@biorxivpreprint.bsky.social Durability and diversity of human upper airway T cell memory @profshanecrotty.bsky.social www.biorxiv.org/content/10.6... @lji.org
Prof. Shane Crotty
@profshanecrotty.bsky.social
Vaccines and immune system scientist. Professor and Chief Scientific Officer (CSO), La Jolla Institute for Immunology (LJI), a non-profit research institute.
How durable is T cell memory in the human upper airway? Our new preprint directly tracks virus-specific CD8 & CD4 T cells in human nasal tissues for >18 months—using nearly 900 monthly nasal samples. www.biorxiv.org/content/10.6...
Pat put an exceptional amount of work into this project over the past several years. The B cell immunology in the paper is a real tour de force.
Pat Madden@patmadden.bsky.social · 3mo agoOur exciting new HIV vaccine paper was published in Nature today. Thanks to Shane for the amazing opportunity to lead this study!
Excited to share our new Nature paper published today: Vaccination elicits HIV broadly neutralizing antibodies in primates www.nature.com/articles/s41... A project 14 years in the making with an outstanding team at @lji.bsky.social, @scrippsresearch.bsky.social and many collaborating institutions
Vaccination elicits HIV broadly neutralizing antibodies in primates - Nature
Nature - Vaccination elicits HIV broadly neutralizing antibodies in primates
nature.com
Thanks Eric! I worked to make this review of human immune memory to vaccines comprehensive and accessible. And I made an accompanying video lecture for those desiring a different format: www.youtube.com/watch?v=8DeZ...
Review: Immunological memory to vaccines
YouTube video by Cell Press
youtube.com
Eric Topol@erictopol.bsky.social · 5mo agoThe capacity of vaccine induced immunological memory, a stellar open-access review by @profshanecrotty.bsky.social www.cell.com/immunity/ful...
My new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy! @lji.org @cp-immunity.bsky.social authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
In our latest study in @cp-immunity.bsky.social, we followed dynamics of vaccine-specific Tfh cells for 60+ weeks after immunization. authors.elsevier.com/a/1m3mV3qNrU... We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
thanks!
Waggoner Lab@labwaggoner.bsky.social · 11mo agoVaccine-specific Tfh undergo robust early expansion, sustained proliferation, months-long persistence w/o exhaustion, and functional specialization associated w/ enhanced germinal centers & humoral immunity@cp-immunity.bsky.social @profshanecrotty.bsky.social www.cell.com/immunity/ful... @lji.org
LJI is recruiting! The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies @sciimmunology.bsky.social @profshanecrotty.bsky.social SchiefLab @lji.org @scripps.edu www.science.org/doi/10.1126/...
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/... @scienceimmuno.bsky.social @lji.org
Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.
science.org
1/ David Baltimore passed away this weekend. He was one of the greatest biologists of the past 100 years. He made extraordinary contributions to immunology, cancer, molecular biology, virology, HIV, biochemistry, genetics, and genetic engineering. He won the Nobel prize in Medicine at age 37.
Rest in peace, David Baltimore. explorers.com/david-baltim... @nationalacademies.org @nobelprize.bsky.social
New Heroes: David Baltimore
Dr. David Baltimore is a Nobel Prize-winning biologist whose work has profoundly shaped modern molecular biology and immunology. His discoveries have altered our understanding of viruses and immune…
explorers.com
A germline-targeting trimer consistently induced rare bnAb-like precursors specific for the HIV Env Apex in rhesus macaques @sciimmunology.bsky.social @profshanecrotty.bsky.social War ad & Schief www.science.org/doi/10.1126/...
A good news article in Nature today following up on these papers www.nature.com/articles/d41...
mRNA vaccines for HIV trigger strong immune response in people
Results from early-stage trial show that 80% of participants who received one of two HIV vaccine candidates produced antibodies against viral proteins.
nature.com
Prof. Shane Crotty@profshanecrotty.bsky.social · last yr.After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people. * "Tier 2" neutralizing antibodies, induced consistently. www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people. * "Tier 2" neutralizing antibodies, induced consistently. www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models
An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.
science.org
Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social www.biorxiv.org/content/10.1...
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations www.biorxiv.org/content/10.1...
Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans
Seasonal influenza vaccines are most frequently delivered as intramuscular inactivated vaccines which elicit systemic responses against the immunodominant hemagglutinin (HA) head domain. An intranasal...
biorxiv.org
Our wonderful LJI colleague Alex Sette was knighted this week! In recognition of his extraordinary contributions to immunology. As one measure of Alex's impact on immunology, he has over 140,000 scientific citations, and has 964 papers that have been cited at least 10 times.
La Jolla Institute for Immunology (LJI)@lji.org · last yr.News: LJI Professor Alessandro Sette (@settelab.bsky.social) receives Order of Merit from the Italian Republic Dr. Sette knighted for outstanding research and leadership in the field of immunology bit.ly/4d17zRd #medicine #health #ImmuneSystem #science #SanDiego
News: LJI Professor Alessandro Sette (@settelab.bsky.social) receives Order of Merit from the Italian Republic Dr. Sette knighted for outstanding research and leadership in the field of immunology bit.ly/4d17zRd #medicine #health #ImmuneSystem #science #SanDiego
LJI Professor Alessandro Sette receives Order of Merit from the Italian Republic
Sette knighted for outstanding research and leadership in the field of immunology
bit.ly
One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper… @cp-immunity.bsky.social www.cell.com/immunity/ful...
Diverse priming outcomes under conditions of very rare precursor B cells
B cells that give rise to neutralizing antibody responses can be extremely rare in the naive B cell repertoire. Madden et al. show that delivery strategy and adjuvant selection affect the recruitment ...
cell.com