Looking forward to it! See you tomorrow. Thanks, @ASBMB!

American Society for Biochemistry and Molecular Biology@asbmb.bsky.social · 2w ago

From stress signaling to epigenetic memory, tomorrow's Transcription Webinar explores how heterochromatin is formed & inherited. Hear from: 🧬 @grewalsh.bsky.social, National #Cancer Institute 🧬 Jiemin Wong, East China Normal University 📅 July 23 | 10 a.m. ET 💻 Register for free: ow.ly/n2aQ50ZrA4E

Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41...

Thank you to @unclineberger.bsky.social and @brianstrahl.bsky.social for the invitation to give a keynote at the 9th Chromatin & Epigenetics Symposium and for organizing such a stimulating meeting. I’m grateful to the many colleagues who took the time to meet and chat—really enjoyed the discussions!

Kevin Pruitt@dr-kevin-pruitt.bsky.social · 5mo ago

My student, Grace Stroman, was selected to present at the 9th Chromatin and Epigenetics Symposium. Her presentation was exceptional! Our keynote speaker @grewalsh.bsky.social was brilliant! Thanks to the organizers, @unclineberger.bsky.social, and @brianstrahl.bsky.social for a remarkable meeting!

Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar. Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse. www.biorxiv.org/content/10.6...

Heterochromatin self-propagation is actively regulated by H3K14-ub in response to external stimuli, with broad implications for rapid changes in the epigenetic landscape in physiology and disease @nature.com @grewalsh.bsky.social @ncicancer.bsky.social www.nature.com/articles/s41...

Stress controls epigenetic inheritance! A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer 👉 nature.com/articles/s41586-025-09899-8

It was wonderful to host Shiv Grewal @grewalsh.bsky.social from NIH earlier this week. Shiv gave a beautiful talk on heterochromatin propagation and the epigenetic landscape. We had a stimulating discussion after his lecture. It was also great to have him visit my single-molecule biophysics lab.

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology

Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

nature.com

Grateful for the warm welcome @tifrhyderabad.bsky.social :) Thrilled to be part of this vibrant scientific community and eager to build an exciting research program!

TIFR Hyderabad@tifrhyderabad.bsky.social · last yr.

We are delighted to welcome our newest faculty member, Sahana Holla (‪@sahanaholla.bsky.social‬). She is investigating the biological significance of 3D genome organization during development & disease, with an interdisciplinary approach combining genomics, proteomics, and advanced imaging.

So proud of you, @sahanaholla! Watching your journey has been such a joy. Wishing you all the best as you begin this exciting new chapter at TIFRH. They’re lucky to have you!

Sahana Holla@sahanaholla.bsky.social · last yr.

Thrilled to share that I’ve joined @tifrhyderabad.bsky.social as an Assistant Professor! Grateful to my mentors (esp @grewalsh.bsky.social and KN Balaji), colleagues, friends, family & EVERYONE who made this possible. Excited to explore Epigenetics & the 3D Genome with the brilliant minds in India!

Remembering Dave’s goodness gives me hope every day.

Shiv Grewal@grewalsh.bsky.social · last yr.

It was an honor to speak at the Rockefeller University symposium celebrating David Allis—a true visionary who transformed the field of chromatin and gene expression. His legacy continues to inspire us all. Grateful to the organizers for such a meaningful and inspiring event.

It was an honor to speak at the Rockefeller University symposium celebrating David Allis—a true visionary who transformed the field of chromatin and gene expression. His legacy continues to inspire us all. Grateful to the organizers for such a meaningful and inspiring event.

What was that you said? You are looking for new #RNA research to read in the weekend? You are in luck! 📣 📣 Check out the new preprint from our lab!!!! 📣 📣 www.biorxiv.org/content/10.1...

AGO2 slicing of a domesticated retrotransposon is necessary for normal vasculature development

Argonaute (AGO) mediated slicing of RNA, also known as RNAi, is a highly conserved phenomenon that is evolutionarily linked to the repression of transposons and other repeats. Although RNAi is no long...

biorxiv.org

Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres. #theconferencetoendallconferences Register now: woodstock.img.cas.cz

What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...

Our collaboration with the Muir lab revealed that N-terminal histone modifications can 'detoxify' K27M inhibition by altering PRC2-substrate interactions. Acetylation showed the greatest impact, supported by xenograft data from the Monje group. pubs.acs.org/doi/epdf/10....

We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...

Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates - Nature Structural & Molecular Biology

Here the authors show that a gene-inactivating protein complex packs inactive genes into a dynamic and accessible structure. The study challenges the traditional views that restricted accessibility an...

nature.com

🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself! 🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...

Happy New Year 2025! 🎉 As we step into another year of exploration and discovery, may curiosity guide us, innovation inspire us, and collaboration propel us forward. Here’s to breakthroughs, learning, and making the world a better place through science! 🌟 #HappyNewYear

Breaking News: Manmohan Singh, a former prime minister of India who helped transform the country’s economy, died at 92.

Manmohan Singh, Indian Premier Who Spurred Economic Boom, Dies at 92

The country’s first Sikh prime minister, he introduced free-market reforms that turned India into an economic powerhouse and sought reconciliation with Pakistan.

nytimes.com

In this episode of the Epigenetics Podcast, we talked with @maxvcg.bsky.social from the @ijmonod.bsky.social about his work on epigenetic consequences of DNA methylation in development. #podcast #chromatin #epigenetics Listen here: https://buff.ly/3ZXWGuy

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...

Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance

Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...

biorxiv.org

Thrilled to join the amazing community here on Bluesky! 🌟 Kicking off our first post with exciting news: the advanced version of our preprint is now published in Nucleic Acids Research! 🙌 [Read here: academic.oup.com/nar/advance-... Here’s a quick recap of our findings previously shared on X: 👇

A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation

Abstract. Heterochromatin plays a critical role in regulating gene expression and maintaining genome integrity. While structural and enzymatic components h

academic.oup.com

“Happy Thanksgiving! 🦃🍁 Wishing everyone a day filled with gratitude, love, and good food! Let’s take a moment to count our blessings and cherish the ones we hold dear 🧡 #Thanksgiving #Gratitude”

📢 Preprint! How does the environment of a father before conception influence offspring? Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome? We tested this systematically, with intriguing findings & some cautionary tales🧵... www.biorxiv.org/content/10.1...

Embryonic Signatures of Intergenerational Inheritance across Paternal Environments and Genetic Backgrounds

The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...

biorxiv.org

Very happy to see @grothlab.bsky.social , @helink.bsky.social and @grewalsh.bsky.social all migrating over here! All pillars of the the #epigenetics and chromatin community.