!

Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system

ILC2-neuron cross-talk contributes to the maintenance of nerve structure and function of the peripheral nervous system.

science.org

Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!

Inhibitory immune checkpoints in cancer immunotherapy

Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

science.org

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

Nuclear polarization to the immune synapse facilitates an early transcriptional burst

Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

science.org

Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins

Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

science.org

The September issue of #Science #Immunology is out! This week: METTL1 m⁷G RNA modification of NAD+ #metabolism → #macrophage -mediated #inflammation; proenkaphalin+ #Tregs restrain skin inflamm via control of #nociception; #RNA helicase DDX55 is regulator of naïve #TCell homeostasis scim.ag/3HKC5DP