Epigen Lab Kyoto
@inalab.bsky.social
Inagaki lab in Kyoto Univ. Since 2026. Study how organisms inherit and express genetic info, and how they read, write, erase, or use epigentic info. Epigenome🧬 X Plants🍀. Lab website: https://inagakilab.github.io/
What if transposases are already transcription factors in disguise? Our new preprint shows that transcriptional regulatory activity is an intrinsic property of transposases, revealing a direct route for their domestication into transcription factors. www.biorxiv.org/content/10.6...
doi.org
Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41...
Excited to be able to advertise 1x postdoc and 2x technician positions to join my group in Cambridge working on an exciting ARIA funded project to help bring a plant artificial chromosome into existence! Reposts very welcome please 🙏 (1/2)
New paper by Shusei Mori!! We found a key role of protein stability in H3K9me-induced gene silencing. MS-based hunting of new genes was very powerful. This is actually the third first-authored paper😀 by our lab alumnus Shusei, now in @c-jake-harris.bsky.social lab. academic.oup.com/nar/article/...
MBD8 is required for LDL2-mediated transcriptional repression downstream of H3K9me2 in Arabidopsis
Abstract. Histone H3 lysine 9 methylation (H3K9me) is a conserved epigenetic mark for transcriptional gene repression. In Arabidopsis, H3K9 dimethylation (
academic.oup.com
Another paper we published recently by former student Dr. Arata Hoshino! onlinelibrary.wiley.com/doi/full/10.... He found very rapid histone eviction (within 5min) associated with transcription activation after heat stress. We named the regulated genes HOT-DOGs (can you guess abbreviation?).
A Temperature Increase Induces Atf1/Pcr1‐Dependent Rapid Depletion of Histones in Transcriptionally Activated Gene Bodies in Fission Yeast
In the fission yeast Schizosaccharomyces pombe, the transcription factor complex Atf1-Pcr1 is activated by phosphorylation upon heat stress to initiate a rapid cellular response. This activated compl....
onlinelibrary.wiley.com
A while ago, but we published a paper spearheaded by Dr. Satoyo Oya now in Germany. www.cell.com/plant-commun... This paper is made possible with lots of collaboration! Check out the model in Fig. 7! I hope that this work will trigger further studies on complicated epigenome regulations in plants🍀
Comparative characterization of chromatin-targeting mechanisms across seven H3K4 methyltransferases in Arabidopsis
This study presents a comparative characterization of the seven Arabidopsis H3K4 methyltransferases using epigenomic profiling and protein–protein interaction assays. Trx/Trr-type enzymes (ATX1–ATX5) ...
cell.com